Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
TGFBR3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TGFBR3 Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: extracellular space; proteinaceous extracellular matrix; cell surface; integral to plasma membrane; endoplasmic reticulum; external side of plasma membrane
Molecular Function: transforming growth factor beta receptor activity; heparin binding; protein binding; fibroblast growth factor binding; glycosaminoglycan binding; transforming growth factor beta binding; punt binding; activin binding; coreceptor activity; SMAD binding; transforming growth factor beta receptor binding; PDZ domain binding
Biological Process: heart morphogenesis; transforming growth factor beta receptor complex assembly; blood vessel development; organ regeneration; blastocyst development; cell migration; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of cell motility; cardiac muscle cell proliferation; palate development; liver development; activation of NF-kappaB transcription factor; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; regulation of protein binding; response to hypoxia; ventricular cardiac muscle morphogenesis; epithelial to mesenchymal transition; immune response; negative regulation of transforming growth factor beta receptor signaling pathway; cell growth; response to follicle-stimulating hormone stimulus; negative regulation of epithelial cell proliferation
Reference #:  Q03167 (UniProtKB)
Alt. Names/Synonyms: Betaglycan; betaglycan proteoglycan; BGCAN; TGBR3; TGF-beta receptor type 3; TGF-beta receptor type III; TGFBR3; TGFR-3; Transforming growth factor beta receptor III; Transforming growth factor beta receptor type 3; transforming growth factor, beta receptor III
Gene Symbols: TGFBR3
Molecular weight: 93,499 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TGFBR3

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
intracellular localization: T843‑p
molecular association, regulation: T843‑p
receptor internalization, altered: T843‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T84-p GQLQREVtLHLNPIS
0 1 T369-ga MGDEEVHtIPPELRI
0 1 K722 KHPQKLPKCVPPDEA
1 0 S831-p SPPASENsSAAHSIG
1 0 T843-p SIGSTQStPCSSSST
  mouse

 
T86 GQPQREVTLHLNPIA
T370 MRDEEVHTIPPELRI
K720-ub KGSQKLPkCVTPDDA
S830 SPPASENSSAAHSIG
T842 SIGSTQSTPCSSSST
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.