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Protein Page:
GATA2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GATA2 Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus
Molecular Function: protein binding; zinc ion binding; chromatin binding; transcription factor activity; transcription factor binding
Biological Process: embryonic placenta development; somatic stem cell maintenance; cell maturation; negative regulation of transcription from RNA polymerase II promoter; cell fate determination; cell differentiation in hindbrain; positive regulation of phagocytosis; positive regulation of megakaryocyte differentiation; central nervous system neuron development; inner ear morphogenesis; transcription, DNA-dependent; positive regulation of erythrocyte differentiation; neuron fate commitment; regulation of histone acetylation; negative regulation of fat cell differentiation; phagocytosis; positive regulation of angiogenesis; negative regulation of macrophage differentiation; pituitary gland development; homeostasis of number of cells within a tissue; ventral spinal cord interneuron differentiation; negative regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; urogenital system development
Reference #:  P23769 (UniProtKB)
Alt. Names/Synonyms: Endothelial transcription factor GATA-2; FLJ45948; GATA binding protein 2; GATA-binding protein 2; GATA2; MGC2306; NFE1B
Gene Symbols: GATA2
Molecular weight: 50,500 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GATA2

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S401‑p
transcription, altered: S401‑p
activity, inhibited: S401‑p
intracellular localization: S401‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S71-p AHARARVsYsPAHAR
1 3 S73-p ARARVsYsPAHARLT
0 1 R86-m2 LTGGQMCrPHLLHSP
1 0 S119-p HHNPWTVsPFSKTPL
0 1 S186-p KEVSPDPsTTGAAsP
1 2 S192-p PsTTGAAsPASSSAG
0 1 S216-p DGVKYQVsLTESMKM
0 1 S276-p GFLGGPAsSFTPKQR
1 0 S290-p RSKARSCsEGRECVN
0 2 Y314-p RRDGTGHyLCNACGL
0 3 Y322-p LCNACGLyHKMNGQN
0 1 K390 NRPLTMKKEGIQTRN
1 5 S401-p QTRNRKMsNKSKKSK
  mouse

 
S71 AHARARVSYsPAHAR
S73-p ARARVSYsPAHARLT
R86 LTGGQMCRPHLLHSP
S119 HHSPWTVSPFSKTPL
S186 KEVSPDPSTTGAAsP
S192-p PSTTGAAsPASSSAG
S216 DGVKYQVSLSESMKM
S276 GFLGGPASSFTPKQR
S290 RSKARSCSEGRECVN
Y314 RRDGTGHYLCNACGL
Y322 LCNACGLYHKMNGQN
K390-ac NRPLTMKkEGIQTRN
S401-p QTRNRKMsSKSKKSK
  rat

 
S71 AHARARVSYSPAHAR
S73 ARARVSYSPAHARLT
R86 LTGGQMCRPHLLHSP
S119 HHSPWTVSPFSKTPL
S186 KEVSPDPSTTGAASP
S192 PSTTGAASPASPSAG
S216 DGVKYQVSLSESMKM
S276 GFLGGPASSFTPKQR
S290 RSKARSCSEGRECVN
Y314 RRDGTGHYLCNACGL
Y322 LCNACGLYHKMNGQN
K390 NRPLTMKKEGIQTRN
S401 QTRNRKMSSKSKKSK
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