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Protein Page:
PRKX (human)

Overview
PRKX Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; PKA family
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; cAMP-dependent protein kinase activity; ATP binding
Biological Process: regulation of cell adhesion; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; endothelial cell proliferation; endothelial cell migration; myeloid cell differentiation; angiogenesis; cell adhesion; regulation of cell migration; cell-substrate adhesion
Reference #:  P51817 (UniProtKB)
Alt. Names/Synonyms: PKX1; PRKX; Protein kinase PKX1; protein kinase, X-linked; Serine/threonine-protein kinase PRKX
Gene Symbols: PRKX
Molecular weight: 40,896 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
Select Structure to View Below

PRKX

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 11 T201-p AKKLVDRtWtLCGTP
0 27 T203-p KLVDRtWtLCGTPEY
0 1 S305-p KHHRWFRsVDWEAVP
  mouse

 
T198-p AKKLVDRtWtLCGTP
T200-p KLVDRtWtLCGTPEY
G302 KRHRWFRGVEWESVP
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