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Protein Page:
DNCH1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DNCH1 Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Defects in DYNC1H1 are the cause of Charcot-Marie-Tooth disease type 2O (CMT2O). CMT2O is anaxonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Defects in DYNC1H1 are the cause of mental retardation autosomal dominant type 13 (MRD13). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD13 is associated with variable neuronal migration defects and mild dysmorphic features. Some patients may also show signs of peripheral neuropathy, such as abnormal gait and hyporeflexia. Defects in DYNC1H1 are the cause of spinal muscular atrophy, lower extremity, autosomal dominant (SMALED). A form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMALED is characterized by muscle weakness predominantly affecting the proximal lower extremities. Belongs to the dynein heavy chain family. Note: This description may include information from UniProtKB.
Protein type: Motor protein; Microtubule binding protein; Motility/polarity/chemotaxis
Cellular Component: microtubule; centrosome; cytoplasmic dynein complex; cytosol
Molecular Function: protein binding; ATPase activity; microtubule motor activity; ATP binding
Biological Process: cell death; stress granule assembly; mitotic spindle organization and biogenesis; transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; cytoplasmic mRNA processing body assembly; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule-based movement
Reference #:  Q14204 (UniProtKB)
Alt. Names/Synonyms: Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; DHC1; DHC1a; DKFZp686P2245; DNCH1; Dnchc1; DNCL; DNECL; DYHC; DYHC1; DYNC1H1; Dynein heavy chain, cytosolic; dynein, cytoplasmic 1, heavy chain 1; dynein, cytoplasmic, heavy polypeptide 1; dynein, cytoplasmic-like; HL-3; KIAA0325; p22
Gene Symbols: DYNC1H1
Molecular weight: 532,408 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
Select Structure to View Below

DNCH1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2-p ______MsEPGGGGG
0 1 S13-p GGGGEDGsAGLEVSA
0 1 K32 ADVSVLQKHLRKLVP
0 7 K59-u LEAALEEkSALEQMR
0 1 K67-u SALEQMRkFLsDPQV
0 1 S70-p EQMRkFLsDPQVHTV
0 1 K85-u LVERSTLkEDVGDEG
0 3 K120-u SNSLAFIkRTPVIDA
0 1 T240-p GDKVEDPtFLNQLQS
0 1 K371-a LRKIRNTkYPIQRAL
0 1 K394-a DLSSQLLkVLGTRKL
0 3 K394-u DLSSQLLkVLGTRKL
0 6 K576-u RDQLGTAkNANEMFR
0 1 K613-u TQLIQRVkDDIESLH
0 2 K652-u SGSIIWAkQIDRQLT
0 3 K671-u RVEDVLGkGWENHVE
0 5 K683-u HVEGQKLkQDGDSFR
0 2 K692-u DGDSFRMkLNTQEIF
0 2 K734-u GRTGNVLkLkVNFLP
0 6 K736-u TGNVLkLkVNFLPEI
0 12 K748-u PEIITLSkEVRNLkW
0 1 K754-a SkEVRNLkWLGFRVP
0 3 K754-u SkEVRNLkWLGFRVP
0 2 K809-u SLLVAGLkKEVQALI
0 2 Y970-p RITNQVIyLNPPIEE
0 81 Y1010-p RYQVGVHyELTEEEK
0 2 K1078-u RLGEDLNkWQALLVQ
0 1 K1100 FDNAETKKEFGPVVI
0 1 K1125-a LKYDSWHkEVLSKFG
0 2 S1175-p TFITYVQsLKRKIKQ
0 3 S1230-p DIMRRKDsAIQQQVA
0 1 K1286-a ALTIYEGkFGRLKDD
0 7 K1330-u LEELQDLkGVWSELS
0 1 K1347-u WEQIDQMkEQPWVSV
0 1 K1371-u DALLNQLkSFPARLR
0 2 K1496-u GWDDLFNkVkEHINS
0 1 K1498-u DDLFNkVkEHINSVS
0 2 K1584-u ALMKKVSkSPLVMDV
0 1 K1912-u FGPAGTGkTESVKAL
0 2 T2042-p LFRSLAMtKPDRQLI
0 1 K2068-u TAEVLANkIVPFFKL
0 1 S2095-p FGLRALKsVLVsAGN
0 2 S2099-p ALKsVLVsAGNVKRE
0 2 K2261-u IDPKAISkDHLyGtL
0 1 Y2265-p AISkDHLyGtLDPNt
0 1 T2267-p SkDHLyGtLDPNtRE
0 1 T2272-p yGtLDPNtREWtDGL
0 1 T2276-p DPNtREWtDGLFtHV
0 1 T2281-p EWtDGLFtHVLRKII
0 1 K2349-u MFEVQDLkYATLATV
0 1 K2401-u AQRRRKGkEDEGEEA
0 1 S2410-p DEGEEAAsPMLQIQR
0 1 S2503-p YAILWSLsGDSRLKM
0 2 K2702-u TSDQTWVkLERIQFV
0 2 K2856-u NIDTVALkHFPNIDR
0 1 K2879-u LYSNWLSkDYIPVDQ
0 1 K2894 EELRDYVKARLKVFY
0 1 K2966-u YQIKVHRkYTGEDFD
0 1 K2989 RSGCKNEKIAFIMDE
0 1 K3039 QCKEGAQKEGLMLDS
0 3 Y3103-p DWSTEALyQVGKEFT
0 1 Y3183 YLDFINHYANLFHEK
1 0 K3207-s HLNVGLRkIKETVDQ
0 1 K3284-u SVKEDLDkVEPAVIE
0 3 S3309-p QHLVEVRsMANPPAA
0 2 K3369-u AIREKMKkNYMSNPS
0 1 Y3371 REKMKkNYMSNPSyN
0 1 S3376 kNYMSNPSyNyEIVN
0 15 Y3377-p NYMSNPSyNyEIVNR
0 59 Y3379-p MSNPSyNyEIVNRAs
0 1 S3386-p yEIVNRAsLACGPMV
0 1 K3407 LNYADMLKRVEPLRN
0 1 K3429-u DAKDNQQkANEVEQM
0 1 S3443-p MIRDLEAsIARYKEE
0 1 K3448 EAsIARYKEEYAVLI
0 2 S3475-p VEAKVNRsTALLkSL
0 1 K3480-a NRsTALLkSLSAERE
0 5 K3581-u TENAIMLkRFNRYPL
0 1 K3605-u EFIMNEYkDRKITRT
0 16 K3621-u FLDDAFRkNLESALR
0 3 K3747-u LRLRQLEkSLLQALN
0 5 K3757-u LQALNEVkGRILDDD
0 1 T3769 DDDTIITTLENLkRE
0 9 K3774-u ITTLENLkREAAEVT
0 1 T3781 kREAAEVTRKVEETD
0 2 K4089-u KAINTAVkSGRWVML
0 1 T4127-p ACFRLFLtMEINPKV
0 2 K4154-u FEPPPGVkANMLRTF
0 1 S4162-p ANMLRTFsSIPVSRI
0 1 T4218 DLRSACDTVDTWLDD
0 1 T4221 SACDTVDTWLDDTAK
0 2 T4226 VDTWLDDTAKGRQNI
0 1 S4234-p AKGRQNIsPDkIPWS
0 1 K4237-u RQNIsPDkIPWSALK
0 6 K4283-a RSFDSEFkLACKVDG
0 1 K4362-u LAYAETEkKtRtDst
0 2 T4364-p YAETEkKtRtDstsD
0 23 T4366-p ETEkKtRtDstsDGR
0 163 S4368-p EkKtRtDstsDGRPA
0 38 T4369-p kKtRtDstsDGRPAW
0 63 S4370-p KtRtDstsDGRPAWM
0 14 K4406-u KRTVENIkDPLFRFF
0 2 Y4447-p GKKKQTNyLRTLINE
0 1 K4487 SDFSERIKQLQNISL
0 1 S4603-p TNTEKKAsVVTLPVY
  mouse

 
S2 ______MSEPGGGED
S11 PGGGEDGSAGLEVSA
K30-u ADVAVLQkHLRKLVP
K57-u LEAALEEkSALEQMR
K65 SALEQMRKFLSDPQV
S68 EQMRKFLSDPQVHTV
K83 LVERSTLKEDVGDEG
K118 SNSLAFIKRAPVIDA
T238 GDKVEDPTFLNQLQS
K369 LRKIRNTKYPIQRAL
K392 DLSSQLLKVLGTRKL
K392 DLSSQLLKVLGTRKL
K574-u RDQLGTAkNANEMFR
K611 TQLIQRVKDDIESLH
K650-u SGSIIWAkQIDRQLT
K669 RVEDVLGKGWENHVE
K681 HVEGQKLKQDGDSFR
K690 DGDSFRMKLNTQEIF
K732 GRTGNVLKLkVNFLP
K734-u TGNVLKLkVNFLPEI
K746-u PEIITLSkEVRNLKW
K752 SkEVRNLKWLGFRVP
K752 SkEVRNLKWLGFRVP
K807-u SLLVAGLkKEVQALI
Y968 RITNQVIYLNPPIEE
Y1008-p RYQVGVHyELTEEEK
K1076 RLGEDLNKWQALLVQ
K1098-u FDNAETKkEFGPVVI
K1123 LKYDSWHKEVLSKFG
S1173 TFITYVQSLKRKIKQ
S1228-p DIMRRKDsAIQQQVA
K1284 ALTIYEGKFGRLKDD
K1328-u LEELQDLkGVWSELS
K1345 WEQIDQMKEQPWVSV
K1369 DGLLNQLKNFPARLR
K1494-u GWDDLFNkVKEHINS
K1496 DDLFNkVKEHINSVS
K1582-u ALMKKVSkSPLVMDV
K1910 FGPAGTGKTESVKAL
T2040 LFRSLAMTKPDRQLI
K2066 TAEVLANKIVPFFKL
S2093 FGLRALKSVLVSAGN
S2097 ALKSVLVSAGNVKRE
K2259 IDPKAISKDHLYGTL
Y2263 AISKDHLYGTLDPNT
T2265 SKDHLYGTLDPNTRE
T2270 YGTLDPNTREWTDGL
T2274 DPNTREWTDGLFTHV
T2279 EWTDGLFTHVLRKII
K2347 MFEVQDLKYATLATV
K2399 AQRRRKGKEDEGEEA
S2408 DEGEEAASPMLQIQR
S2501 YAILWSLSGDSRLKM
K2700 TSDQTWVKLERIQFV
K2854 NIDMVALKHFPNIDK
K2877 LYSNWLSKDYIPVDQ
K2892-u EELRDYVkARLKVFY
K2964 YQIKVHRKYTGEDFD
K2987-u RSGCKNEkIAFIMDE
K3037-u QCKEGAQkEGLMLDS
Y3101 DWSTEALYQVGKEFT
Y3181-p YLDFINHyANLFHEK
K3205 HLNVGLRKIKETVDQ
K3282 SVKEDLDKVEPAVIE
S3307 QHLVEVRSMANPPAA
K3367-u AIREKMKkNyMSNPs
Y3369-p REKMKkNyMSNPsyN
S3374-p kNyMSNPsyNyEIVN
Y3375-p NyMSNPsyNyEIVNR
Y3377-p MSNPsyNyEIVNRAS
S3384 yEIVNRASLACGPMV
K3405-u LNYADMLkRVEPLRN
K3427 DAKDNQQKANEVEQM
S3441 MIRDLEASIARYkEE
K3446-u EASIARYkEEYAVLI
S3473 VEAKVNRSTALLKSL
K3478 NRSTALLKSLSAERE
K3579-u TENAIMLkRFNRYPL
K3603 EFIMNEYKDRKITRT
K3619-u FLDDAFRkNLESALR
K3745-u LRLRQLEkSLLQALN
K3755-u LQALNEVkGRILDDD
T3767-p DDDTIITtLENLkRE
K3772-u ITtLENLkREAAEVt
T3779-p kREAAEVtRKVEETD
K4087 KAINTAVKSGRWVML
T4125 ACFRLFLTMEINPKV
K4152 FEPPPGVKANMLRTF
S4160 ANMLRTFSSIPVSRI
T4216-p DLRSACDtVDtWLDD
T4219-p SACDtVDtWLDDtAK
T4224-p VDtWLDDtAKGRQNI
S4232 AKGRQNISPDKIPWS
K4235 RQNISPDKIPWSALK
K4281 RSFDSEFKLACKVDG
K4360 LAYAETEKKARtDst
A4362 YAETEKKARtDstsD
T4364-p ETEKKARtDstsDGR
S4366-p EKKARtDstsDGRPA
T4367-p KKARtDstsDGRPAW
S4368-p KARtDstsDGRPAWM
K4404-u KRTVENIkDPLFRFF
Y4445 GKKKQTNYLRTLINE
K4485-u SDFSERIkQLQNISQ
S4601 TSAEKKASVVTLPVY
  rat

 
S2 ______MSETGGGED
S11 TGGGEDGSAGLEVSA
K30 ADVSVLQKHLRKLVP
K57 LEAALEEKSALEQMR
K65 SALEQMRKFLSDPQV
- under review  
K83 LVERSTLKEDVGDEG
K118 SNSLAFIKRAPVIDA
T238 GDKVEDPTFLNQLQS
K369 LRKIRNTKYPIQRAL
K392 DLSSQLLKVLGTRKL
K392 DLSSQLLKVLGTRKL
K574 RDQLGTAKNANEMFR
K611 TQLIQRVKDDIESLH
K650 SGSIIWAKQIDRQLT
K669 RVEDVLGKGWENHVE
K681 HVEGQKLKQDGDSFR
K690 DGDSFRMKLNTQEIF
K732 GRSGNVLKLKVNFLP
K734 SGNVLKLKVNFLPEI
K746 PEIITLSKEVRNLKW
K752 SKEVRNLKWLGFRVP
K752 SKEVRNLKWLGFRVP
K807 SLLVAGLKKEVQALI
Y968 RITNQVIYLNPPIEE
Y1008 RYQVGVHYELTEEEK
K1076 RLGEDLSKWQALLVQ
K1098 FDNAETKKEFGPVVI
K1123 LKYDSWHKEVLSKFG
S1173 TFITYVQSLKRKIKQ
S1228-p DIMRRKDsAIQQQVA
K1284 ALTIYEGKFGRLKDD
K1328 LEELQDLKGVWSELS
K1345 WEQIDQMKEQPWVSV
K1369 DGLLNQLKNFPARLR
K1494 GWDDLFNKVKEHINS
K1496 DDLFNKVKEHINSVS
K1582 ALMKKVSKSPLVMDV
K1910 FGPAGTGKTESVKAL
T2040 LFRSLAMTKPDRQLI
K2066 TAEVLANKIVPFFKL
S2093 FGLRALKSVLVSAGN
S2097 ALKSVLVSAGNVKRE
K2259 IDPKAISKDHLYGTL
Y2263 AISKDHLYGTLDPNT
T2265 SKDHLYGTLDPNTRE
T2270 YGTLDPNTREWTDGL
T2274 DPNTREWTDGLFTHV
T2279 EWTDGLFTHVLRKII
K2347 MFEVQDLKYATLATV
K2399 AQRRRKGKEDEGEEA
S2408 DEGEEAASPMLQIQR
S2501 YAILWSLSGDSRLKM
K2700 TSDQTWVKLERIQFV
K2854 NIDMVALKHFPNIDK
K2877 LYSNWLSKDYIPVDQ
K2892 EELRDYVKARLKVFY
K2964 YQIKVHRKYTGEDFD
K2987 RSGCKNEKIAFIMDE
K3037 QCKEGAQKEGLMLDS
Y3101 DWSTEALYQVGKEFT
- under review  
K3205 HLNVGLRKIKETVDQ
K3282 SVKEDLDKVEPAVIE
S3307 QHLVEVRSMANPPAA
K3367 AIREKMKKNYMSNPS
Y3369 REKMKKNYMSNPSYN
S3374 KNYMSNPSYNyEIVN
Y3375 NYMSNPSYNyEIVNR
Y3377-p MSNPSYNyEIVNRAS
S3384 yEIVNRASLACGPMV
K3405 LNYADMLKRVEPLRN
K3427 DAKDNQQKANEVEQM
S3441 MIRDLEASIARYKEE
K3446 EASIARYKEEYAVLI
S3473 VEAKVNRSTALLKSL
K3478 NRSTALLKSLSAERE
K3579 TENAIMLKRFNRYPL
K3603 EFIMNEYKDRKITRT
K3619 FLDDAFRKNLESALR
K3745 LRLRQLEKSLLQALN
K3755 LQALNEVKGRILDDD
T3767 DDDTIITTLENLKRE
K3772 ITTLENLKREAAEVT
T3779 KREAAEVTRKVEETD
K4087 KAINTAVKSGRWVML
T4125 ACFRLFLTMEINPKV
K4152 FEPPPGVKANMLRTF
- under review  
T4216 DLRSACDTVDTWLDD
T4219 SACDTVDTWLDDTAK
T4224 VDTWLDDTAKGRQNI
- under review  
K4235 RQNISPDKIPWSALK
K4281 RSFDSEFKLACKVDG
K4360 LAYAETEKKTRTDsT
T4362 YAETEKKTRTDsTSD
T4364 ETEKKTRTDsTSDGR
S4366-p EKKTRTDsTSDGRPA
T4367 KKTRTDsTSDGRPAW
S4368 KTRTDsTSDGRPAWM
K4404 KRTVENIKDPLFRFF
Y4445-p GKKKQTNyLRTLINE
K4485 SDFSERIKQLQNISQ
S4601 TSAEKKASVVTLPVY
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