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RIPK3 (human)

Overview RIPK3 Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; TKL group; RIPK family Cellular Component: mitochondrion; plasma membrane; cytosol Molecular Function: NF-kappaB-inducing kinase activity; identical protein binding; protein serine/threonine kinase activity; protein binding; transcription coactivator activity; ATP binding; protein kinase activity Biological Process: I-kappaB kinase/NF-kappaB cascade; protein heterooligomerization; induction of apoptosis; activation of protein kinase activity; positive regulation of interferon type I production; innate immune response; protein modification process; signal transduction; protein homooligomerization; activation of NF-kappaB transcription factor Reference #:  Q9Y572 (UniProtKB) Alt. Names/Synonyms: receptor interacting protein 3; Receptor-interacting protein 3; receptor-interacting serine-threonine kinase 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; RIP3; RIPK3 Gene Symbols: RIPK3 Molecular weight: 56,887 Da Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  SAPK/JNK Signaling Cascades  |  Signaling Pathways Activating p38 MAPK Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RIPK3

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		P179	SGTGSGEPGGTLGYL
1	0		S227-p	VELPTEPsLVYEAVC
0	14		S316-p	RSSNRRFsIPEsGQG
0	1		S320-p	RRFsIPEsGQGGtEM
0	1		G321	RFsIPEsGQGGtEMD
0	2		T325-p	PEsGQGGtEMDGFRR
0	2		S339-p	RTIENQHsRNDVMVS
0	1		S359-p	LNLEEPPsSVPKKCP
0	1		S372-p	CPSLTKRsRAQEEQV
0	2		W383	EEQVPQAWTAGTSSD
0	1		T398-p	SMAQPPQtPETSTFR
0	2		S410-p	TFRNQMPsPtSTGTP
1	1		-	gap
0	1		T412-p	RNQMPsPtSTGTPSP
0	3		R508	KDPEAWSRPQGWYNH
0	1		R508	KDPEAWSRPQGWYNH
0	1		Q510	PEAWSRPQGWYNHSG
0	1		Q510	PEAWSRPQGWYNHSG

	mouse
S184-p	SGSGSRDsGGTLAYL
S232-p	AELVDKTsLIRETVC
S321	RSSGRNLSAREPsQR
P325	RNLSAREPsQRGTEM
S326-p	NLSAREPsQRGTEMD
T330	REPsQRGTEMDCPRE
-	gap
G354	LHLEEPSGPVPGKCP
-	gap
T374-p	DTSVGPAtPARTSSD
I389	PVAGTPQIPHTLPFR
-	gap
T399-p	TLPFRGTtPGPVFTE
-	gap
R477-m1	YDQAQFGrGrGWQPF
R477-m2	YDQAQFGrGrGWQPF
R479	QAQFGrGRGWQPFHK
R479-m2	QAQFGrGrGWQPFHK

	rat
S182	SGSGSRDSGGTLAYL
S229	AEVVDKTSLIRGAVC
S318	RSSDTKLSARESSQK
S322	TKLSARESSQKGTEV
S323	KLSARESSQKGTEVD
T327	RESSQKGTEVDCPRE
-	gap
G351	LHLEEPSGSVPERLT
-	gap
T374	EASFGHATPAGTSSD
I389	TLAGTPQIPHTLPSR
-	gap
T399	TLPSRGTTPRPAFTE
-	gap
R474-m1	KEPAQFGrGrGW___
R474	KEPAQFGRGrGW___
R476-m1	PAQFGrGrGW_____
R476	PAQFGrGRGW_____

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