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RHEB (human)

Overview RHEB Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity. Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR. Interacts with TSC2. Ubiquitous. Highest levels observed in skeletal and cardiac muscle. Alternates between an inactive form bound to GDP and an active form bound to GTP. Inactivated by TSC1-TSC2 via the GTPase activating protein (GAP) domain of TSC2. Belongs to the small GTPase superfamily. Rheb family. Note: This description may include information from UniProtKB. Protein type: G protein, monomeric (Rheb) Cellular Component: spliceosome; membrane; plasma membrane; cytosol Molecular Function: GTPase activity; GTP binding; metal ion binding; protein kinase binding Biological Process: small GTPase mediated signal transduction; insulin receptor signaling pathway; cell cycle arrest; signal transduction; positive regulation of TOR signaling pathway Reference #:  Q15382 (UniProtKB) Alt. Names/Synonyms: GTP-binding protein Rheb; MGC111559; Ras homolog enriched in brain; Ras homolog enriched in brain 2; RHEB; RHEB2 Gene Symbols: RHEB Molecular weight: 20,497 Da Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling  |  mTOR Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RHEB 1XTQ - A=1-169 (human) 1XTR - A=1-169 (human) 1XTS - A=1-169 (human) 3SEA - A/B=3-169 (human) 3T5G - A=1-181 (human) 2L0X - A=6-174 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1XTQ 1XTR 1XTS 3SEA 3T5G  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	5		Y14	RKIAILGYRSVGKSS
0	2		K120-u	PIMLVGNkKDLHMER
1	0		S130-p	LHMERVIsYEEGkAL
0	1		K135-u	VIsYEEGkALAESWN
0	1		K151-u	AFLESSAkENQTAVD
0	1		R161	QTAVDVFRRIILEAE
0	1		K169	RIILEAEKMDGAAsQ
0	1		K169-u	RIILEAEkMDGAAsQ
0	5		S175-p	EkMDGAAsQGKSSCS

	mouse
Y14	RKIAILGYRSVGKSS
K120-u	PIMLVGNkKDLHMER
S130	LHMERVISYEEGKAL
K135	VISYEEGKALAESWN
K151	AFLESSAKENQTAVD
K161-u	QTAVDVFkRIILEAE
K169-a	RIILEAEkIDGAAsQ
K169	RIILEAEKIDGAAsQ
S175-p	EkIDGAAsQGKSSCS

	rat
Y14-p	RKIAILGyRSVGKSS
K120	PIMLVGNKKDLHMER
S130	LHMERVISYEEGKAL
K135	VISYEEGKALAESWN
K151	AFLESSAKENQTAVD
R161	QTAVDVFRRIILEAE
K169	RIILEAEKIDGAASQ
K169	RIILEAEKIDGAASQ
S175	EKIDGAASQGKSSCS

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