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Protein Page:
GPX1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GPX1 Protects the hemoglobin in erythrocytes from oxidative breakdown. Homotetramer. Interacts with MIEN1. Belongs to the glutathione peroxidase family. Note: This description may include information from UniProtKB.
Protein type: EC 1.11.1.9; Oxidoreductase; Other Amino Acids Metabolism - glutathione; Lipid Metabolism - arachidonic acid
Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; cytosol; nucleus
Molecular Function: selenium binding; glutathione binding; phospholipid-hydroperoxide glutathione peroxidase activity; glutathione peroxidase activity; SH3 domain binding
Biological Process: fat cell differentiation; response to nicotine; blood vessel endothelial cell migration; response to toxin; myoblast proliferation; skeletal muscle fiber development; thermoregulation; negative regulation of caspase activity; vasodilation; regulation of gene expression, epigenetic; response to estradiol stimulus; endothelial cell development; regulation of mammary gland epithelial cell proliferation; response to selenium ion; sensory perception of sound; glutathione metabolic process; UV protection; lipoxygenase pathway; response to symbiotic bacterium; hydrogen peroxide catabolic process; response to folic acid; regulation of neuron apoptosis; response to glucose stimulus; arachidonic acid metabolic process; response to gamma radiation; negative regulation of inflammatory response to antigenic stimulus; aging; protein amino acid oxidation; nucleobase, nucleoside and nucleotide metabolic process; skeletal muscle regeneration; angiogenesis involved in wound healing; purine base metabolic process; response to xenobiotic stimulus; positive regulation of protein kinase B signaling cascade; triacylglycerol metabolic process; response to hydrogen peroxide; response to lipid hydroperoxide; heart contraction; cell redox homeostasis; purine nucleotide catabolic process; interaction with symbiont; induction of apoptosis by oxidative stress; negative regulation of apoptosis
Reference #:  P07203 (UniProtKB)
Alt. Names/Synonyms: Cellular glutathione peroxidase; Glutathione peroxidase 1; GPx-1; GPX1; GSHPx-1; GSHPX1; MGC14399; MGC88245
Gene Symbols: GPX1
Molecular weight: 22,088 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GPX1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 A7 _MCAARLAAAAAAAQ
0 1 A12 RLAAAAAAAQSVYAF
0 1 S31 LAGGEPVSLGSLRGK
0 32 R64 TQMNELQRRLGPRGL
0 1 R64 TQMNELQRRLGPRGL
0 2 R64 TQMNELQRRLGPRGL
0 14 K88-ac FGHQENAkNEEILNS
0 1 K88 FGHQENAKNEEILNS
0 1 K88 FGHQENAKNEEILNS
0 2 K97 EEILNSLKyVRPGGG
1 0 Y98-p EILNSLKyVRPGGGF
0 2 K114 PNFMLFEKCEVNGAG
0 1 K114 PNFMLFEKCEVNGAG
0 15 G121 KCEVNGAGAHPLFAF
0 1 G121 KCEVNGAGAHPLFAF
0 1 G121 KCEVNGAGAHPLFAF
0 2 T145-p DDATALMtDPkLITW
0 4 K148-ac TALMtDPkLITWSPV
0 1 K148 TALMtDPKLITWSPV
0 11 L149 ALMtDPkLITWSPVC
0 4 S153 DPkLITWSPVCRNDV
0 1 K166 DVAWNFEKFLVGPDG
0 1 K166-ub DVAWNFEkFLVGPDG
0 1 S180-p GVPLRRYsRRFQTID
0 1 S201-p ALLSQGPsCA_____
0 3 A203 LSQGPsCA_______
  mouse

 
S7-p _MCAARLsAAAQsTV
S12-p RLsAAAQsTVYAFSA
S29-p LTGGEPVsLGSLRGK
K62-ac TEMNDLQkRLGPRGL
K62-ub TEMNDLQkRLGPRGL
K62-sc TEMNDLQkRLGPRGL
K86-ac FGHQENGkNEEILNS
K86-ub FGHQENGkNEEILNS
K86-sc FGHQENGkNEEILNS
K95-ac EEILNSLkYVRPGGG
Y96 EILNSLkYVRPGGGF
K112-ac PNFTLFEkCEVNGEk
K112-sc PNFTLFEkCEVNGEk
K119-ac kCEVNGEkAHPLFTF
K119-ub kCEVNGEkAHPLFTF
K119-sc kCEVNGEkAHPLFTF
T143-p DDPTALMtDPkyIIW
K146-ac TALMtDPkyIIWsPV
K146-ub TALMtDPkyIIWsPV
Y147-p ALMtDPkyIIWsPVC
S151-p DPkyIIWsPVCRNDI
K164-ac DIAWNFEkFLVGPDG
K164 DIAWNFEKFLVGPDG
S178 GVPVRRYSRRFRTID
G199 TLLSQQSGNs_____
S201-p LSQQSGNs_______
  rat

 
S7 _MSAARLSAVAQSTV
S12 RLSAVAQSTVYAFSA
S29 LAGGEPVSLGSLRGK
K62-ac TEMNDLQkRLGPRGL
K62 TEMNDLQKRLGPRGL
K62 TEMNDLQKRLGPRGL
K86-ac FGHQENGkNEEILNS
K86 FGHQENGKNEEILNS
K86 FGHQENGKNEEILNS
K95-ac EEILNSLkYVRPGGG
Y96 EILNSLkYVRPGGGF
K112-ac PNFTLFEkCEVNGEk
K112 PNFTLFEKCEVNGEk
K119-ac kCEVNGEkAHPLFTF
K119 kCEVNGEKAHPLFTF
K119 kCEVNGEKAHPLFTF
T143-p DDPTALMtDPkyIIW
K146-ac TALMtDPkyIIWSPV
K146 TALMtDPKyIIWSPV
Y147-p ALMtDPkyIIWSPVC
S151 DPkyIIWSPVCRNDI
K164 DISWNFEKFLVGPDG
K164 DISWNFEKFLVGPDG
S178 GVPVRRYSRRFRTID
S199 ALLSKQPSNP_____
P201 LSKQPSNP_______
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