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SGK2 (human)

Overview SGK2 Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Highly expressed in liver, kidney and pancreas, and at lower levels in brain. Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser- 416), need to be phsphorylated for its full activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; AGC group; SGK family Cellular Component: cytoplasm; nucleus Molecular Function: protein serine/threonine kinase activity; potassium channel regulator activity; sodium channel regulator activity; ATP binding Biological Process: positive regulation of transporter activity; protein kinase cascade; response to oxidative stress; regulation of cell growth; protein amino acid phosphorylation; regulation of cell proliferation Reference #:  Q9HBY8 (UniProtKB) Alt. Names/Synonyms: dJ138B7.2; H-SGK2; Serine/threonine-protein kinase Sgk2; serum/glucocorticoid regulated kinase 2; Serum/glucocorticoid-regulated kinase 2; SGK2 Gene Symbols: SGK2 Molecular weight: 47,604 Da Basal Isoelectric point: 7.16  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SGK2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T251-p	GVEPEDTtStFCGTP
1	2		T253-p	EPEDTtStFCGTPEY
0	1		Y285-p	WCLGAVLyEMLHGLP
0	1		K331	LLQSLLHKDQRQRLG
0	1		K363	NWDDLYHKRLtPPFN
0	1		T366-p	DLYHKRLtPPFNPNV

	mouse
T191	CVEPEETTStFCGTP
T193-p	EPEETTStFCGTPEY
Y225	WCLGAVLYEMLHGLP
K271-u	LLQGLLHkDQRQRLG
K303-u	NWDDLYHkRLtPPFN
T306-p	DLYHkRLtPPFNPNV

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