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VAV3
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1- induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)- mediated adhesion. Does not affect integrin beta-1 (ITGB1)- mediated adhesion. Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation. Down-regulated by EGF and TGF-beta. Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable. 4 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Activator protein; Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Actin binding protein |
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Cellular Component: plasma membrane; cytosol
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Molecular Function: protein binding; SH3/SH2 adaptor activity; metal ion binding; Rac guanyl-nucleotide exchange factor activity; phospholipid binding; GTPase activator activity; epidermal growth factor receptor binding
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Biological Process: integrin-mediated signaling pathway; response to drug; lamellipodium biogenesis; platelet activation; cell migration; positive regulation of cell adhesion; nerve growth factor receptor signaling pathway; apoptosis; positive regulation of phosphoinositide 3-kinase activity; vesicle fusion; B cell receptor signaling pathway; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; regulation of Rho protein signal transduction; positive regulation of B cell proliferation; angiogenesis; blood coagulation; response to DNA damage stimulus; positive regulation of GTPase activity
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Reference #:
Q9UKW4 (UniProtKB)
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| Alt. Names/Synonyms: FLJ40431; Guanine nucleotide exchange factor VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3; VAV3 |
| Gene Symbols: VAV3 |
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Molecular weight: 97,776 Da
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Basal Isoelectric point: 6.65
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Regulation of Actin Dynamics
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T Cell Receptor Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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