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Protein Page:
MBTPS2 (human)

MBTPS2 Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop. Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Belongs to the peptidase M50A family. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Membrane protein, multi-pass; Protease
Chromosomal Location of Human Ortholog: Xp22.12-p22.11
Cellular Component: Golgi membrane; cytoplasm; integral to membrane
Molecular Function: metalloendopeptidase activity; metal ion binding
Biological Process: cholesterol metabolic process; cellular protein metabolic process; membrane protein intracellular domain proteolysis; unfolded protein response; positive regulation of transcription factor activity
Disease: Ifap Syndrome With Or Without Bresheck Syndrome; Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-linked; Keratosis Follicularis Spinulosa Decalvans, X-linked
Reference #:  O43462 (UniProtKB)
Alt. Names/Synonyms: Endopeptidase S2P; FLJ32174; IFAP; MBTP2; MBTPS2; membrane-bound transcription factor peptidase, site 2; membrane-bound transcription factor protease, site 2; Membrane-bound transcription factor site-2 protease; S2P; SREBPs intramembrane protease; Sterol regulatory element-binding proteins intramembrane protease
Gene Symbols: MBTPS2
Molecular weight: 57,444 Da
Basal Isoelectric point: 7.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


0 1 S115 DSPSSYSSssSssSS
0 1 S116-p SPSSYSSssSssSSS
0 2 S117-p PSSYSSssSssSSSS
0 2 S119-p SYSSssSssSSSSss
0 1 S120-p YSSssSssSSSSssS
0 2 S125-p SssSSSSssSSSSSS
0 2 S126-p ssSSSSssSSSSSSS

S115-p DSPSPYSsSsSsSss
S117-p PSPYSsSsSsSssSS
S119-p PYSsSsSsSssSSSS
S121-p SsSsSsSssSSSSSS
S122-p sSsSsSssSSSSSSS
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