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Protein Page:
TGFBR3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

TGFBR3 Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; endoplasmic reticulum; integral to plasma membrane; external side of plasma membrane
Molecular Function: transforming growth factor beta receptor activity; heparin binding; protein binding; fibroblast growth factor binding; glycosaminoglycan binding; transforming growth factor beta binding; punt binding; activin binding; coreceptor activity; SMAD binding; transforming growth factor beta receptor binding; PDZ domain binding
Biological Process: transforming growth factor beta receptor complex assembly; heart morphogenesis; blood vessel development; cell migration; organ regeneration; blastocyst development; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of cell motility; cardiac muscle cell proliferation; palate development; liver development; activation of NF-kappaB transcription factor; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; regulation of protein binding; response to hypoxia; ventricular cardiac muscle morphogenesis; epithelial to mesenchymal transition; immune response; cell growth; negative regulation of transforming growth factor beta receptor signaling pathway; response to follicle-stimulating hormone stimulus; negative regulation of epithelial cell proliferation
Reference #:  Q03167 (UniProtKB)
Alt. Names/Synonyms: Betaglycan; betaglycan proteoglycan; BGCAN; TGBR3; TGF-beta receptor type 3; TGF-beta receptor type III; TGFBR3; TGFR-3; Transforming growth factor beta receptor III; Transforming growth factor beta receptor type 3; transforming growth factor, beta receptor III
Gene Symbols: TGFBR3
Molecular weight: 93,499 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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Sites Implicated In
intracellular localization: T843‑p
molecular association, regulation: T843‑p
receptor internalization, altered: T843‑p

Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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