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Protein Page:
MBTPS2 (human)

MBTPS2 Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop. Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Belongs to the peptidase M50A family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: Golgi membrane; cytoplasm; integral to membrane
Molecular Function: metalloendopeptidase activity; metal ion binding
Biological Process: cholesterol metabolic process; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; proteolysis
Reference #:  O43462 (UniProtKB)
Alt. Names/Synonyms: Endopeptidase S2P; FLJ32174; IFAP; MBTP2; MBTPS2; membrane-bound transcription factor peptidase, site 2; membrane-bound transcription factor protease, site 2; Membrane-bound transcription factor site-2 protease; S2P; SREBPs intramembrane protease; Sterol regulatory element-binding proteins intramembrane protease
Gene Symbols: MBTPS2
Molecular weight: 57,444 Da
Basal Isoelectric point: 7.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


0 2 S116-p SPSSYSSssSsSSSS
0 3 S117-p PSSYSSssSsSSSSS
0 2 S119-p SYSSssSsSSSSSss
0 2 S125-p SsSSSSSssSSSSSS
0 2 S126-p sSSSSSssSSSSSSS

S116-p SPSPYSSssSsSssS
S117-p PSPYSSssSsSssSS
S119-p PYSSssSsSssSSSS
S121-p SSssSsSssSSSSSS
S122-p SssSsSssSSSSSSS
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