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Protein Page:
RIPK3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RIPK3 Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, TKL; TKL group; RIPK family
Cellular Component: mitochondrion; plasma membrane; cytosol
Molecular Function: NF-kappaB-inducing kinase activity; protein serine/threonine kinase activity; identical protein binding; protein binding; transcription coactivator activity; protein complex binding; ATP binding; protein kinase activity
Biological Process: spleen development; regulation of activated T cell proliferation; I-kappaB kinase/NF-kappaB cascade; thymus development; protein heterooligomerization; MyD88-independent toll-like receptor signaling pathway; protein amino acid autophosphorylation; T cell differentiation in the thymus; protein modification process; toll-like receptor 3 signaling pathway; signal transduction; lymph node development; activation of NF-kappaB transcription factor; regulation of T cell mediated cytotoxicity; regulation of adaptive immune response; regulation of interferon-gamma production; positive regulation of interferon type I production; activation of protein kinase activity; toll-like receptor signaling pathway; innate immune response; T cell homeostasis; toll-like receptor 4 signaling pathway; protein homooligomerization
Reference #:  Q9Y572 (UniProtKB)
Alt. Names/Synonyms: receptor interacting protein 3; Receptor-interacting protein 3; receptor-interacting serine-threonine kinase 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; RIP3; RIPK3
Gene Symbols: RIPK3
Molecular weight: 56,887 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RIPK3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S2 ______MSCVKLWPS
1 0 S164 KLADFGLSTFQGGSQ
0 3 P179 SGTGSGEPGGTLGYL
1 0 - gap
2 0 S227-p VELPTEPsLVYEAVC
1 0 T252-p LPQAGPEtPGLEGLK
1 0 S299 NNMNAAVSTVKDFLS
0 14 S316-p RSSNRRFsIPESGQG
1 1 G321 RFsIPESGQGGtEMD
0 2 T325-p PESGQGGtEMDGFRR
0 2 S339-p RTIENQHsRNDVMVS
1 0 V343 NQHsRNDVMVSEWLN
1 0 P358 KLNLEEPPSSVPKKC
1 0 - gap
0 2 W383 EEQVPQAWTAGTSSD
1 0 S389 AWTAGTSSDSMAQPP
1 0 T401 QPPQTPETSTFRNQM
0 2 S410-p TFRNQMPsPTSTGTP
1 1 - gap
0 4 R508 KDPEAWSRPQGWYNH
  mouse

 
S2-p ______MsSVKLWPT
S165-p KLADFGLsTFQGGSQ
S184-p SGSGSRDsGGTLAYL
T231-p EAELVDKtsLIRETV
S232-p AELVDKtsLIRETVC
T257-p LPPGSPEtPGLEKLK
S304-p DKVDAAVsEVKHYLS
S321 RSSGRNLSAREPsQR
S326-p NLSAREPsQRGTEMD
T330 REPsQRGTEMDCPRE
- gap
T338-p EMDCPREtMVSKMLD
S353-p RLHLEEPsGPVPGKC
S369-p ERQAQDTsVGPAtPA
T374-p DTsVGPAtPARTSsD
S380-p AtPARTSsDPVAGTP
T392-p GTPQIPHtLPFRGTt
- gap
T399-p tLPFRGTtPGPVFTE
R477-m1 YDQAQFGrGRGWQPF
  rat

 
S2 ______MSSVKLWLN
S165 KLADFGLSTFQGGSQ
S182 SGSGSRDSGGTLAYL
T228 EAEVVDKTSLIRGAV
S229 AEVVDKTSLIRGAVC
T254 LPPDSPETPGLEGLK
S301 DKVDAAVSKVKHYLS
S318 RSSDTKLSARESSQK
S323 KLSARESSQKGTEVD
T327 RESSQKGTEVDCPRE
- gap
T335 EVDCPRETIVYEMLD
S350 RLHLEEPSGSVPERL
S369 ERRGKEASFGHATPA
T374 EASFGHATPAGTSSD
S380 ATPAGTSSDTLAGTP
T392 GTPQIPHTLPSRGTT
- gap
T399 TLPSRGTTPRPAFTE
R474-m1 KEPAQFGrGRGW___
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