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Protein Page:
PKG1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKG1 an AGC kinase of the PKG family. Type I cGMP-dependent protein kinase; relaxes vascular smooth muscle and inhibits platelet aggregation. Binding of cGMP results in enzyme activation. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.12; Protein kinase, AGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; PKG family
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: Golgi apparatus; cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; calcium channel regulator activity; cGMP-dependent protein kinase activity; cGMP binding; ATP binding
Biological Process: regulation of GTPase activity; forebrain development; dendrite development; neuron migration; actin cytoskeleton organization and biogenesis; signal transduction; blood coagulation; protein amino acid phosphorylation
Reference #:  Q13976 (UniProtKB)
Alt. Names/Synonyms: cGK 1; cGK1; cGKI; cGKI-alpha; cGKI-BETA; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; DKFZp686K042; FLJ36117; KGP1; MGC71944; PGK; PKG; PRKG1; PRKG1B; PRKGR1A; PRKGR1B; protein kinase, cGMP-dependent, regulatory, type I, beta; protein kinase, cGMP-dependent, type I
Gene Symbols: PRKG1
Molecular weight: 76,364 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PKG1

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
transcription, altered: T517‑p
enzymatic activity, induced: T59‑p, S65‑p, T517‑p
phosphorylation: T517‑p
ubiquitination: S65‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 S27-p KELEKRLsEKEEEIQ
1 0 S45 RKLHKCQSVLPVPsT
1 0 - gap
3 0 V49 KCQSVLPVPsTHIGP
3 0 S51-p QSVLPVPsTHIGPRT
4 1 T59-p THIGPRTtRAQGIsA
5 0 S65-p TtRAQGIsAEPQTYR
2 0 S73 AEPQTYRSFHDLRQA
3 0 T85-p RQAFRKFtKSERSKD
0 1 Y212-p GLIKHTEyMEFLKsV
0 1 S218-p EyMEFLKsVPTFQSL
0 1 S231-p SLPEEILsKLADVLE
0 1 Y247-p THYENGEyIIRQGAR
0 2 S273-p VNVTREDsPSEDPVF
0 1 Y433-p RTFKDSKyLyMLMEA
0 1 Y435-p FKDSKyLyMLMEACL
0 2 R483 HSKGIIYRDLKPENL
0 1 Y497-p LILDHRGyAKLVDFG
0 1 K513 AKKIGFGKKtWtFCG
0 5 T515-p KIGFGKKtWtFCGTP
1 14 T517-p GFGKKtWtFCGTPEY
0 1 T521 KtWtFCGTPEYVAPE
0 1 K582 DMIEFPKKIAKNAAN
0 3 K607-ac SERLGNLkNGVKDIQ
0 3 K615-ac NGVKDIQkHkWFEGF
0 3 K617-ac VKDIQkHkWFEGFNW
0 1 S647 VASPTDTSNFDSFPE
  PKG1 iso2  
Y10-p GTLRDLQyALQEKIE
- gap
S52 NELDKYRSVIRPATQ
T58 RSVIRPATQQAQKQs
S65-p TQQAQKQsASTLQGE
S67 QAQKQsASTLQGEPR
T75-p TLQGEPRtKRQAIsA
S81-p RtKRQAIsAEPTAFD
I89 AEPTAFDIQDLSHVT
P101 HVTLPFYPKSPQSKD
Y228 GLIKHTEYMEFLKSV
S234 EYMEFLKSVPTFQSL
S247 SLPEEILSKLADVLE
Y263 THYENGEYIIRQGAR
S289 VNVTREDSPSEDPVF
Y449 RTFKDSKYLYMLMEA
Y451 FKDSKYLYMLMEACL
R499 HSKGIIYRDLKPENL
Y513 LILDHRGYAKLVDFG
K529 AKKIGFGKKTWTFCG
T531 KIGFGKKTWTFCGTP
T533 GFGKKTWTFCGTPEY
T537 KTWTFCGTPEYVAPE
K598 DMIEFPKKIAKNAAN
K623 SERLGNLKNGVKDIQ
K631 NGVKDIQKHKWFEGF
K633 VKDIQKHKWFEGFNW
S663 VASPTDTSNFDSFPE
  mouse

► Hide Isoforms
 
- gap
S27 KELEKRLSEKEEEIQ
S45 RKLHKCQSVLPVPsT
- gap
V49 KCQSVLPVPsTHIGP
S51-p QSVLPVPsTHIGPRT
T59-p THIGPRTtRAQGISA
S65 TtRAQGISAEPQTYR
S73-p AEPQTYRsFHDLRQA
T85-p RQAFRKFtKSERSKD
Y212 GLIKHTEYMEFLKSV
S218 EYMEFLKSVPTFQSL
S231 SLPDEILSKLADVLE
Y247 THYENGEYIIRQGAR
S273-p VNVTREDsPSEDPVF
Y433 RTFKDSKYLYMLMEA
Y435 FKDSKYLYMLMEACL
R483-m1 HSKGIIYrDLKPENL
Y497 LILDHRGYAKLVDFG
K513-ac AKKIGFGkKtWtFCG
T515-p KIGFGkKtWtFCGtP
T517-p GFGkKtWtFCGtPEY
T521-p KtWtFCGtPEYVAPE
K582-ac DMIEFPKkIAKNAAN
K607 SERLGNLKNGVKDIQ
K615 NGVKDIQKHKWFEGF
K617 VKDIQKHKWFEGFNW
S647-p VASPTDTsNFDSFPE
  PKG1 iso2  
Y10 GTLRDLQYALQEKIE
- gap
S52 NELDKYRSVIRPAtQ
T58-p RSVIRPAtQQAQKQs
S65-p tQQAQKQsASTLQGE
S67 QAQKQsASTLQGEPR
T75 TLQGEPRTKRQAIsA
S81-p RTKRQAIsAEPTAFD
I89 AEPTAFDIQDLSHVT
P101 HVTLPFYPKSPQSKD
Y228 GLIKHTEYMEFLKSV
S234 EYMEFLKSVPTFQSL
S247 SLPDEILSKLADVLE
Y263 THYENGEYIIRQGAR
S289 VNVTREDSPSEDPVF
Y449 RTFKDSKYLYMLMEA
Y451 FKDSKYLYMLMEACL
R499 HSKGIIYRDLKPENL
Y513 LILDHRGYAKLVDFG
K529 AKKIGFGKKtWtFCG
T531-p KIGFGKKtWtFCGtP
T533-p GFGKKtWtFCGtPEY
T537-p KtWtFCGtPEYVAPE
K598 DMIEFPKKIAKNAAN
K623 SERLGNLKNGVKDIQ
K631 NGVKDIQKHKWFEGF
K633 VKDIQKHKWFEGFNW
S663 VASPTDTSNFDSFPE
  rat

 
- gap
S27 KELEKRLSEKEEEIQ
S45 RKLHKCQSVLPVPST
- gap
V49 KCQSVLPVPSTHIGP
S51 QSVLPVPSTHIGPRT
T59 THIGPRTTRAQGISA
S65 TTRAQGISAEPQTYR
S73 AEPQTYRSFHDLRQA
T85 RQAFRKFTKSERSKD
Y212 GLIKHTEYMEFLKSV
S218 EYMEFLKSVPTFQSL
S231 SLPDEILSKLADVLE
Y247 THYENGEYIIRQGAR
S273 VSVTREDSPSEDPVF
Y433 RTFKDSKYLYMLMEA
Y435 FKDSKYLYMLMEACL
R483 HSKGIIYRDLKPENL
Y497 LILDHRGYAELVDFG
K513 AKKIGFGKKTWtFCG
T515 KIGFGKKTWtFCGTP
T517-p GFGKKTWtFCGTPEY
T521 KTWtFCGTPEYVAPE
K582 DMIEFPKKIAKSAAN
K607 SERLGNLKNGVKDIQ
K615 NGVKDIQKHKWFEGF
K617 VKDIQKHKWFEGFNW
S647 VASPTDTSNFDSFPE
  cow

 
- gap
S27-p KELEKRLsEKEEEIQ
S45-p RKLHKCQsVLPVPsT
- gap
V49 KCQsVLPVPsTHIGP
S51-p QsVLPVPsTHIGPRT
T59-p THIGPRTtRAQGIsA
S65-p TtRAQGIsAEPQTYR
S73-p AEPQTYRsFHDLRQA
T85-p RQAFRKFtKSERSKD
Y212 GLIKHTEYMEFLKSV
S218 EYMEFLKSVPTFQSL
S231 SLPEEILSKLADVLE
Y247 THYENGEYIIRQGAR
S273 VNVTREDSPNEDPVF
Y433 RTFKDSKYLYMLMEA
Y435 FKDSKYLYMLMEACL
R483 HSKGIIYRDLKPENL
Y497 LILDHRGYAKLVDFG
K513 AKKIGFGKKTWtFCG
T515 KIGFGKKTWtFCGTP
T517-p GFGKKTWtFCGTPEY
T521 KTWtFCGTPEYVAPE
K582 DMIEFPKKIAKNAAN
K607 SERLGNLKNGVKDIQ
K615 NGVKDIQKHKWFEGF
K617 VKDIQKHKWFEGFNW
S647 VASPTDTSNFDSFPE
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