Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
RIPK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RIPK3 Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TKL; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); TKL group; RIPK family
Cellular Component: mitochondrion; plasma membrane; cytosol
Molecular Function: NF-kappaB-inducing kinase activity; protein serine/threonine kinase activity; identical protein binding; protein binding; transcription coactivator activity; protein complex binding; ATP binding; protein kinase activity
Biological Process: spleen development; regulation of activated T cell proliferation; I-kappaB kinase/NF-kappaB cascade; thymus development; protein heterooligomerization; protein amino acid autophosphorylation; MyD88-independent toll-like receptor signaling pathway; T cell differentiation in the thymus; protein modification process; toll-like receptor 3 signaling pathway; signal transduction; lymph node development; activation of NF-kappaB transcription factor; regulation of T cell mediated cytotoxicity; regulation of adaptive immune response; regulation of interferon-gamma production; positive regulation of interferon type I production; toll-like receptor signaling pathway; activation of protein kinase activity; innate immune response; T cell homeostasis; toll-like receptor 4 signaling pathway; protein homooligomerization
Reference #:  Q9Y572 (UniProtKB)
Alt. Names/Synonyms: receptor interacting protein 3; Receptor-interacting protein 3; receptor-interacting serine-threonine kinase 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; RIP3; RIPK3
Gene Symbols: RIPK3
Molecular weight: 56,887 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RIPK3

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S2 ______MSCVKLWPS
1 0 S164 KLADFGLSTFQGGSQ
0 3 P179 SGTGSGEPGGTLGYL
1 0 - gap
2 0 S227-p VELPTEPsLVYEAVC
1 0 T252-p LPQAGPEtPGLEGLK
1 1 S299-p NNMNAAVstVKDFLS
0 1 T300-p NMNAAVstVKDFLSQ
0 15 S316-p RSSNRRFsIPEsGQG
0 1 S320-p RRFsIPEsGQGGtEM
1 1 G321 RFsIPEsGQGGtEMD
0 2 T325-p PEsGQGGtEMDGFRR
0 2 S339-p RTIENQHsRNDVMVS
1 0 V343 NQHsRNDVMVSEWLN
1 0 P358 KLNLEEPPsSVPKKC
0 1 S359-p LNLEEPPsSVPKKCP
1 0 - gap
0 1 S372-p CPSLTKRsRAQEEQV
0 2 W383 EEQVPQAWTAGTSSD
1 1 S389 AWTAGTSSDSMAQPP
1 0 T401 QPPQTPETSTFRNQM
0 2 S410-p TFRNQMPsPtSTGTP
1 1 - gap
0 1 T412-p RNQMPsPtSTGTPSP
0 4 R508 KDPEAWSRPQGWYNH
0 1 R508 KDPEAWSRPQGWYNH
0 1 Q510 PEAWSRPQGWYNHSG
0 1 Q510 PEAWSRPQGWYNHSG
  mouse

 
S2-p ______MsSVKLWPT
S165-p KLADFGLsTFQGGSQ
S184-p SGSGSRDsGGTLAYL
T231-p EAELVDKtsLIRETV
S232-p AELVDKtsLIRETVC
T257-p LPPGSPEtPGLEKLK
S304-p DKVDAAVsEVKHYLS
E305 KVDAAVsEVKHYLSQ
S321 RSSGRNLSAREPsQR
P325 RNLSAREPsQRGTEM
S326-p NLSAREPsQRGTEMD
T330 REPsQRGTEMDCPRE
- gap
T338-p EMDCPREtMVSKMLD
S353-p RLHLEEPsGPVPGKC
G354 LHLEEPsGPVPGKCP
S369-p ERQAQDTsVGPAtPA
- gap
T374-p DTsVGPAtPARTSsD
S380-p AtPARTSsDPVAGTP
T392-p GTPQIPHtLPFRGTt
- gap
T399-p tLPFRGTtPGPVFTE
- gap
R477-m1 YDQAQFGrGrGWQPF
R477-m2 YDQAQFGrGrGWQPF
R479 QAQFGrGRGWQPFHK
R479-m2 QAQFGrGrGWQPFHK
  rat

 
S2 ______MSSVKLWLN
S165 KLADFGLSTFQGGSQ
S182 SGSGSRDSGGTLAYL
T228 EAEVVDKTSLIRGAV
S229 AEVVDKTSLIRGAVC
T254 LPPDSPETPGLEGLK
S301 DKVDAAVSKVKHYLS
K302 KVDAAVSKVKHYLSQ
S318 RSSDTKLSARESSQK
S322 TKLSARESSQKGTEV
S323 KLSARESSQKGTEVD
T327 RESSQKGTEVDCPRE
- gap
T335 EVDCPRETIVYEMLD
S350 RLHLEEPSGSVPERL
G351 LHLEEPSGSVPERLT
S369 ERRGKEASFGHATPA
- gap
T374 EASFGHATPAGTSSD
S380 ATPAGTSSDTLAGTP
T392 GTPQIPHTLPSRGTT
- gap
T399 TLPSRGTTPRPAFTE
- gap
R474-m1 KEPAQFGrGrGW___
R474 KEPAQFGRGrGW___
R476-m1 PAQFGrGrGW_____
R476 PAQFGrGRGW_____
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.