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C/EBP-epsilon (human)

Overview C/EBP-epsilon C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Belongs to the bZIP family. C/EBP subfamily. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Transcription factor; DNA binding protein Cellular Component: nucleolus; nucleus Molecular Function: protein homodimerization activity; sequence-specific DNA binding; protein heterodimerization activity; transcription factor activity Biological Process: macrophage differentiation; transcription, DNA-dependent; cytokine biosynthetic process; defense response to bacterium; defense response; phagocytosis Reference #:  Q15744 (UniProtKB) Alt. Names/Synonyms: C/EBP epsilon; C/EBP-epsilon; CCAAT/enhancer binding protein (C/EBP), epsilon; CCAAT/enhancer-binding protein epsilon; CEBPE; CRP1 Gene Symbols: CEBPE Molecular weight: 30,603 Da Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states

Select Structure to View Below C/EBP-epsilon 3T92 - A=37-61 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  DISEASE 245480 600749  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell differentiation, altered: T74‑p transcription, altered: T74‑p molecular association, regulation: T74‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
2	6		T74-p	RGLKGPGtPAFPHyL
0	1		Y80-p	GtPAFPHyLPPDPRP
0	7		Y107-p	KALGPGIyssPGSYD
0	1		S108-p	ALGPGIyssPGSYDP
0	1		S109-p	LGPGIyssPGSYDPR
2	0		K121-s	DPRAVAVkEEPRGPE
0	3		S181-p	ATAAPPCsPLLKAPs
0	1		S188-p	sPLLKAPsPAGPLHK
0	1		L193	APsPAGPLHKGKKAV
0	1		Y207-p	VNKDSLEyRLRRERN

	mouse
A74	RSLKGPGAPSFPHYL
Y80	GAPSFPHYLPADPRP
Y107-p	KALGPGIySNPGSYD
S108	ALGPGIySNPGSYDP
N109	LGPGIySNPGSYDPR
K121	DPRAVAVKEEPRGPE
S181-p	AAAAPPCsPLLKAPs
S188-p	sPLLKAPsPAGPsHK
S193-p	APsPAGPsHKGKKAV
Y207	VNKDSLEYRLRRERN

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