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Protein Page:
UGT1A7 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
UGT1A7 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 2.4.1.17; Carbohydrate Metabolism - ascorbate and aldarate; Lipid Metabolism - androgen and estrogen; Cofactor and Vitamin Metabolism - retinol; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Xenobiotic Metabolism - drug metabolism - other enzymes; Membrane protein, integral
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: enzyme inhibitor activity; retinoic acid binding; protein homodimerization activity; enzyme binding; protein kinase C binding; protein heterodimerization activity; glucuronosyltransferase activity; drug binding
Biological Process: coumarin metabolic process; negative regulation of catalytic activity; flavone metabolic process; retinoic acid metabolic process; negative regulation of fatty acid metabolic process; drug metabolic process; excretion
Reference #:  Q9HAW7 (UniProtKB)
Alt. Names/Synonyms: GNT1; UD17; UDP glucuronosyltransferase 1 family, polypeptide A7; UDP glycosyltransferase 1 family, polypeptide A7; UDP-glucuronosyltransferase 1 family polypeptide A7s; UDP-glucuronosyltransferase 1-7; UDP-glucuronosyltransferase 1-G; UDP-glucuronosyltransferase 1A7; UDPGT; UDPGT 1-7; UGT-1G; UGT1; UGT1*7; UGT1-07; UGT1.7; UGT1A7; UGT1G
Gene Symbols: UGT1A7
Molecular weight: 59,819 Da
Basal Isoelectric point: 7.88  Predict pI for various phosphorylation states
Select Structure to View Below

UGT1A7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 A96 EFMVFADARWTAPLR
0 1 S104 RWTAPLRSAFSLLTS
0 1 S107 APLRSAFSLLTSSSN
0 1 S112 AFSLLTSSSNGIFDL
0 4 K350 ANNTILVKWLPQNDL
1 0 S432-p KAVINDKsYKENIMR
  mouse

 
T94-p EFKYLSYtQWKTPEH
S102-p QWKTPEHsIRsFLTG
S105-p TPEHsIRsFLTGsAR
S110-p IRsFLTGsARGFFEL
K348-a AKNTILVkWLPQNDL
S430 KTVINNKSYKENIMR
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