H3 (human)

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Protein Page:

H3 (human)

p	Phosphorylation
a	Acetylation
m	Methylation
m1	Mono-methylation
m2	Di-methylation
m3	Tri-methylation
u	Ubiquitination
s	Sumoylation
n	Neddylation
g	O-GlcNAc
h	Palmitoylation
ad	Adenylylation
sn	S-Nitrosylation
ca	Caspase cleavage

Overview

H3 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H3 family. Note: This description may include information from UniProtKB.

Protein type: DNA binding protein

Reference #: P68431 (UniProtKB)

Alt. Names/Synonyms: H3 histone family, member A; H3/A; H31; H3FA; H3FB; H3FC; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; histone 1, H3a; histone cluster 1, H3a; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.		human

1	0	R3-m	_____MArtkQtArk
4	0	R3-m2	_____MArtkQtArk
17	1	T4-p	____MArtkQtArks
5	1	K5-a	___MArtkQtArkst
19	0	K5-m	___MArtkQtArkst
36	1	K5-m1	___MArtkQtArkst
88	0	K5-m2	___MArtkQtArkst
106	0	K5-m3	___MArtkQtArkst
2	0	T7-p	_MArtkQtArkstGG
1	1	R9-m2	ArtkQtArkstGGkA
132	334	K10-a	rtkQtArkstGGkAP
17	0	K10-m	rtkQtArkstGGkAP
30	3	K10-m1	rtkQtArkstGGkAP
94	4	K10-m2	rtkQtArkstGGkAP
83	4	K10-m3	rtkQtArkstGGkAP
167	6	S11-p	tkQtArkstGGkAPr
8	1	T12-p	kQtArkstGGkAPrk
110	347	K15-a	ArkstGGkAPrkQLA
1	0	K15-m	ArkstGGkAPrkQLA
0	2	K15-m1	ArkstGGkAPrkQLA
2	2	K15-m2	ArkstGGkAPrkQLA
0	2	K15-m3	ArkstGGkAPrkQLA
0	11	K15-u	ArkstGGkAPrkQLA
5	0	R18-m	stGGkAPrkQLATkA
7	0	R18-m2	stGGkAPrkQLATkA
36	373	K19-a	tGGkAPrkQLATkAA
4	2	K19-m1	tGGkAPrkQLATkAA
0	75	K19-u	tGGkAPrkQLATkAA
23	413	K24-a	PrkQLATkAArksAP
2	13	K24-m1	PrkQLATkAArksAP
0	1	K24	PrkQLATKAArksAP
0	4	K24-m3	PrkQLATkAArksAP
0	101	K24-u	PrkQLATkAArksAP
1	0	K24-s	PrkQLATkAArksAP
1	0	R27-m	QLATkAArksAPATG
0	1	R27-m1	QLATkAArksAPATG
3	2	R27-m2	QLATkAArksAPATG
21	16	K28-a	LATkAArksAPATGG
5	2	K28-m	LATkAArksAPATGG
21	34	K28-m1	LATkAArksAPATGG
35	10	K28-m2	LATkAArksAPATGG
88	4	K28-m3	LATkAArksAPATGG
0	56	K28-u	LATkAArksAPATGG
37	5	S29-p	ATkAArksAPATGGV
8	8	K37-a	APATGGVkkPHRyRP
2	0	K37-m	APATGGVkkPHRyRP
17	33	K37-m1	APATGGVkkPHRyRP
33	8	K37-m2	APATGGVkkPHRyRP
33	4	K37-m3	APATGGVkkPHRyRP
0	51	K37-u	APATGGVkkPHRyRP
1	0	K38-a	PATGGVkkPHRyRPG
0	32	K38-m1	PATGGVkkPHRyRPG
0	3	K38-m2	PATGGVkkPHRyRPG
0	1	K38-m3	PATGGVkkPHRyRPG
0	3	K38-u	PATGGVkkPHRyRPG
0	1	R41	GGVkkPHRyRPGtVA
2	3	Y42-p	GVkkPHRyRPGtVAL
2	6	T46-p	PHRyRPGtVALREIR
0	3	Y55-p	ALREIRRyQkstELL
14	3	K57-a	REIRRyQkstELLIR
2	0	K57-m1	REIRRyQkstELLIR
1	0	K57-m2	REIRRyQkstELLIR
2	0	K57-m3	REIRRyQkstELLIR
0	125	K57-u	REIRRyQkstELLIR
1	14	S58-p	EIRRyQkstELLIRk
0	3	T59-p	IRRyQkstELLIRkL
1	0	K65	stELLIRKLPFQRLV
2	0	K65-m1	stELLIRkLPFQRLV
2	0	K65-m3	stELLIRkLPFQRLV
2	142	K80-a	REIAQDFktDLRFQs
4	0	K80-m	REIAQDFktDLRFQs
16	28	K80-m1	REIAQDFktDLRFQs
32	12	K80-m2	REIAQDFktDLRFQs
10	0	K80-m3	REIAQDFktDLRFQs
0	41	K80-u	REIAQDFktDLRFQs
1	23	T81-p	EIAQDFktDLRFQss
0	6	S87-p	ktDLRFQssAVMALQ
0	1	S88-p	tDLRFQssAVMALQE
0	2	C97	VMALQEACEAyLVGL
0	6	Y100-p	LQEACEAyLVGLFED
2	42	K116-a	NLCAIHAkRVTIMPk
0	9	K116-u	NLCAIHAkRVTIMPk
3	5	K123-a	kRVTIMPkDIQLARR
2	1	K123-m1	kRVTIMPkDIQLARR
0	2	K123-m2	kRVTIMPkDIQLARR
0	34	K123-u	kRVTIMPkDIQLARR
2	0	R129	PkDIQLARRIRGERA
1	0	R130	kDIQLARRIRGERA_