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Protein Page:
VAV3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VAV3 a guanine nucleotide exchange factor (GEF) that activates RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by activated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion. Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation. Down-regulated by EGF and TGF-beta. Four isoforms of the human protein are produced by alternative promoter. Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Actin binding protein; Motility/polarity/chemotaxis; GEFs, Rac/Rho; GEFs; Adaptor/scaffold
Cellular Component: plasma membrane; cytosol
Molecular Function: protein binding; SH3/SH2 adaptor activity; guanyl-nucleotide exchange factor activity; metal ion binding; Rac guanyl-nucleotide exchange factor activity; GTPase activator activity; epidermal growth factor receptor binding
Biological Process: response to drug; integrin-mediated signaling pathway; lamellipodium biogenesis; platelet activation; cell migration; positive regulation of cell adhesion; positive regulation of signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of phosphoinositide 3-kinase activity; vesicle fusion; B cell receptor signaling pathway; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of B cell proliferation; innate immune response; angiogenesis; blood coagulation; regulation of Rac GTPase activity; response to DNA damage stimulus; positive regulation of GTPase activity
Reference #:  Q9UKW4 (UniProtKB)
Alt. Names/Synonyms: FLJ40431; Guanine nucleotide exchange factor VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3; VAV3
Gene Symbols: VAV3
Molecular weight: 97,776 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VAV3

Protein Structure Not Found.


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Sites Implicated In
activity, induced: Y173‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T131-p TGIRPFPtEEsINDE
0 1 S134-p RPFPtEEsINDEDIy
0 6 Y141-p sINDEDIyKGLPDLI
4 0 Y173-p EDEGGEVyEDLMKAE
0 1 Y207-p IKQTEEKytEtLEsI
0 1 T208-p KQTEEKytEtLEsIE
0 1 T210-p TEEKytEtLEsIEKy
0 2 S213-p KytEtLEsIEKyFMA
0 2 Y217-p tLEsIEKyFMAPLKR
0 1 Y294-p SAISSLDyIsKtKED
0 1 S296-p ISSLDyIsKtKEDVK
0 1 T298-p SLDyIsKtKEDVKLK
0 1 K317 SKRANNGKFTLRDLL
0 8 K333-ub VPMQRVLkYHLLLQE
0 1 Y508-p LSNIRPDyADsNFHD
0 1 S511-p IRPDyADsNFHDFKM
0 4 Y539-p MLLRGTFyQGYLCFK
0 3 S567-p DNCGRVNsGEQGtLK
0 6 T572-p VNsGEQGtLKLPEKR
0 2 T606-p VIRNYSGtPPPALHE
0 3 Y667-p CVPKPVDySCQPWYA
0 7 Y706-p RTKESGEyAISIKYN
0 1 K711 GEyAISIKYNNEAKH
0 1 K717 IKYNNEAKHIKILTR
0 1 K720 NNEAKHIKILTRDGF
0 1 K735-m2 FHIAENRkFksLMEL
0 1 K737-m2 IAENRkFksLMELVE
0 1 S738-p AENRkFksLMELVEY
0 2 S786-p RAGNSLLsPKVLGIA
0 49 Y797-p LGIAIARyDFCARDM
0 1 Y818-p KGDVVKIyTKMSANG
0 1 S840-p GRVGWFPsTyVEEDE
0 1 Y842-p VGWFPsTyVEEDE__
  mouse

 
T131 TGIRPFPTEESINDE
S134 RPFPTEESINDEDIy
Y141-p SINDEDIyKGLPDLI
Y173-p EDEGGEVyEDLMKAE
Y207 IRQTEEKYTETLESI
T208 RQTEEKYTETLESIE
T210 TEEKYTETLESIEKY
S213 KYTETLESIEKYFMA
Y217 TLESIEKYFMAPLKR
Y294 SAISNLDYISKTKED
S296 ISNLDYISKTKEDVK
T298 NLDYISKTKEDVKLK
K317-ac SKRANNGkFTLRDLL
K333 VPMQRVLKYHLLLQE
Y508 LSNIRPDYADSNFHD
S511 IRPDYADSNFHDFKM
Y539 MLLRGTFYQGYLCFK
S567 DNCGRVNSVEQGPFK
P572 VNSVEQGPFKPPEKR
T606 VIRNYTGTPAPGLHE
Y667 CVPKPVDYSCQPWYA
Y706 RTKESGEYAISIKYN
K711 GEYAISIKYNNEAkH
K717-ac IKYNNEAkHIkILTR
K720-ac NNEAkHIkILTRDGF
K735 FHIAENRKFKSLMEL
K737 IAENRKFKSLMELVE
S738 AENRKFKSLMELVEY
S786-p RTGNSLLsPKVLGIA
Y797-p LGIAIARyDFCARDM
Y818 KGDMVKIYTKMSANG
S840 GRVGWFPSTYVEEDE
Y842 VGWFPSTYVEEDE__
  rat

 
T131 TGIRPFPTEESVNDE
S134 RPFPTEESVNDEDIY
Y141 SVNDEDIYKGLPDLI
Y173 EDEGGEVYEDLMKAE
Y207 IRQTEEKYTETLESI
T208 RQTEEKYTETLESIE
T210 TEEKYTETLESIEKY
S213 KYTETLESIEKYFMA
Y217 TLESIEKYFMAPLKR
Y294 SAISSLDYISKTKED
S296 ISSLDYISKTKEDVR
T298 SLDYISKTKEDVRLK
K317 SKRANNGKFTLRDLL
K333 VPMQRVLKYHLLLQE
Y508 LSNIRPDYADSNFHD
S511 IRPDYADSNFHDFKM
Y539 MLLRGTFYQGYLCFK
S567 DNCGRVNSVEQGPFK
P572 VNSVEQGPFKPPEKR
T606 VIRNYTGTPPPALHE
Y667 CVPKPVDYSCQPWYA
Y706 RTKESGEYAISIkYN
K711-ub GEYAISIkYNNEAKH
K717 IkYNNEAKHIKILTR
K720 NNEAKHIKILTRDGF
K735 FHIAENRKFKSLMEL
K737 IAENRKFKSLMELVE
S738 AENRKFKSLMELVEY
S786 RTGNSLLSPKVLGIA
Y797 LGIAIARYDFCARDM
Y818 KGDMVKIYTKMSANG
S840 GRVGWFPSTYVEEDE
Y842 VGWFPSTYVEEDE__
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