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Protein Page:
GATA2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GATA2 Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: nucleoplasm; protein complex
Molecular Function: protein binding; zinc ion binding; chromatin binding; transcription factor activity; transcription factor binding
Biological Process: embryonic placenta development; inner ear morphogenesis; transcription, DNA-dependent; somatic stem cell maintenance; positive regulation of erythrocyte differentiation; cell maturation; neuron fate commitment; regulation of histone acetylation; cell fate determination; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation; phagocytosis; positive regulation of angiogenesis; cell differentiation in hindbrain; negative regulation of macrophage differentiation; homeostasis of number of cells within a tissue; ventral spinal cord interneuron differentiation; pituitary gland development; positive regulation of phagocytosis; negative regulation of Notch signaling pathway; positive regulation of megakaryocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; urogenital system development; central nervous system neuron development
Reference #:  P23769 (UniProtKB)
Alt. Names/Synonyms: Endothelial transcription factor GATA-2; FLJ45948; GATA binding protein 2; GATA-binding protein 2; GATA2; MGC2306; NFE1B
Gene Symbols: GATA2
Molecular weight: 50,500 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GATA2

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell growth, altered: S401‑p
transcription, altered: S401‑p
activity, inhibited: S401‑p
intracellular localization: S401‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S73-p ARARVSYsPAHARLT
0 1 R86-m2 LTGGQMCrPHLLHSP
0 1 S182-p PTPPKEVsPDPsTTG
0 1 S186-p KEVsPDPsTTGAAsP
0 2 S192-p PsTTGAAsPASSSAG
0 1 S216-p DGVKYQVsLTESMKM
0 2 Y314-p RRDGTGHyLCNACGL
0 3 Y322-p LCNACGLyHKMNGQN
0 3 Y376-p VCNACGLyYKLHNVN
1 5 S401-p QTRNRKMsNKSKKSK
  mouse

 
S73-p ARARVSYsPAHARLT
R86 LTGGQMCRPHLLHSP
S182 PTPPKEVSPDPSTTG
S186 KEVSPDPSTTGAAsP
S192-p PSTTGAAsPASSSAG
S216 DGVKYQVSLSESMKM
Y314 RRDGTGHYLCNACGL
Y322 LCNACGLYHKMNGQN
Y376 VCNACGLYYKLHNVN
S401-p QTRNRKMsSKSKKSK
  rat

 
S73 ARARVSYSPAHARLT
R86 LTGGQMCRPHLLHSP
S182-p PTPPKEVsPDPSTTG
S186 KEVsPDPSTTGAASP
S192 PSTTGAASPASPSAG
S216 DGVKYQVSLSESMKM
Y314 RRDGTGHYLCNACGL
Y322 LCNACGLYHKMNGQN
Y376 VCNACGLYYKLHNVN
S401 QTRNRKMSSKSKKSK
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