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Protein Page:
SKP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SKP2 an F-box protein of the SCF (SKP1-CUL1-F- box protein) E3 ubiquitin ligase system. The F-box component of the SCF complex is responsible for recognizing different substrates for ubiquitination. The SCF E3 complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Cellular Component: nucleoplasm; cytoplasm; nucleolus; SCF ubiquitin ligase complex; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; ubiquitin-protein ligase activity
Biological Process: cell proliferation; protein polyubiquitination; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of cell cycle; positive regulation of smooth muscle cell proliferation; positive regulation of estrogen receptor signaling pathway; mitotic cell cycle; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle
Reference #:  Q13309 (UniProtKB)
Alt. Names/Synonyms: CDK2/cyclin A-associated protein p45; cyclin A/CDK2-associated protein p45; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; FBL1; FBXL1; FLB1; MGC1366; p45skp2; S-phase kinase-associated protein 2; S-phase kinase-associated protein 2 (p45); SKP2
Gene Symbols: SKP2
Molecular weight: 47,761 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SKP2

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S64‑p, S72‑p, T417‑p
activity, induced: S64‑p, T417‑p
phosphorylation: S64‑p, S72‑p
protein stabilization: S64‑p, S72‑p, T417‑p
ubiquitination: S64‑p, T417‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S48-p LEKEEPDsENIPQEL
0 1 S57-p NIPQELLsNLGHPEs
3 13 S64-p sNLGHPEsPPRkRLk
2 0 K68-ac HPEsPPRkRLksKGs
2 0 K71-ac sPPRkRLksKGsDKD
3 8 S72-p PPRkRLksKGsDKDF
1 4 S75-p kRLksKGsDKDFVIV
0 3 K145-ub QTLDLTGkNLHPDVT
0 6 S179-p QPLAEHFsPFRVQHM
0 1 S212-p CSKLQNLsLEGLRLS
0 3 N224 RLSDPIVNTLAkNSN
0 1 K228-ub PIVNTLAkNSNLVRL
0 1 S303-p NLQKSDLsTLVRRCP
1 0 T417-p WGIKCRLtLQKPSCL
  mouse

 
S48 LEKEEVDSENIPHGL
S57 NIPHGLLSNLGHPQS
S64 SNLGHPQSPPRkRVk
K68-ac HPQSPPRkRVkGKGS
K71-ac SPPRkRVkGKGSDKD
G72 PPRkRVkGKGSDKDF
S75 kRVkGKGSDKDFVII
K145 QSLDLAGKNLHPDVT
S179 QPLGESFSSFRVQHM
S212 CSKLQNLSLEGLQLS
K224-ub QLSDPIVkTLAQNEN
Q228 PIVkTLAQNENLVRL
C303 NLQKTDLCTIIKRCP
T417 WGIKCRLTLQKPSCL
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