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GATA2 (human)

Overview GATA2 Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Transcription factor Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus Molecular Function: protein binding; zinc ion binding; chromatin binding; transcription factor activity; transcription factor binding Biological Process: embryonic placenta development; somatic stem cell maintenance; cell maturation; negative regulation of transcription from RNA polymerase II promoter; cell fate determination; cell differentiation in hindbrain; positive regulation of phagocytosis; positive regulation of megakaryocyte differentiation; central nervous system neuron development; inner ear morphogenesis; transcription, DNA-dependent; positive regulation of erythrocyte differentiation; neuron fate commitment; regulation of histone acetylation; negative regulation of fat cell differentiation; phagocytosis; positive regulation of angiogenesis; negative regulation of macrophage differentiation; ventral spinal cord interneuron differentiation; homeostasis of number of cells within a tissue; pituitary gland development; negative regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; urogenital system development Reference #:  P23769 (UniProtKB) Alt. Names/Synonyms: Endothelial transcription factor GATA-2; FLJ45948; GATA binding protein 2; GATA-binding protein 2; GATA2; MGC2306; NFE1B Gene Symbols: GATA2 Molecular weight: 50,500 Da Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GATA2

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	Sites Implicated In
cell growth, altered: S401‑p transcription, altered: S401‑p inhibition: S401‑p intracellular localization: S401‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S182-p	PTPPKEVsPDPSTTG
0	2		S73-p	ARARVSYsPAHARLT
0	1		S192-p	PSTTGAAsPASSSAG
0	1		S195	TGAAsPASSSAGGSA
0	1		S201	ASSSAGGSAARGEDK
0	1		S276-p	GFLGGPAsSFTPKQR
0	2		Y314-p	RRDGTGHyLCNACGL
0	3		Y322-p	LCNACGLyHKMNGQN
0	3		Y376-p	VCNACGLyYKLHNVN
0	1		K390	NRPLTMKKEGIQTRN
1	5		S401-p	QTRNRKMsNKSKKSK

	mouse
S182	PTPPKEVSPDPSTTG
S73-p	ARARVSYsPAHARLT
S192-p	PSTTGAAsPASSSAG
S195	TGAAsPASSSAGGSV
S201	ASSSAGGSVARGEDK
S276	GFLGGPASSFTPKQR
Y314	RRDGTGHYLCNACGL
Y322	LCNACGLYHKMNGQN
Y376	VCNACGLYYKLHNVN
K390-a	NRPLTMKkEGIQTRN
S401-p	QTRNRKMsSKSKKSK

	rat
S182-p	PTPPKEVsPDPSTTG
S73	ARARVSYSPAHARLT
S192	PSTTGAASPAsPSAG
S195-p	TGAASPAsPSAGGsV
S201-p	AsPSAGGsVARGEDK
S276	GFLGGPASSFTPKQR
Y314	RRDGTGHYLCNACGL
Y322	LCNACGLYHKMNGQN
Y376	VCNACGLYYKLHNVN
K390	NRPLTMKKEGIQTRN
S401	QTRNRKMSSKSKKSK

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