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GPX1 (human)

Overview GPX1 Protects the hemoglobin in erythrocytes from oxidative breakdown. Homotetramer. Interacts with MIEN1. Belongs to the glutathione peroxidase family. Note: This description may include information from UniProtKB. Protein type: Lipid Metabolism - arachidonic acid; EC 1.11.1.9; Other Amino Acids Metabolism - glutathione; Oxidoreductase Cellular Component: mitochondrion; cytoplasm; cytosol Molecular Function: endopeptidase inhibitor activity; glutathione peroxidase activity; SH3 domain binding Biological Process: fat cell differentiation; blood vessel endothelial cell migration; myoblast proliferation; response to toxin; skeletal muscle fiber development; negative regulation of caspase activity; thermoregulation; regulation of gene expression, epigenetic; vasodilation; endothelial cell development; regulation of mammary gland epithelial cell proliferation; response to selenium ion; glutathione metabolic process; sensory perception of sound; UV protection; response to symbiotic bacterium; hydrogen peroxide catabolic process; regulation of neuron apoptosis; response to gamma radiation; negative regulation of inflammatory response to antigenic stimulus; release of cytochrome c from mitochondria; protein amino acid oxidation; nucleobase, nucleoside and nucleotide metabolic process; myotube differentiation; skeletal muscle regeneration; angiogenesis involved in wound healing; purine base metabolic process; response to xenobiotic stimulus; positive regulation of protein kinase B signaling cascade; triacylglycerol metabolic process; response to hydroperoxide; response to hydrogen peroxide; cell redox homeostasis; heart contraction; induction of apoptosis; purine nucleotide catabolic process; interaction with symbiont; induction of apoptosis by oxidative stress; negative regulation of apoptosis Reference #:  P07203 (UniProtKB) Alt. Names/Synonyms: Cellular glutathione peroxidase; Glutathione peroxidase 1; GPx-1; GPX1; GSHPx-1; GSHPX1; MGC14399; MGC88245 Gene Symbols: GPX1 Molecular weight: 22,088 Da Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GPX1 2F8A - A/B=12-196 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		A7	_MCAARLAAAAAAAQ
0	1		A12	RLAAAAAAAQSVYAF
0	1		S31	LAGGEPVSLGSLRGK
0	31		R64	TQMNELQRRLGPRGL
0	1		R64	TQMNELQRRLGPRGL
0	13		K88-a	FGHQENAkNEEILNS
0	1		K88	FGHQENAKNEEILNS
0	1		K97	EEILNSLKyVRPGGG
1	0		Y98-p	EILNSLKyVRPGGGF
0	2		K114	PNFMLFEKCEVNGAG
0	15		G121	KCEVNGAGAHPLFAF
0	1		G121	KCEVNGAGAHPLFAF
0	1		T145	DDATALMTDPKLITW
0	3		K148	TALMTDPKLITWSPV
0	1		K148	TALMTDPKLITWSPV
0	11		L149	ALMTDPKLITWSPVC
0	2		S153	DPKLITWSPVCRNDV
0	1		K166-u	DVAWNFEkFLVGPDG
0	1		S180-p	GVPLRRYsRRFQTID
0	2		A203	LSQGPSCA_______

	mouse
S7-p	_MCAARLsAAAQsTV
S12-p	RLsAAAQsTVYAFSA
S29-p	LTGGEPVsLGSLRGK
K62-a	TEMNDLQkRLGPRGL
K62-u	TEMNDLQkRLGPRGL
K86-a	FGHQENGkNEEILNS
K86-u	FGHQENGkNEEILNS
K95-a	EEILNSLkYVRPGGG
Y96	EILNSLkYVRPGGGF
K112-a	PNFTLFEkCEVNGEk
K119-a	kCEVNGEkAHPLFTF
K119-u	kCEVNGEkAHPLFTF
T143-p	DDPTALMtDPkyIIW
K146-a	TALMtDPkyIIWsPV
K146-u	TALMtDPkyIIWsPV
Y147-p	ALMtDPkyIIWsPVC
S151-p	DPkyIIWsPVCRNDI
K164	DIAWNFEKFLVGPDG
S178	GVPVRRYSRRFRTID
S201-p	LSQQSGNs_______

	rat
S7	_MSAARLSAVAQSTV
S12	RLSAVAQSTVYAFSA
S29	LAGGEPVSLGSLRGK
K62	TEMNDLQKRLGPRGL
K62	TEMNDLQKRLGPRGL
K86	FGHQENGKNEEILNS
K86	FGHQENGKNEEILNS
K95	EEILNSLKYVRPGGG
Y96	EILNSLKYVRPGGGF
K112	PNFTLFEKCEVNGEK
K119	KCEVNGEKAHPLFTF
K119	KCEVNGEKAHPLFTF
T143-p	DDPTALMtDPKyIIW
K146	TALMtDPKyIIWSPV
K146	TALMtDPKyIIWSPV
Y147-p	ALMtDPKyIIWSPVC
S151	DPKyIIWSPVCRNDI
K164	DISWNFEKFLVGPDG
S178	GVPVRRYSRRFRTID
P201	LSKQPSNP_______

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