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Protein Page:
GPX1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GPX1 Protects the hemoglobin in erythrocytes from oxidative breakdown. Homotetramer. Interacts with MIEN1. Belongs to the glutathione peroxidase family. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - arachidonic acid; EC 1.11.1.9; Other Amino Acids Metabolism - glutathione; Oxidoreductase
Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; cytosol; nucleus
Molecular Function: selenium binding; glutathione binding; phospholipid-hydroperoxide glutathione peroxidase activity; glutathione peroxidase activity; SH3 domain binding
Biological Process: fat cell differentiation; response to nicotine; blood vessel endothelial cell migration; response to toxin; myoblast proliferation; skeletal muscle fiber development; thermoregulation; negative regulation of caspase activity; regulation of gene expression, epigenetic; vasodilation; endothelial cell development; response to estradiol stimulus; regulation of mammary gland epithelial cell proliferation; response to selenium ion; sensory perception of sound; glutathione metabolic process; lipoxygenase pathway; UV protection; response to symbiotic bacterium; hydrogen peroxide catabolic process; response to folic acid; regulation of neuron apoptosis; response to glucose stimulus; response to gamma radiation; arachidonic acid metabolic process; negative regulation of inflammatory response to antigenic stimulus; aging; protein amino acid oxidation; nucleobase, nucleoside and nucleotide metabolic process; skeletal muscle regeneration; angiogenesis involved in wound healing; purine base metabolic process; positive regulation of protein kinase B signaling cascade; response to xenobiotic stimulus; triacylglycerol metabolic process; response to hydrogen peroxide; heart contraction; cell redox homeostasis; response to lipid hydroperoxide; purine nucleotide catabolic process; interaction with symbiont; induction of apoptosis by oxidative stress; negative regulation of apoptosis
Reference #:  P07203 (UniProtKB)
Alt. Names/Synonyms: Cellular glutathione peroxidase; Glutathione peroxidase 1; GPx-1; GPX1; GSHPx-1; GSHPX1; MGC14399; MGC88245
Gene Symbols: GPX1
Molecular weight: 22,088 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GPX1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 A7 _MCAARLAAAAAAAQ
0 1 S31 LAGGEPVSLGSLRGK
0 31 R64 TQMNELQRRLGPRGL
0 1 R64 TQMNELQRRLGPRGL
0 13 K88-a FGHQENAkNEEILNS
0 1 K88 FGHQENAKNEEILNS
1 0 Y98-p EILNSLKyVRPGGGF
0 2 K114 PNFMLFEKCEVNGAG
0 15 G121 KCEVNGAGAHPLFAF
0 1 G121 KCEVNGAGAHPLFAF
0 1 T145 DDATALMTDPKLITW
0 3 K148 TALMTDPKLITWSPV
0 1 K148 TALMTDPKLITWSPV
0 11 L149 ALMTDPKLITWSPVC
0 3 S153 DPKLITWSPVCRNDV
0 3 A203 LSQGPSCA_______
  mouse

 
S7-p _MCAARLsAAAQSTV
S29-p LTGGEPVsLGSLRGK
K62-a TEMNDLQkRLGPRGL
K62-u TEMNDLQkRLGPRGL
K86-a FGHQENGkNEEILNS
K86-u FGHQENGkNEEILNS
Y96 EILNSLKYVRPGGGF
K112-a PNFTLFEkCEVNGEk
K119-a kCEVNGEkAHPLFTF
K119-u kCEVNGEkAHPLFTF
T143-p DDPTALMtDPkyIIW
K146-a TALMtDPkyIIWsPV
K146-u TALMtDPkyIIWsPV
Y147-p ALMtDPkyIIWsPVC
S151-p DPkyIIWsPVCRNDI
S201-p LSQQSGNs_______
  rat

 
S7 _MSAARLSAVAQSTV
S29 LAGGEPVSLGSLRGK
K62 TEMNDLQKRLGPRGL
K62 TEMNDLQKRLGPRGL
K86 FGHQENGKNEEILNS
K86 FGHQENGKNEEILNS
Y96 EILNSLKYVRPGGGF
K112 PNFTLFEKCEVNGEK
K119 KCEVNGEKAHPLFTF
K119 KCEVNGEKAHPLFTF
T143-p DDPTALMtDPKyIIW
K146 TALMtDPKyIIWSPV
K146 TALMtDPKyIIWSPV
Y147-p ALMtDPKyIIWSPVC
S151 DPKyIIWSPVCRNDI
P201 LSKQPSNP_______
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