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TUBA1B (human)

Overview TUBA1B Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Belongs to the tubulin family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: microtubule cytoskeleton; microtubule; cytoplasmic microtubule Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton; structural molecule activity Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; cell division; cytoskeleton-dependent intracellular transport; microtubule cytoskeleton organization and biogenesis; microtubule-based movement; microtubule-based process Reference #:  P68363 (UniProtKB) Alt. Names/Synonyms: alpha tubulin; Alpha-tubulin ubiquitous; K-ALPHA-1; TBA1B; TUBA1B; Tubulin alpha-1B chain; Tubulin alpha-ubiquitous chain; Tubulin K-alpha-1; tubulin, alpha 1b; tubulin, alpha, ubiquitous Gene Symbols: TUBA1B Molecular weight: 50,152 Da Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TUBA1B 2E4H - B=416-451 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE 602529 602530  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	16		K40-a	DGQMPSDktIGGGDD
0	10		K40-u	DGQMPSDktIGGGDD
0	2		T41-p	GQMPSDktIGGGDDs
0	43		S48-p	tIGGGDDsFNtFFsE
0	15		T51-p	GGDDsFNtFFsETGA
0	14		S54-p	DsFNtFFsETGAGkH
0	5		K60-a	FsETGAGkHVPRAVF
0	103		K60-u	FsETGAGkHVPRAVF
0	12		T73-p	VFVDLEPtVIDEVRt
0	13		T80-p	tVIDEVRtGtYRQLF
0	102		T82-p	IDEVRtGtYRQLFHP
0	4		K96-a	PEQLITGkEDAANNy
0	142		K96-u	PEQLITGkEDAANNy
0	588		Y103-p	kEDAANNyARGHytI
0	39		Y108-p	NNyARGHytIGkEII
0	6		T109-p	NyARGHytIGkEIID
0	8		K112-a	RGHytIGkEIIDLVL
0	101		K112-u	RGHytIGkEIIDLVL
0	6		K124-a	LVLDRIRkLADQCTG
0	24		K124-u	LVLDRIRkLADQCTG
0	4		S158-p	SLLMERLsVDyGkkS
0	51		Y161-p	MERLsVDyGkkSkLE
0	29		K163-a	RLsVDyGkkSkLEFS
0	86		K163-u	RLsVDyGkkSkLEFS
0	28		K164-u	LsVDyGkkSkLEFSI
0	22		K166-u	VDyGkkSkLEFSIYP
0	29		Y185-p	STAVVEPyNSILttH
0	15		T190-p	EPyNSILttHTTLEH
0	8		T191-p	PyNSILttHTTLEHS
0	386		Y210-p	MVDNEAIyDICRRNL
0	33		T223-p	NLDIERPtytNLNRL
0	241		Y224-p	LDIERPtytNLNRLI
0	2		T225-p	DIERPtytNLNRLIs
0	27		S232-p	tNLNRLIsQIVSSIT
0	5		Y262-p	FQTNLVPyPRIHFPL
0	24		T271-p	RIHFPLAtyAPVIsA
0	460		Y272-p	IHFPLAtyAPVIsAE
0	17		S277-p	AtyAPVIsAEkAyHE
0	3		K280-a	APVIsAEkAyHEQLs
0	12		K280-u	APVIsAEkAyHEQLs
0	74		Y282-p	VIsAEkAyHEQLsVA
0	37		S287-p	kAyHEQLsVAEITNA
0	93		K304-u	EPANQMVkCDPRHGk
0	19		K311-a	kCDPRHGkyMACCLL
0	79		K311-u	kCDPRHGkyMACCLL
0	69		Y312-p	CDPRHGkyMACCLLy
0	170		Y319-p	yMACCLLyRGDVVPk
0	4		K326-a	yRGDVVPkDVNAAIA
0	119		K326-u	yRGDVVPkDVNAAIA
0	14		T334-p	DVNAAIAtIktkRsI
0	1		K336-a	NAAIAtIktkRsIQF
0	132		K336-u	NAAIAtIktkRsIQF
0	16		T337-p	AAIAtIktkRsIQFV
0	35		K338-u	AIAtIktkRsIQFVD
0	25		S340-p	AtIktkRsIQFVDWC
0	45		K352-a	DWCPTGFkVGINyQP
0	42		K352-u	DWCPTGFkVGINyQP
0	696		Y357-p	GFkVGINyQPPtVVP
0	84		T361-p	GINyQPPtVVPGGDL
0	165		K370-u	VPGGDLAkVQRAVCM
0	2		S379-p	QRAVCMLsNTTAIAE
0	10		K394-a	AWARLDHkFDLMyAk
1	0		K394-m	AWARLDHkFDLMyAk
0	121		K394-u	AWARLDHkFDLMyAk
0	421		Y399-p	DHkFDLMyAkRAFVH
0	19		K401-a	kFDLMyAkRAFVHWY
0	117		K401-u	kFDLMyAkRAFVHWY
0	191		Y432-p	MAALEKDyEEVGVDs
0	61		S439-p	yEEVGVDsVEGEGEE
0	217		Y451-p	GEEEGEEy_______

	mouse
K40-a	DGQMPSDktIGGGDD
K40-u	DGQMPSDktIGGGDD
T41-p	GQMPSDktIGGGDDs
S48-p	tIGGGDDsFNtFFsE
T51-p	GGDDsFNtFFsETGA
S54-p	DsFNtFFsETGAGkH
K60-a	FsETGAGkHVPRAVF
K60-u	FsETGAGkHVPRAVF
T73-p	VFVDLEPtVIDEVRT
T80	tVIDEVRTGtYRQLF
T82-p	IDEVRTGtYRQLFHP
K96	PEQLITGKEDAANNy
K96-u	PEQLITGkEDAANNy
Y103-p	kEDAANNyARGHYtI
Y108	NNyARGHYtIGkEII
T109-p	NyARGHYtIGkEIID
K112	RGHYtIGKEIIDLVL
K112-u	RGHYtIGkEIIDLVL
K124-a	LVLDRIRkLADQCTG
K124	LVLDRIRKLADQCTG
S158-p	SLLMERLsVDyGkkS
Y161-p	MERLsVDyGkkSkLE
K163-a	RLsVDyGkkSkLEFS
K163-u	RLsVDyGkkSkLEFS
K164-u	LsVDyGkkSkLEFSI
K166-u	VDyGkkSkLEFSIYP
Y185	STAVVEPYNSILTTH
T190	EPYNSILTTHTTLEH
T191	PYNSILTTHTTLEHS
Y210-p	MVDNEAIyDICRRNL
T223-p	NLDIERPtytNLNRL
Y224-p	LDIERPtytNLNRLI
T225-p	DIERPtytNLNRLIs
S232-p	tNLNRLIsQIVSSIT
Y262	FQTNLVPYPRIHFPL
T271	RIHFPLATyAPVIsA
Y272-p	IHFPLATyAPVIsAE
S277-p	ATyAPVIsAEkAYHE
K280	APVIsAEKAYHEQLS
K280-u	APVIsAEkAYHEQLS
Y282	VIsAEkAYHEQLSVA
S287	kAYHEQLSVAEITNA
K304-u	EPANQMVkCDPRHGk
K311	kCDPRHGKYMACCLL
K311-u	kCDPRHGkYMACCLL
Y312	CDPRHGkYMACCLLy
Y319-p	YMACCLLyRGDVVPk
K326	yRGDVVPKDVNAAIA
K326-u	yRGDVVPkDVNAAIA
T334-p	DVNAAIAtIktkRsI
K336	NAAIAtIKtkRsIQF
K336-u	NAAIAtIktkRsIQF
T337-p	AAIAtIktkRsIQFV
K338-u	AIAtIktkRsIQFVD
S340-p	AtIktkRsIQFVDWC
K352-a	DWCPTGFkVGINyQP
K352-u	DWCPTGFkVGINyQP
Y357-p	GFkVGINyQPPtVVP
T361-p	GINyQPPtVVPGGDL
K370-u	VPGGDLAkVQRAVCM
S379-p	QRAVCMLsNTTAIAE
K394	AWARLDHKFDLMyAk
K394	AWARLDHKFDLMyAk
K394-u	AWARLDHkFDLMyAk
Y399-p	DHkFDLMyAkRAFVH
K401-a	kFDLMyAkRAFVHWY
K401-u	kFDLMyAkRAFVHWY
Y432-p	MAALEKDyEEVGVDs
S439-p	yEEVGVDsVEGEGEE
Y451-p	GEEEGEEy_______

	rat
K40	DGQMPSDKTIGGGDD
K40	DGQMPSDKTIGGGDD
T41	GQMPSDKTIGGGDDS
S48	TIGGGDDSFNTFFSE
T51	GGDDSFNTFFSETGA
S54	DSFNTFFSETGAGkH
K60	FSETGAGKHVPRAVF
K60-u	FSETGAGkHVPRAVF
T73	VFVDLEPTVIDEVRT
T80	TVIDEVRTGTYRQLF
T82	IDEVRTGTYRQLFHP
K96	PEQLITGKEDAANNy
K96-u	PEQLITGkEDAANNy
Y103-p	kEDAANNyARGHYTI
Y108	NNyARGHYTIGKEII
T109	NyARGHYTIGKEIID
K112	RGHYTIGKEIIDLVL
K112	RGHYTIGKEIIDLVL
K124	LVLDRIRKLADQCTG
K124	LVLDRIRKLADQCTG
S158	SLLMERLSVDYGkkS
Y161	MERLSVDYGkkSKLE
K163-a	RLSVDYGkkSKLEFS
K163-u	RLSVDYGkkSKLEFS
K164-u	LSVDYGkkSKLEFSI
K166	VDYGkkSKLEFSIYP
Y185	STAVVEPYNSILTTH
T190	EPYNSILTTHTTLEH
T191	PYNSILTTHTTLEHS
Y210	MVDNEAIYDICRRNL
T223	NLDIERPTyTNLNRL
Y224-p	LDIERPTyTNLNRLI
T225	DIERPTyTNLNRLIs
S232-p	TNLNRLIsQIVSSIT
Y262	FQTNLVPYPRIHFPL
T271	RIHFPLATyAPVISA
Y272-p	IHFPLATyAPVISAE
S277	ATyAPVISAEKAyHE
K280	APVISAEKAyHEQLS
K280	APVISAEKAyHEQLS
Y282-p	VISAEKAyHEQLSVA
S287	KAyHEQLSVAEITNA
K304-u	EPANQMVkCDPRHGk
K311	kCDPRHGKyMACCLL
K311-u	kCDPRHGkyMACCLL
Y312-p	CDPRHGkyMACCLLy
Y319-p	yMACCLLyRGDVVPk
K326	yRGDVVPKDVNAAIA
K326-u	yRGDVVPkDVNAAIA
T334-p	DVNAAIAtIkTkRSI
K336-a	NAAIAtIkTkRSIQF
K336-u	NAAIAtIkTkRSIQF
T337	AAIAtIkTkRSIQFV
K338-u	AIAtIkTkRSIQFVD
S340	AtIkTkRSIQFVDWC
K352	DWCPTGFKVGINyQP
K352-u	DWCPTGFkVGINyQP
Y357-p	GFkVGINyQPPTVVP
T361	GINyQPPTVVPGGDL
K370-u	VPGGDLAkVQRAVCM
S379	QRAVCMLSNTTAIAE
K394-a	AWARLDHkFDLMyAk
K394	AWARLDHKFDLMyAk
K394-u	AWARLDHkFDLMyAk
Y399-p	DHkFDLMyAkRAFVH
K401-a	kFDLMyAkRAFVHWY
K401-u	kFDLMyAkRAFVHWY
Y432	MAALEKDYEEVGVDS
S439	YEEVGVDSVEGEGEE
Y451	GEEEGEEY_______

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