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Protein Page:
CDH5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDH5 Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1. Endothelial tissues and brain. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: tight junction; membrane; integral to membrane; plasma membrane; intercellular junction; cell junction
Molecular Function: protein binding; beta-catenin binding; calcium ion binding; protein phosphatase binding; receptor binding
Biological Process: negative regulation of cell proliferation; intercellular junction assembly and maintenance; homophilic cell adhesion; blood vessel maturation
Reference #:  P33151 (UniProtKB)
Alt. Names/Synonyms: 7B4; 7B4 antigen; CADH5; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); Cadherin-5; CD144; cd144 antigen; CDH5; endothelial-specific cadherin; FLJ17376; Vascular endothelial cadherin; VE-cadherin
Gene Symbols: CDH5
Molecular weight: 87,528 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDH5

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: Y658‑p
cell motility, altered: Y658‑p
signaling pathway regulation: Y658‑p
intracellular localization: S665‑p
molecular association, regulation: Y658‑p, Y685‑p, Y731‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y82-p VSRKNAKyLLKGEYV
0 1 T212-p SGRIITItKSLDREK
0 1 Y223-p DREKQARyEIVVEAR
0 1 Y295 PQNRMTKYSILRGDY
0 1 S296 QNRMTKYSILRGDYQ
0 1 T392-p QKKPLIGtVLAMDPD
1 0 Y645 IHEQLVTYDEEGGGE
5 0 Y658-p GEMDTTSyDVSVLNs
2 0 S665-p yDVSVLNsVRRGGAK
0 4 S683-p PALDARPsLyAQVQK
6 146 Y685-p LDARPsLyAQVQKPP
0 1 K690 sLyAQVQKPPRHAPG
0 2 Y725-p HDGDGPPyDTLHIyG
5 1 Y731-p PyDTLHIyGyEGSES
1 1 Y733-p DTLHIyGyEGSESIA
0 1 Y774-p FKMLAELyGSDPREE
1 0 S776 MLAELyGSDPREELL
0 1 Y784-p DPREELLy_______
  mouse

 
Y80 VNRQNAKYVLQGEFA
I210 SGLIFTKIKNLDREK
Y221 DREKQAEYKIVVETQ
Y293-p PQNRMTKysIMQGEY
S294-p QNRMTKysIMQGEYR
T391 QKKPLIGTVVAKDPD
Y645-p IHEQLVTyDEEGGGE
Y658-p GEMDTTSyDVSVLNS
S665 yDVSVLNSVRGGSTK
A683 STMDARPAVyTQVQk
Y685-p MDARPAVyTQVQkPP
K690-ub AVyTQVQkPPRLAPG
Y725 NDGGGPPYDTLHIyG
Y731-p PYDTLHIyGyEGAES
Y733-p DTLHIyGyEGAESIA
Y774 FKMLAELYGsDPQEE
S776-p MLAELYGsDPQEELI
I784 DPQEELII_______
  rat

 
Y72 VNRQNAKYVLQGEQA
D202 SGLIFTKDKNLDRET
Y213 DRETRAEYKIVVEAQ
Y285 PQNRMTKYSIMQGEY
S286 QNRMTKYSIMQGEYR
T383 KKKPLIGTVVAKDPD
Y637 IHEQLVTYDEEGGGE
Y650 GEMDTTSYDVSVLNS
S657 YDVSVLNSVRTGSNK
A675 STMDARPAVyTQVQK
Y677-p MDARPAVyTQVQKPP
K682 AVyTQVQKPPRLAPS
Y717 NDGGGPPYDTLHIYG
Y723 PYDTLHIYGYEGTES
Y725 DTLHIYGYEGTESIA
Y766 FKMLAELYGSDPQEE
S768 MLAELYGSDPQEELI
I776 DPQEELII_______
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