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Protein Page:
RIPK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RIPK2 a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.10.2; EC 2.7.11.1; TKL group; RIPK family
Cellular Component: cytoskeleton; protein complex; cytoplasm; cytosol; vesicle
Molecular Function: protein serine/threonine kinase activity; protein binding; LIM domain binding; signal transducer activity; protein homodimerization activity; non-membrane spanning protein tyrosine kinase activity; CARD domain binding; ATP binding
Biological Process: I-kappaB kinase/NF-kappaB cascade; peptidyl-tyrosine phosphorylation; positive regulation of T-helper 1 type immune response; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; activation of MAPK activity; apoptosis; positive regulation of interleukin-12 production; stress-activated MAPK cascade; positive regulation of JNK cascade; toll-like receptor 3 signaling pathway; signal transduction; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; T cell proliferation; toll-like receptor 5 signaling pathway; response to exogenous dsRNA; positive regulation of immature T cell proliferation; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon-beta production; JNK cascade; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of interferon-alpha production; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of peptidyl-serine phosphorylation; positive regulation of chemokine production; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of interferon-gamma production; positive regulation of protein ubiquitination; positive regulation of interleukin-2 production; toll-like receptor signaling pathway; innate immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of T-helper 1 cell differentiation; positive regulation of cytokine and chemokine mediated signaling pathway; negative regulation of apoptosis
Reference #:  O43353 (UniProtKB)
Alt. Names/Synonyms: CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD3; CARDIAK; CCK; GIG30; growth-inhibiting gene 30; receptor interacting protein 2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; Receptor-interacting protein 2; receptor-interacting serine-threonine kinase 2; Receptor-interacting serine/threonine-protein kinase 2; RICK; RIP-2; RIP-like-interacting CLARP kinase; RIP2; RIPK2
Gene Symbols: RIPK2
Molecular weight: 61,195 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RIPK2

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S176‑p, Y474‑p
molecular association, regulation: Y474‑p
protein degradation: Y474‑p
ubiquitination: Y474‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K17-ub LPTIPYHkLADLRYL
0 4 S168-p KIADFGLsKWRMMsL
0 3 S174-p LsKWRMMsLsQsRSs
2 32 S176-p KWRMMsLsQsRSskS
0 12 S178-p RMMsLsQsRSskSAP
0 1 S180 MsLsQsRSskSAPEG
0 2 S181-p sLsQsRSskSAPEGG
0 2 K182-ub LsQsRSskSAPEGGT
0 2 K203-ub ENYEPGQkSRASIkH
2 0 K209-ub QkSRASIkHDIYSYA
0 1 S345-p NHGPQEEsCGSSQLH
0 1 S357-p QLHENSGsPETSRsL
0 1 S361 NSGsPETSRsLPAPQ
0 5 S363-p GsPETSRsLPAPQDN
0 1 P365 PETSRsLPAPQDNDF
0 352 Y381-p SRKAQDCyFMKLHHC
0 3 S393-p HHCPGNHsWDSTISG
0 1 S399 HsWDSTISGSQRAAF
0 11 T412 AFCDHKTTPCSSAII
0 5 P413 FCDHKTTPCSSAIIN
0 4 S415 DHKTTPCSSAIINPL
3 1 Y474-p DLIMKEDyELVSTKP
0 10 S527-p YPEILVVsRsPsLNL
0 7 S529-p EILVVsRsPsLNLLQ
0 24 S531-p LVVsRsPsLNLLQNK
0 5 S539-p LNLLQNKsM______
4364 : Phospho-RIP2 (Ser176) Antibody
  mouse

 
K17 LPPIPYHKLADLHYL
S168 KIADFGLSKWRMMSL
S174 LSKWRMMSLsQsRsy
S176-p KWRMMSLsQsRsyKS
S178-p RMMSLsQsRsyKSAP
S180-p MSLsQsRsyKSAPEG
Y181-p SLsQsRsyKSAPEGG
K182 LsQsRsyKSAPEGGT
K203-ub ENYEPGQkSRASVkH
K209-ub QkSRASVkHDIYSYA
S344 NHPPQEESCGSSLLS
S356 LLSRNTGSPGPsRSL
S360-p NTGSPGPsRSLsAPQ
S362 GSPGPsRSLsAPQDK
S364-p PGPsRSLsAPQDKGF
S380 SGAPQDCSSLKAHHC
S392-p HHCPGNHsWDGIVsV
S398-p HsWDGIVsVPPGAAF
S411-p AFCDRRAssCsLAVI
S412-p FCDRRAssCsLAVIS
S414-p DRRAssCsLAVISPF
Y473 DLIMKEDYELISTKP
S526 YPEVPVLSKAPPSNF
A528 EVPVLSKAPPSNFPQ
P530 PVLSKAPPSNFPQNK
S538-p SNFPQNKsL______
4364 : Phospho-RIP2 (Ser176) Antibody
  rat

 
K17 LPHIPYHKLADLHYL
S168 KIADFGLSKWRMMSL
S174 LSKWRMMSLSQSRSY
S176 KWRMMSLSQSRSYKS
S178 RMMSLSQSRSYKSAP
S180 MSLSQSRSYKSAPEG
Y181 SLSQSRSYKSAPEGG
K182 LSQSRSYKSAPEGGT
K203 ENYEPGQKSRASVKH
K209 QKSRASVKHDIYSYA
S344 SHPPQEESCGSSLLS
S356 LLSRNAGSPGTSRSL
S360 NAGSPGTSRSLSAPQ
S362 GSPGTSRSLSAPQDK
S364 PGTSRSLSAPQDKGF
S380 HGGPQDCSSSKAYHC
S392 YHCPGNHSWDGIISV
S398 HSWDGIISVSQEAAF
S411-p AFCDRRAssCsLTVI
S412-p FCDRRAssCsLTVIR
S414-p DRRAssCsLTVIRPL
Y473 DLIMKEDYELISTKP
S526 YPEVLLVSRTPSSNV
T528 EVLLVSRTPSSNVLQ
S530 LLVSRTPSSNVLQNK
T538 SNVLQNKTL______
4364 : Phospho-RIP2 (Ser176) Antibody
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