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MBTPS2 (human)

Overview MBTPS2 Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop. Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Belongs to the peptidase M50A family. Note: This description may include information from UniProtKB. Protein type: EC 3.4.24.85; Protease; Membrane protein, integral Cellular Component: Golgi membrane; cytoplasm; integral to membrane Molecular Function: metal ion binding; metalloendopeptidase activity Biological Process: cholesterol metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; proteolysis Reference #:  O43462 (UniProtKB) Alt. Names/Synonyms: Endopeptidase S2P; FLJ32174; IFAP; MBTP2; MBTPS2; membrane-bound transcription factor peptidase, site 2; membrane-bound transcription factor protease, site 2; Membrane-bound transcription factor site-2 protease; S2P; SREBPs intramembrane protease; Sterol regulatory element-binding proteins intramembrane protease Gene Symbols: MBTPS2 Molecular weight: 57,444 Da Basal Isoelectric point: 7.21  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MBTPS2

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S111	QMMADSPSSYSSssS
0	1		S115	DSPSSYSSssSsSSS
0	2		S116-p	SPSSYSSssSsSSSS
0	3		S117-p	PSSYSSssSsSSSSS
0	2		S119-p	SYSSssSsSSSSSss
0	2		S125-p	SsSSSSSssSSSSSS
0	2		S126-p	sSSSSSssSSSSSSS
0	1		S265-p	ITEVAEDsPAIGPRG

	mouse
S111-p	QMMADSPsPYSsssS
S115-p	DSPsPYSsssSsSss
S116-p	SPsPYSsssSsSssS
S117-p	PsPYSsssSsSssSS
S119-p	PYSsssSsSssSSSS
S121-p	SsssSsSssSSSSSS
S122-p	sssSsSssSSSSSSS
S261	ITEVAEDSPAIGPRG

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