Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
VAV3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
VAV3 a guanine nucleotide exchange factor (GEF) that activates RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by activated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion. Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation. Down-regulated by EGF and TGF-beta. Four isoforms of the human protein are produced by alternative promoter. Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; GEFs, Rac/Rho; Adaptor/scaffold; Actin binding protein; GEFs
Cellular Component: plasma membrane; cytosol
Molecular Function: protein binding; SH3/SH2 adaptor activity; metal ion binding; guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; GTPase activator activity; epidermal growth factor receptor binding
Biological Process: response to drug; integrin-mediated signaling pathway; lamellipodium biogenesis; platelet activation; cell migration; positive regulation of cell adhesion; nerve growth factor receptor signaling pathway; positive regulation of signal transduction; positive regulation of apoptosis; positive regulation of phosphoinositide 3-kinase activity; vesicle fusion; regulation of small GTPase mediated signal transduction; B cell receptor signaling pathway; small GTPase mediated signal transduction; positive regulation of B cell proliferation; innate immune response; angiogenesis; blood coagulation; response to DNA damage stimulus; positive regulation of GTPase activity
Reference #:  Q9UKW4 (UniProtKB)
Alt. Names/Synonyms: FLJ40431; Guanine nucleotide exchange factor VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3; VAV3
Gene Symbols: VAV3
Molecular weight: 97,776 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VAV3

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
activity, induced: Y173‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T131-p TGIRPFPtEEsINDE
0 1 S134-p RPFPtEEsINDEDIy
0 6 Y141-p sINDEDIyKGLPDLI
4 0 Y173-p EDEGGEVyEDLMKAE
0 2 S213-p KYTETLEsIEKyFMA
0 2 Y217-p TLEsIEKyFMAPLKR
0 8 K333-u VPMQRVLkYHLLLQE
0 1 Y508-p LSNIRPDyADsNFHD
0 1 S511-p IRPDyADsNFHDFKM
0 4 Y539-p MLLRGTFyQGYLCFK
0 3 S567-p DNCGRVNsGEQGtLK
0 6 T572-p VNsGEQGtLKLPEKR
0 2 T606-p VIRNYSGtPPPALHE
0 3 Y667-p CVPKPVDySCQPWYA
0 7 Y706-p RTKESGEyAISIKYN
0 1 K735-m2 FHIAENRkFkSLMEL
0 1 K737-m2 IAENRkFkSLMELVE
0 1 S786-p RAGNSLLsPKVLGIA
0 59 Y797-p LGIAIARyDFCARDM
  mouse

 
T131 TGIRPFPTEESINDE
S134 RPFPTEESINDEDIy
Y141-p SINDEDIyKGLPDLI
Y173-p EDEGGEVyEDLMKAE
S213 KYTETLESIEKYFMA
Y217 TLESIEKYFMAPLKR
K333 VPMQRVLKYHLLLQE
Y508 LSNIRPDYADSNFHD
S511 IRPDYADSNFHDFKM
Y539 MLLRGTFYQGYLCFK
S567 DNCGRVNSVEQGPFK
P572 VNSVEQGPFKPPEKR
T606 VIRNYTGTPAPGLHE
Y667 CVPKPVDYSCQPWYA
Y706 RTKESGEYAISIKYN
K735 FHIAENRKFKSLMEL
K737 IAENRKFKSLMELVE
S786-p RTGNSLLsPKVLGIA
Y797-p LGIAIARyDFCARDM
  rat

 
T131 TGIRPFPTEESVNDE
S134 RPFPTEESVNDEDIY
Y141 SVNDEDIYKGLPDLI
Y173 EDEGGEVYEDLMKAE
S213 KYTETLESIEKYFMA
Y217 TLESIEKYFMAPLKR
K333 VPMQRVLKYHLLLQE
Y508 LSNIRPDYADSNFHD
S511 IRPDYADSNFHDFKM
Y539 MLLRGTFYQGYLCFK
S567 DNCGRVNSVEQGPFK
P572 VNSVEQGPFKPPEKR
T606 VIRNYTGTPPPALHE
Y667 CVPKPVDYSCQPWYA
Y706 RTKESGEYAISIKYN
K735 FHIAENRKFKSLMEL
K737 IAENRKFKSLMELVE
S786 RTGNSLLSPKVLGIA
Y797 LGIAIARYDFCARDM
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.