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Protein Page:
CYP2E1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CYP2E1 Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Lipid Metabolism - linoleic acid; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.13.-; Endoplasmic reticulum; EC 1.14.14.1; EC 1.14.13.n7; Mitochondrial; Lipid Metabolism - arachidonic acid
Cellular Component: Golgi membrane; intrinsic to endoplasmic reticulum membrane; endoplasmic reticulum membrane; mitochondrion
Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; enzyme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; oxidoreductase activity; oxygen binding; monooxygenase activity
Biological Process: steroid metabolic process; response to drug; triacylglycerol metabolic process; response to ethanol; response to ozone; xenobiotic metabolic process; monoterpenoid metabolic process; heterocycle metabolic process; response to organic nitrogen; drug metabolic process
Reference #:  P05181 (UniProtKB)
Alt. Names/Synonyms: 4-nitrophenol 2-hydroxylase; CP2E1; CPE1; CYP2E; CYP2E1; CYPIIE1; Cytochrome P450 2E1; cytochrome P450, family 2, subfamily E, polypeptide 1; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; Cytochrome P450-J; flavoprotein-linked monooxygenase; microsomal monooxygenase; P450-J; P450C2E
Gene Symbols: CYP2E1
Molecular weight: 56,849 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
Select Structure to View Below

CYP2E1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K55 LELKNIPKsFtRLAQ
1 0 S56-p ELKNIPKsFtRLAQR
1 0 T58-p KNIPKsFtRLAQRFG
0 1 R59 NIPKsFtRLAQRFGP
1 0 T69-p QRFGPVFtLYVGsQR
1 0 S74-p VFtLYVGsQRMVVMH
0 2 Y83-p RMVVMHGykAVkEAL
0 1 K84 MVVMHGyKAVkEALL
1 2 K84-ub MVVMHGykAVkEALL
1 2 K87-ub MHGykAVkEALLDYK
0 1 K94 kEALLDYKDEFSGRG
0 2 K94 kEALLDYKDEFSGRG
0 1 K94 kEALLDYKDEFSGRG
0 1 R110 LPAFHAHRDRGIIFN
0 2 R110 LPAFHAHRDRGIIFN
0 1 R110 LPAFHAHRDRGIIFN
0 2 R112 AFHAHRDRGIIFNNG
1 0 T121-p IIFNNGPtWKDIRRF
0 1 K123 FNNGPtWKDIRRFsL
0 2 K123 FNNGPtWKDIRRFsL
2 5 S129-p WKDIRRFsLttLRNY
1 2 T131-p DIRRFsLttLRNYGM
1 1 T132-p IRRFsLttLRNYGMG
0 2 K140 LRNYGMGKQGNEsRI
1 0 S145-p MGKQGNEsRIQREAH
0 5 R159 HFLLEALRKTQGQPF
0 2 R159 HFLLEALRKTQGQPF
0 1 R159 HFLLEALRKTQGQPF
0 1 K160 FLLEALRKTQGQPFD
0 1 Q162 LEALRKTQGQPFDPT
0 3 E194 KHFDYNDEKFLRLMY
0 1 E194 KHFDYNDEKFLRLMY
0 1 K195 HFDYNDEKFLRLMYL
0 1 K234 YLPGSHRKVIKNVAE
0 1 K237 GSHRKVIKNVAEVKE
0 1 Y245-p NVAEVKEyVsERVkE
1 1 S247-p AEVKEyVsERVkEHH
0 1 R249 VKEyVsERVkEHHQs
1 0 K251-ub EyVsERVkEHHQsLD
0 2 Q255 ERVkEHHQsLDPNCP
1 1 S256-p RVkEHHQsLDPNCPR
1 2 K275-ub CLLVEMEkEKHSAER
0 1 K324 KYPEIEEKLHEEIDR
1 0 T373-p SNLPHEAtRDtIFRG
1 0 T376-p PHEAtRDtIFRGYLI
1 0 T387-p GYLIPKGtVVVPTLD
0 1 K410 FPDPEKFKPEHFLNE
1 0 K410-ub FPDPEKFkPEHFLNE
0 1 K420 HFLNENGKFkYsDYF
1 0 K420-ub HFLNENGkFkYsDYF
1 1 K422-ub LNENGkFkYsDYFkP
1 0 S424-p ENGkFkYsDYFkPFs
0 1 K428 FkYsDYFKPFstGkR
1 2 K428-ub FkYsDYFkPFstGkR
0 1 K428 FkYsDYFKPFstGkR
1 0 S431-p sDYFkPFstGkRVCA
1 0 T432-p DYFkPFstGkRVCAG
1 1 K434-ub FkPFstGkRVCAGEG
1 0 K461-ub ILQHFNLkPLVDPKD
0 1 K467 LkPLVDPKDIDLSPI
0 2 K467 LkPLVDPKDIDLSPI
0 1 K467 LkPLVDPKDIDLSPI
0 1 K486 GCIPPRYKLCVIPRS
  mouse

 
K55-ub LDLKDIPkSLTkLAK
S56 DLKDIPkSLTkLAKR
T58 KDIPkSLTkLAKRFG
K59-ub DIPkSLTkLAKRFGP
T69 KRFGPVFTLHLGQRR
Q74 VFTLHLGQRRIVVLH
Y83 RIVVLHGYkAVkEVL
K84-ac IVVLHGYkAVkEVLL
K84-ub IVVLHGYkAVkEVLL
K87-ub LHGYkAVkEVLLNHk
K94-ac kEVLLNHkNEFSGRG
K94-ub kEVLLNHkNEFSGRG
K94-sc kEVLLNHkNEFSGRG
K110-ac IPVFQEYkNkGIIFN
K110-ub IPVFQEYkNkGIIFN
K110-sc IPVFQEYkNkGIIFN
K112-ub VFQEYkNkGIIFNNG
T121 IIFNNGPTWkDVRRF
K123-ac FNNGPTWkDVRRFsL
K123-ub FNNGPTWkDVRRFsL
S129-p WkDVRRFsLSILRDW
S131 DVRRFsLSILRDWGM
I132 VRRFsLSILRDWGMG
K140-ub LRDWGMGkQGNEARI
A145 MGkQGNEARIQREAH
K159-ac HFLVEELkkTkGQPF
K159-ub HFLVEELkkTkGQPF
K159-sc HFLVEELkkTkGQPF
K160-ub FLVEELkkTkGQPFD
K162-ub VEELkkTkGQPFDPT
K194-ac KRFDYDDkkCLELMS
K194-ub KRFDYDDkkCLELMS
K195-ac RFDYDDkkCLELMSL
K234-ub YLPGSHRkVMkNVSE
K237-ub GSHRkVMkNVSEIRQ
Y245 NVSEIRQYTLGkAKE
T246 VSEIRQYTLGkAKEH
K249-ub IRQYTLGkAKEHLkS
K251 QYTLGkAKEHLkSLD
K255-ub GkAKEHLkSLDINCP
S256 kAKEHLkSLDINCPR
K275-ub CLLIEMEkEKHSQEP
K324-ub KYPEIEEkLHEEIDR
T373 SNLPHEATRDTVFRG
T376 PHEATRDTVFRGYVI
T387 GYVIPKGTVVIPTLD
K410-ac FPDPETFkPEHFLNE
K410 FPDPETFKPEHFLNE
K420-ac HFLNENGkFkYSDYF
K420 HFLNENGKFkYSDYF
K422-ub LNENGkFkYSDYFkA
S424 ENGkFkYSDYFkAFS
K428-ac FkYSDYFkAFSAGkR
K428-ub FkYSDYFkAFSAGkR
K428-sc FkYSDYFkAFSAGkR
S431 SDYFkAFSAGkRVCV
A432 DYFkAFSAGkRVCVG
K434-ub FkAFSAGkRVCVGEG
K461 ILQHFNLKSLVDPkD
K467-ac LKSLVDPkDIDLSPV
K467-ub LKSLVDPkDIDLSPV
K467-sc LKSLVDPkDIDLSPV
K486-ub GSIPREFkLCVIPRS
  rat

 
K55 LDLKDIPKSFTKLAK
S56 DLKDIPKSFTKLAKR
T58 KDIPKSFTKLAKRFG
K59 DIPKSFTKLAKRFGP
T69 KRFGPVFTLHLGSRR
S74 VFTLHLGSRRIVVLH
Y83 RIVVLHGYKAVKEVL
K84 IVVLHGYKAVKEVLL
K84 IVVLHGYKAVKEVLL
K87 LHGYKAVKEVLLNHK
K94 KEVLLNHKNEFSGRG
K94 KEVLLNHKNEFSGRG
K94 KEVLLNHKNEFSGRG
K110 IPVFQEYKNKGIIFN
K110 IPVFQEYKNKGIIFN
K110 IPVFQEYKNKGIIFN
K112 VFQEYKNKGIIFNNG
T121 IIFNNGPTWKDVRRF
K123 FNNGPTWKDVRRFsL
K123 FNNGPTWKDVRRFsL
S129-p WKDVRRFsLSILRDW
S131 DVRRFsLSILRDWGM
I132 VRRFsLSILRDWGMG
K140 LRDWGMGKQGNEARI
A145 MGKQGNEARIQREAQ
K159 QFLVEELKKTKGQPF
K159 QFLVEELKKTKGQPF
K159 QFLVEELKKTKGQPF
K160 FLVEELKKTKGQPFD
K162 VEELKKTKGQPFDPT
K194 KRFDYNDKKCLRLMS
K194 KRFDYNDKKCLRLMS
K195 RFDYNDKKCLRLMSL
K234 YLPGSHRKIMKNVSE
K237 GSHRKIMKNVSEIKQ
Y245 NVSEIKQYTLEKAKE
T246 VSEIKQYTLEKAKEH
K249 IKQYTLEKAKEHLQS
K251 QYTLEKAKEHLQSLD
Q255 EKAKEHLQSLDINCA
S256 KAKEHLQSLDINCAR
K275 CLLIEMEKEKHSQEP
K324 KYPEIEEKLHEEIDR
T373 SNLPHEATRDTVFQG
T376 PHEATRDTVFQGYVI
T387 GYVIPKGTVVIPTLD
K410 FPDPEKFKPEHFLNE
K410 FPDPEKFKPEHFLNE
K420 HFLNENGKFKYSDYF
K420 HFLNENGKFKYSDYF
K422 LNENGKFKYSDYFKA
S424 ENGKFKYSDYFKAFS
K428 FKYSDYFKAFSAGKR
K428 FKYSDYFKAFSAGKR
K428 FKYSDYFKAFSAGKR
S431 SDYFKAFSAGKRVCV
A432 DYFKAFSAGKRVCVG
K434 FKAFSAGKRVCVGEG
K461 ILQHFNLKSLVDPKD
K467 LKSLVDPKDIDLSPV
K467 LKSLVDPKDIDLSPV
K467 LKSLVDPKDIDLSPV
K486 GSIPPQFKLCVIPRS
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