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PSENEN (human)

Overview PSENEN Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Belongs to the PEN-2 family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; integral to plasma membrane; plasma membrane Molecular Function: protein binding Biological Process: positive regulation of catalytic activity; Notch signaling pathway; amyloid precursor protein catabolic process; membrane protein intracellular domain proteolysis; nerve growth factor receptor signaling pathway; apoptosis; membrane protein ectodomain proteolysis; Notch receptor processing; protein processing Reference #:  Q9NZ42 (UniProtKB) Alt. Names/Synonyms: Gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; MDS033; MSTP064; PEN-2; PEN2; presenilin enhancer 2 homolog (C. elegans); Presenilin enhancer protein 2; PSENEN Gene Symbols: PSENEN Molecular weight: 12,029 Da Basal Isoelectric point: 9.25  Predict pI for various phosphorylation states CST Pathways:  Alzheimer's Disease  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Notch Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PSENEN

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	5		K11-u	ERVSNEEkLNLCRKY

	mouse
K11	ERVSNEEKLNLCRKY

	rat
K11	ERVSNEEKLNLCRKY

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