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HDAC3 (human)

Overview HDAC3 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2. Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Component of the Notch corepressor complex. Interacts with CBFA2T3 and NKAP. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with and deacetylates MAPK14. Interacts with ZMYND15. Widely expressed. Belongs to the histone deacetylase family. HD type 1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Apoptosis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; EC 3.5.1.98; Deacetylase; Cell cycle regulation Cellular Component: nucleoplasm; transcriptional repressor complex; spindle microtubule; cytoplasm; histone deacetylase complex; chromatin; nucleus Molecular Function: protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); enzyme binding; NAD-dependent histone deacetylase activity (H3-K14 specific); chromatin DNA binding; histone deacetylase binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription corepressor activity; transcription factor binding Biological Process: response to drug; negative regulation of JNK cascade; Notch signaling pathway; transcription, DNA-dependent; nerve growth factor receptor signaling pathway; regulation of mitotic cell cycle; regulation of multicellular organism growth; spindle assembly; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; cellular lipid metabolic process; negative regulation of cell cycle; protein amino acid deacetylation; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis Reference #:  O15379 (UniProtKB) Alt. Names/Synonyms: HD3; HDAC3; Histone deacetylase 3; RPD3; RPD3-2; SMAP45 Gene Symbols: HDAC3 Molecular weight: 48,848 Da Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HDAC3 4A69 - A/B=1-376 (human)

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	Sites Implicated In
enzymatic activity, induced: S424‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y18	PDVGNFHYGAGHPMK
0	1		K44-u	LHYGLYKkMIVFKPY
0	1		Y331-p	PYSEYFEyFAPDFTL
0	2		Y404-p	ERGPEENySRPEAPN
0	1		Y414	PEAPNEFYDGDHDND
1	9		S424-p	DHDNDKEsDVEI___

	mouse
Y18-p	PDVGNFHyGAGHPMK
K44	LHYGLYKKMIVFKPY
Y331	PYSEYFEYFAPDFTL
Y404	ERGPEENYSRPEAPN
Y414-p	PEAPNEFyDGDHDND
S424-p	DHDNDKEsDVEI___

	rat
Y18	PDVGNFHYGAGHPMK
K44	LHYGLYKKMIVFKPY
Y331	PYSEYFEYFAPDFTL
Y404	ERGPEENYSRPEAPN
Y414	PEAPNEFYDGDHDND
S424	DHDNDKESDVEI___

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