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Protein Page:
STLK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STLK3 May act as a mediator of stress-activated signals. The phosphorylated form forms a complex with WNK2. Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; FRAY subfamily
Chromosomal Location of Human Ortholog: 2q24.3
Cellular Component: cytoskeleton; basolateral plasma membrane; apical plasma membrane; cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: peptidyl-serine phosphorylation; positive regulation of potassium ion transport; regulation of inflammatory response; peptidyl-threonine phosphorylation; response to stress; protein amino acid phosphorylation
Reference #:  Q9UEW8 (UniProtKB)
Alt. Names/Synonyms: DCHT; DKFZp686K05124; PASK; proline-alanine-rich STE20-related kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); Serine/threonine-protein kinase 39; small intestine SPAK-like kinase; SPAK; Ste-20-related kinase; Ste20-like protein kinase; STE20/SPS1-related proline-alanine-rich protein kinase; STK39
Gene Symbols: STK39
Molecular weight: 59,474 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STLK3

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: T231‑p, S309‑p, S323‑p, S371‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 9 Y63-p WPICRDAyELQEVIG
0 4 K83-ub VVQAALCkPRQERVA
0 3 K98-ub IKRINLEkCQTSMDE
0 1 S205 ILLGEDGSVQIADFG
0 1 S214 QIADFGVSAFLAtGG
0 1 T219-p GVSAFLAtGGDVtRN
0 1 T224-p LAtGGDVtRNKVRKt
11 47 T231-p tRNKVRKtFVGtPCW
1 15 T235-p VRKtFVGtPCWMAPE
0 1 Y273-p LATGAAPyHKyPPMK
0 1 Y276-p GAAPyHKyPPMKVLM
0 1 Y306-p DKEMMKKyGKsFRKL
1 0 S309-p MMKKyGKsFRKLLSL
0 1 K312 KyGKsFRKLLSLCLQ
1 0 S323-p LCLQKDPsKRPTAAE
0 1 K349-ac NREYLIEkLLTRtPD
0 3 K349-ub NREYLIEkLLTRtPD
0 12 T354-p IEkLLTRtPDIAQRA
0 5 S370-p KVRRVPGssGHLHKT
13 9 S371-p VRRVPGssGHLHKTE
0 32 S385-p EDGDWEWsDDEMDEK
0 1 S393 DDEMDEKSEEGKAAF
0 1 S430-p PEQIQSLsVHDSQGP
0 15 Y444-p PPNANEDyREAsSCA
0 1 S448-p NEDyREAsSCAVNLV
  mouse

 
Y75 WPICRDAYELQEVIG
K95 VVQAALCKPRQERVA
K110 IKRINLEKCQTSMDE
S217-p ILLGEDGsVQIADFG
S226-p QIADFGVsAFLATGG
T231 GVsAFLATGGDVTRN
T236 LATGGDVTRNKVRKt
T243-p TRNKVRKtFVGtPCW
T247-p VRKtFVGtPCWMAPE
Y285 LATGAAPYHKYPPMK
Y288 GAAPYHKYPPMKVLM
Y318 DKEMMKKYGKSFRkL
S321 MMKKYGKSFRkLLSL
K324-ac KYGKSFRkLLSLCLQ
S335 LCLQKDPSKRPTAAE
K361 NREYLIEKLLTRtPD
K361-ub NREYLIEkLLTRtPD
T366-p IEkLLTRtPDIAQRA
S382-p KVRRVPGssGHLHKT
S383-p VRRVPGssGHLHKTE
S397-p EDGDWEWsDDEMDEK
S405-p DDEMDEKsEEGKAAA
S442 PEQIQSLSVHDSQAQ
Y456 QPNANEDYREGPCAV
- gap
  rat

 
Y72 WPICRDAYELQEVIG
K92-ub VVQAALCkPRQERVA
K107 IKRINLEKCQTSMDE
S214 ILLGEDGSVQIADFG
S223 QIADFGVSAFLATGG
T228 GVSAFLATGGDVTRN
T233 LATGGDVTRNKVRKt
T240-p TRNKVRKtFVGTPCW
T244 VRKtFVGTPCWMAPE
Y282 LATGAAPYHKYPPMK
Y285 GAAPYHKYPPMKVLM
Y315 DKEMMKKYGKSFRKL
S318 MMKKYGKSFRKLLSL
K321 KYGKSFRKLLSLCLQ
S332 LCLQKDPSKRPTAAE
K358 NREYLIEKLLTRtPD
K358 NREYLIEKLLTRtPD
T363-p IEKLLTRtPDIAQRA
S379 KVRRVPGSsGHLHKT
S380-p VRRVPGSsGHLHKTE
S394-p EDGDWEWsDDEMDEK
S402 DDEMDEKSEEGKAAA
S439 PEQIQSLSVHDSQGQ
Y453 QPNANEDYREGPCAV
- gap
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