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Protein Page:
SGK2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SGK2 Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Highly expressed in liver, kidney and pancreas, and at lower levels in brain. Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser- 416), need to be phsphorylated for its full activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, AGC; Kinase, protein; AGC group; SGK family
Cellular Component: nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; potassium channel regulator activity; sodium channel regulator activity; ATP binding
Biological Process: positive regulation of transporter activity; response to oxidative stress; regulation of cell growth; transmembrane transport; protein amino acid phosphorylation; regulation of cell proliferation
Reference #:  Q9HBY8 (UniProtKB)
Alt. Names/Synonyms: dJ138B7.2; H-SGK2; Serine/threonine-protein kinase Sgk2; serum/glucocorticoid regulated kinase 2; Serum/glucocorticoid-regulated kinase 2; SGK2
Gene Symbols: SGK2
Molecular weight: 47,604 Da
Basal Isoelectric point: 7.16  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SGK2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T251-p GVEPEDTtStFCGTP
1 2 T253-p EPEDTtStFCGTPEY
0 1 Y285-p WCLGAVLyEMLHGLP
0 1 K331 LLQSLLHKDQRQRLG
0 1 K363 NWDDLYHKRLtPPFN
0 1 T366-p DLYHKRLtPPFNPNV
  mouse

 
T191 CVEPEETTStFCGTP
T193-p EPEETTStFCGTPEY
Y225 WCLGAVLYEMLHGLP
K271-u LLQGLLHkDQRQRLG
K303-u NWDDLYHkRLtPPFN
T306-p DLYHkRLtPPFNPNV
  rat

 
T191 CVEPEETTSTFCGTP
T193 EPEETTSTFCGTPEY
Y225 WCLGAVLYEMLHGLP
K271 LLQGLLHKDQRQRLG
K303 NWDDLYHKRLTPPFN
T306 DLYHKRLTPPFNPNV
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