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RIPK2 (human)

Overview RIPK2 a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, TKL; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); EC 2.7.10.2; TKL group; RIPK family Cellular Component: cytoplasm; cytosol Molecular Function: protein serine/threonine kinase activity; LIM domain binding; signal transducer activity; protein binding; protein homodimerization activity; CARD domain binding; non-membrane spanning protein tyrosine kinase activity; ATP binding Biological Process: I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; positive regulation of T-helper 1 type immune response; positive regulation of apoptosis; apoptosis; activation of MAPK activity; stress-activated MAPK cascade; positive regulation of JNK cascade; toll-like receptor 3 signaling pathway; signal transduction; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; T cell proliferation; response to exogenous dsRNA; positive regulation of immature T cell proliferation; lipopolysaccharide-mediated signaling pathway; JNK cascade; inflammatory response; toll-like receptor 4 signaling pathway; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; Toll signaling pathway; positive regulation of chemokine production; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-gamma production; defense response to Gram-positive bacterium; positive regulation of protein ubiquitination; toll-like receptor signaling pathway; positive regulation of interleukin-2 production; innate immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of T-helper 1 cell differentiation; positive regulation of cytokine and chemokine mediated signaling pathway Reference #:  O43353 (UniProtKB) Alt. Names/Synonyms: CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD3; CARDIAK; CCK; GIG30; growth-inhibiting gene 30; receptor interacting protein 2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; Receptor-interacting protein 2; receptor-interacting serine-threonine kinase 2; Receptor-interacting serine/threonine-protein kinase 2; RICK; RIP-2; RIP-like-interacting CLARP kinase; RIP2; RIPK2 Gene Symbols: RIPK2 Molecular weight: 61,195 Da Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  SAPK/JNK Signaling Cascades  |  Signaling Pathways Activating p38 MAPK Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RIPK2

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	Sites Implicated In
enzymatic activity, induced: S176‑p, Y474‑p molecular association, regulation: Y474‑p protein degradation: Y474‑p ubiquitination: Y474‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K17-u	LPTIPYHkLADLRYL
0	2		S168-p	KIADFGLsKWRMMsL
0	2		S174-p	LsKWRMMsLsQsRSs
1	28		S176-p	KWRMMsLsQsRSskS
0	9		S178-p	RMMsLsQsRSskSAP
0	1		S180	MsLsQsRSskSAPEG
0	2		S181-p	sLsQsRSskSAPEGG
0	2		K182-u	LsQsRSskSAPEGGT
0	2		K203-u	ENYEPGQkSRASIkH
1	0		K209-u	QkSRASIkHDIYSYA
0	1		S345-p	NHGPQEEsCGSSQLH
0	1		S357-p	QLHENSGsPETSRsL
0	2		S363-p	GsPETSRsLPAPQDN
0	344		Y381-p	SRKAQDCyFMKLHHC
0	2		S393-p	HHCPGNHsWDSTISG
0	1		S399	HsWDSTISGSQRAAF
0	11		T412	AFCDHKTTPCSSAII
0	3		P413	FCDHKTTPCSSAIIN
0	3		S415	DHKTTPCSSAIINPL
1	1		Y474-p	DLIMKEDyELVSTKP
0	8		S527-p	YPEILVVsRsPsLNL
0	6		S529-p	EILVVsRsPsLNLLQ
0	22		S531-p	LVVsRsPsLNLLQNK
0	3		S539-p	LNLLQNKsM______

	mouse
K17	LPPIPYHKLADLHYL
S168	KIADFGLSKWRMMSL
S174	LSKWRMMSLsQsRsy
S176-p	KWRMMSLsQsRsyKS
S178-p	RMMSLsQsRsyKSAP
S180-p	MSLsQsRsyKSAPEG
Y181-p	SLsQsRsyKSAPEGG
K182	LsQsRsyKSAPEGGT
K203-u	ENYEPGQkSRASVKH
K209	QkSRASVKHDIYSYA
S344	NHPPQEESCGSSLLS
S356	LLSRNTGSPGPSRSL
S362	GSPGPSRSLSAPQDK
S380	SGAPQDCSSLKAHHC
S392-p	HHCPGNHsWDGIVsV
S398-p	HsWDGIVsVPPGAAF
S411-p	AFCDRRAssCsLAVI
S412-p	FCDRRAssCsLAVIS
S414-p	DRRAssCsLAVISPF
Y473	DLIMKEDYELISTKP
S526	YPEVPVLSKAPPSNF
A528	EVPVLSKAPPSNFPQ
P530	PVLSKAPPSNFPQNK
S538-p	SNFPQNKsL______

	rat
K17	LPHIPYHKLADLHYL
S168	KIADFGLSKWRMMSL
S174	LSKWRMMSLSQSRSY
S176	KWRMMSLSQSRSYKS
S178	RMMSLSQSRSYKSAP
S180	MSLSQSRSYKSAPEG
Y181	SLSQSRSYKSAPEGG
K182	LSQSRSYKSAPEGGT
K203	ENYEPGQKSRASVKH
K209	QKSRASVKHDIYSYA
S344	SHPPQEESCGSSLLS
S356	LLSRNAGSPGTSRSL
S362	GSPGTSRSLSAPQDK
S380	HGGPQDCSSSKAYHC
S392	YHCPGNHSWDGIISV
S398	HSWDGIISVSQEAAF
S411-p	AFCDRRAssCsLTVI
S412-p	FCDRRAssCsLTVIR
S414-p	DRRAssCsLTVIRPL
Y473	DLIMKEDYELISTKP
S526	YPEVLLVSRTPSSNV
T528	EVLLVSRTPSSNVLQ
S530	LLVSRTPSSNVLQNK
T538	SNVLQNKTL______

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