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STLK3 (human)

Overview STLK3 May act as a mediator of stress-activated signals. The phosphorylated form forms a complex with WNK2. Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; EC 2.7.11.1; STE group; STE20 family; FRAY subfamily Cellular Component: cytoskeleton; basolateral plasma membrane; apical plasma membrane; cytoplasm; nucleus Molecular Function: protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity Biological Process: positive regulation of potassium ion transport; response to stress; protein amino acid phosphorylation Reference #:  Q9UEW8 (UniProtKB) Alt. Names/Synonyms: DCHT; DKFZp686K05124; PASK; proline-alanine-rich STE20-related kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); Serine/threonine-protein kinase 39; small intestine SPAK-like kinase; SPAK; Ste-20-related kinase; Ste20-like protein kinase; STE20/SPS1-related proline-alanine-rich protein kinase; STK39 Gene Symbols: STK39 Molecular weight: 59,474 Da Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below STLK3

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	Sites Implicated In
enzymatic activity, induced: T231‑p, S309‑p, S323‑p, S371‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	9		Y63-p	WPICRDAyELQEVIG
0	4		K83-u	VVQAALCkPRQERVA
0	3		K98-u	IKRINLEkCQTSMDE
0	1		S205	ILLGEDGSVQIADFG
0	1		S214	QIADFGVSAFLAtGG
0	1		T219-p	GVSAFLAtGGDVtRN
0	1		T224-p	LAtGGDVtRNKVRKt
9	38		T231-p	tRNKVRKtFVGtPCW
1	12		T235-p	VRKtFVGtPCWMAPE
0	1		Y273-p	LATGAAPyHKyPPMK
0	1		Y276-p	GAAPyHKyPPMKVLM
0	1		Y306-p	DKEMMKKyGKsFRKL
1	0		S309-p	MMKKyGKsFRKLLSL
0	1		K312	KyGKsFRKLLSLCLQ
1	0		S323-p	LCLQKDPsKRPTAAE
0	1		K349-a	NREYLIEkLLTRtPD
0	3		K349-u	NREYLIEkLLTRtPD
0	11		T354-p	IEkLLTRtPDIAQRA
0	3		S370-p	KVRRVPGssGHLHKT
9	6		S371-p	VRRVPGssGHLHKTE
0	23		S385-p	EDGDWEWsDDEMDEK
0	1		S393	DDEMDEKSEEGKAAF
0	1		S430-p	PEQIQSLsVHDSQGP
0	16		Y444-p	PPNANEDyREAsSCA
0	1		S448-p	NEDyREAsSCAVNLV

	mouse
Y75	WPICRDAYELQEVIG
K95	VVQAALCKPRQERVA
K110	IKRINLEKCQTSMDE
S217-p	ILLGEDGsVQIADFG
S226-p	QIADFGVsAFLATGG
T231	GVsAFLATGGDVTRN
T236	LATGGDVTRNKVRKt
T243-p	TRNKVRKtFVGtPCW
T247-p	VRKtFVGtPCWMAPE
Y285	LATGAAPYHKYPPMK
Y288	GAAPYHKYPPMKVLM
Y318	DKEMMKKYGKSFRkL
S321	MMKKYGKSFRkLLSL
K324-a	KYGKSFRkLLSLCLQ
S335	LCLQKDPSKRPTAAE
K361	NREYLIEKLLTRtPD
K361-u	NREYLIEkLLTRtPD
T366-p	IEkLLTRtPDIAQRA
S382-p	KVRRVPGssGHLHKT
S383-p	VRRVPGssGHLHKTE
S397-p	EDGDWEWsDDEMDEK
S405-p	DDEMDEKsEEGKAAA
S442	PEQIQSLSVHDSQAQ
Y456	QPNANEDYREGPCAV
-	gap

	rat
Y72	WPICRDAYELQEVIG
K92-u	VVQAALCkPRQERVA
K107	IKRINLEKCQTSMDE
S214	ILLGEDGSVQIADFG
S223	QIADFGVSAFLATGG
T228	GVSAFLATGGDVTRN
T233	LATGGDVTRNKVRKt
T240-p	TRNKVRKtFVGTPCW
T244	VRKtFVGTPCWMAPE
Y282	LATGAAPYHKYPPMK
Y285	GAAPYHKYPPMKVLM
Y315	DKEMMKKYGKSFRKL
S318	MMKKYGKSFRKLLSL
K321	KYGKSFRKLLSLCLQ
S332	LCLQKDPSKRPTAAE
K358	NREYLIEKLLTRTPD
K358	NREYLIEKLLTRTPD
T363	IEKLLTRTPDIAQRA
S379	KVRRVPGSsGHLHKT
S380-p	VRRVPGSsGHLHKTE
S394	EDGDWEWSDDEMDEK
S402	DDEMDEKSEEGKAAA
S439	PEQIQSLSVHDSQGQ
Y453	QPNANEDYREGPCAV
-	gap

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