Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TKL; EC 188.8.131.52; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; RIPK family
Molecular Function: NF-kappaB-inducing kinase activity; identical protein binding; protein serine/threonine kinase activity; protein binding; transcription coactivator activity; ATP binding; protein kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; protein heterooligomerization; MyD88-independent toll-like receptor signaling pathway; protein modification process; toll-like receptor 3 signaling pathway; signal transduction; activation of NF-kappaB transcription factor; positive regulation of interferon type I production; toll-like receptor signaling pathway; activation of protein kinase activity; innate immune response; toll-like receptor 4 signaling pathway; protein homooligomerization
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.