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Protein Page:
HDAC3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HDAC3 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2. Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Component of the Notch corepressor complex. Interacts with CBFA2T3 and NKAP. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with and deacetylates MAPK14. Interacts with ZMYND15. Widely expressed. Belongs to the histone deacetylase family. HD type 1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Cell cycle regulation; EC 3.5.1.98; Deacetylase; Apoptosis
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: nucleoplasm; transcriptional repressor complex; spindle microtubule; cytoplasm; histone deacetylase complex; nucleus
Molecular Function: protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); cyclin binding; enzyme binding; NAD-dependent histone deacetylase activity (H3-K14 specific); chromatin DNA binding; histone deacetylase binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); chromatin binding; histone deacetylase activity; transcription corepressor activity; transcription factor binding
Biological Process: negative regulation of JNK cascade; Notch signaling pathway; transcription, DNA-dependent; nerve growth factor receptor signaling pathway; regulation of mitotic cell cycle; regulation of multicellular organism growth; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; spindle assembly; chromatin modification; negative regulation of cell cycle; protein amino acid deacetylation; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
Reference #:  O15379 (UniProtKB)
Alt. Names/Synonyms: HD3; HDAC3; Histone deacetylase 3; RPD3; RPD3-2; SMAP45
Gene Symbols: HDAC3
Molecular weight: 48,848 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
CST Pathways:  Crosstalk between PTMs  |  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HDAC3

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S424‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y18 PDVGNFHYGAGHPMK
0 1 K44-ub LHYGLYKkMIVFKPY
0 1 S74-p IDFLQRVsPTNMQGF
0 1 Y331-p PYSEYFEyFAPDFTL
0 2 Y404-p ERGPEENySRPEAPN
0 1 Y414 PEAPNEFYDGDHDND
1 14 S424-p DHDNDKEsDVEI___
3815 : Phospho-HDAC3 (Ser424) Antibody
  mouse

 
Y18-p PDVGNFHyGAGHPMK
K44 LHYGLYKKMIVFKPY
S74 IDFLQRVSPTNMQGF
Y331 PYSEYFEYFAPDFTL
Y404 ERGPEENYSRPEAPN
Y414-p PEAPNEFyDGDHDND
S424-p DHDNDKEs_______
3815 : Phospho-HDAC3 (Ser424) Antibody
  rat

 
Y18 PDVGNFHYGAGHPMK
K44 LHYGLYKKMIVFKPY
S74 IDFLQRVSPTNMQGF
Y331 PYSEYFEYFAPDFTL
Y404 ERGPEENYSRPEAPN
Y414 PEAPNEFYDGDHDND
S424-p DHDNDKEsDVEI___
3815 : Phospho-HDAC3 (Ser424) Antibody
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