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TGFBR3 (human)

Overview TGFBR3 Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: extracellular space; proteinaceous extracellular matrix; cell surface; integral to plasma membrane; endoplasmic reticulum; external side of plasma membrane Molecular Function: transforming growth factor beta receptor activity; heparin binding; protein binding; glycosaminoglycan binding; transforming growth factor beta binding; punt binding; activin binding; coreceptor activity; SMAD binding; transforming growth factor beta receptor binding; PDZ domain binding Biological Process: transforming growth factor beta receptor complex assembly; heart morphogenesis; blood vessel development; blastocyst development; organ regeneration; cell migration; positive regulation of transforming growth factor beta receptor signaling pathway; protein kinase cascade; negative regulation of cell motility; cardiac muscle cell proliferation; palate development; liver development; activation of NF-kappaB transcription factor; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; regulation of protein binding; response to hypoxia; epithelial to mesenchymal transition; ventricular cardiac muscle morphogenesis; immune response; negative regulation of transforming growth factor beta receptor signaling pathway; cell growth; response to follicle-stimulating hormone stimulus; negative regulation of epithelial cell proliferation Reference #:  Q03167 (UniProtKB) Alt. Names/Synonyms: Betaglycan; betaglycan proteoglycan; BGCAN; TGBR3; TGF-beta receptor type 3; TGF-beta receptor type III; TGFBR3; TGFR-3; Transforming growth factor beta receptor III; Transforming growth factor beta receptor type 3; transforming growth factor, beta receptor III Gene Symbols: TGFBR3 Molecular weight: 93,499 Da Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TGFBR3 4AJV - A=591-757 (mouse)

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	Sites Implicated In
intracellular localization: T843‑p molecular association, regulation: T843‑p receptor internalization, altered: T843‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T369-ga	MGDEEVHtIPPELRI
0	1		K722	KHPQKLPKCVPPDEA
1	0		S831-p	SPPASENsSAAHSIG
1	0		T843-p	SIGSTQStPCSSSST

	mouse
T370	MRDEEVHTIPPELRI
K720-u	KGSQKLPkCVTPDDA
S830	SPPASENSSAAHSIG
T842	SIGSTQSTPCSSSST

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