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HP1 alpha (human)

Overview HP1 alpha Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Interacts with SUV420H1 and SUV420H2. Interacts with HP1BP3. Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys- 9'. Interacts with BAHD1, MIS12 and DSN1. Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete for interaction with CBX5. Interacts with INCENP and TRIM24. Interacts with JC virus agnoprotein; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope. Interacts with CHAMP1. Interacts with ASXL1. Note: This description may include information from UniProtKB. Protein type: Transcription, coactivator/corepressor Cellular Component: kinetochore; nucleoplasm; histone methyltransferase complex; PML body; transcriptional repressor complex; cytoplasm; histone deacetylase complex; nucleolus; nuclear envelope; nuclear heterochromatin; nucleus; chromocenter Molecular Function: protein binding, bridging; protein binding; enzyme binding; histone deacetylase binding; chromatin binding; methylated histone residue binding Biological Process: virus-host interaction; blood coagulation; negative regulation of transcription, DNA-dependent Reference #:  P45973 (UniProtKB) Alt. Names/Synonyms: Antigen p25; CBX5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox protein homolog 5; Heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HP1; HP1 alpha; HP1-ALPHA; HP1A; HP1Hs alpha Gene Symbols: CBX5 Molecular weight: 22,225 Da Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states CST Pathways:  Histone Methylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HP1 alpha 3FDT - A=18-75 (human) 3I3C - A/D/C/B=110-173 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	6		T8-p	MGKKTKRtADssssE
1	18		S11-p	KTKRtADssssEDEE
1	16		S12-p	TKRtADssssEDEEE
1	21		S13-p	KRtADssssEDEEEy
1	22		S14-p	RtADssssEDEEEyV
0	3		Y20-p	ssEDEEEyVVEKVLD
0	1		K32-m1	VLDRRVVkGQVEYLL
0	2		K32-u	VLDRRVVkGQVEYLL
0	1		K40-a	GQVEYLLkWKGFSEE
0	1		K40-m1	GQVEYLLkWKGFSEE
0	1		K40-u	GQVEYLLkWKGFSEE
0	1		K55-a	HNTWEPEkNLDCPEL
0	2		K55-u	HNTWEPEkNLDCPEL
0	1		K68	ELISEFMKKYKKMKE
0	1		K91-a	KSESNKRksNFsNsA
0	1		K91-m1	KSESNKRksNFsNsA
0	8		K91-u	KSESNKRksNFsNsA
1	35		S92-p	SESNKRksNFsNsAD
1	46		N93	ESNKRksNFsNsADD
1	7		S95-p	NKRksNFsNsADDIk
1	11		S97-p	RksNFsNsADDIkSk
0	7		K102-u	sNsADDIkSkKkREQ
0	2		K104-u	sADDIkSkKkREQsN
0	1		K106-a	DDIkSkKkREQsNDI
0	2		S110-p	SkKkREQsNDIARGF
0	23		K125-u	ERGLEPEkIIGAtDs
0	1		T130-p	PEkIIGAtDsCGDLM
0	2		S132-p	kIIGAtDsCGDLMFL
0	1		K143-a	LMFLMKWkDTDEADL
0	1		K143-m1	LMFLMKWkDTDEADL
0	2		K143-u	LMFLMKWkDTDEADL
0	1		K154-m2	EADLVLAkEANVkCP
0	41		K154-u	EADLVLAkEANVkCP
0	7		K159-u	LAkEANVkCPQIVIA
0	3		Y177-p	ERLTWHAyPEDAENk
0	9		K184-u	yPEDAENkEKETAKS

	mouse
T8-p	MGKKTKRtADssssE
S11-p	KTKRtADssssEDEE
S12-p	TKRtADssssEDEEE
S13-p	KRtADssssEDEEEy
S14-p	RtADssssEDEEEyV
Y20-p	ssEDEEEyVVEKVLD
K32	VLDRRMVKGQVEYLL
K32-u	VLDRRMVkGQVEYLL
K40	GQVEYLLKWKGFSEE
K40	GQVEYLLKWKGFSEE
K40	GQVEYLLKWKGFSEE
K55	HNTWEPEKNLDCPEL
K55	HNTWEPEKNLDCPEL
K68-u	ELISEFMkKYKKMKE
K91	KSEGNKRKssFsNsA
K91	KSEGNKRKssFsNsA
K91-u	KSEGNKRkssFsNsA
S92-p	SEGNKRkssFsNsAD
S93-p	EGNKRkssFsNsADD
S95-p	NKRkssFsNsADDIk
S97-p	RkssFsNsADDIkSK
K102-u	sNsADDIkSKKKREQ
K104	sADDIkSKKKREQSN
K106	DDIkSKKKREQSNDI
S110	SKKKREQSNDIARGF
K125-u	ERGLEPEkIIGATDS
T130	PEkIIGATDSCGDLM
S132	kIIGATDSCGDLMFL
K143	LMFLMKWKDTDEADL
K143	LMFLMKWKDTDEADL
K143-u	LMFLMKWkDTDEADL
K154	EADLVLAKEANVkCP
K154-u	EADLVLAkEANVkCP
K159-u	LAkEANVkCPQIVIA
Y177	ERLTWHAYPEDAENk
K184-u	YPEDAENkEKESAKS

	rat
T8	MGKKTKRTADSSSSE
S11	KTKRTADSSSSEDEE
S12	TKRTADSSSSEDEEE
S13	KRTADSSSSEDEEEY
S14	RTADSSSSEDEEEYV
Y20	SSEDEEEYVVEKVLD
K32	VLDRRMVKGQVEYLL
K32	VLDRRMVKGQVEYLL
K40	GQVEYLLKWKGFSEE
K40	GQVEYLLKWKGFSEE
K40	GQVEYLLKWKGFSEE
K55	HNTWEPEKNLDCPEL
K55	HNTWEPEKNLDCPEL
K68	ELISEFMKKYKKMKE
K91	KSEGNKRKSsFSNSA
K91	KSEGNKRKSsFSNSA
K91	KSEGNKRKSsFSNSA
S92	SEGNKRKSsFSNSAD
S93-p	EGNKRKSsFSNSADD
S95	NKRKSsFSNSADDIK
S97	RKSsFSNSADDIKSK
K102	SNSADDIKSKKKREQ
K104	SADDIKSKKKREQSN
K106	DDIKSKKKREQSNDI
S110	SKKKREQSNDIARGF
K125	ERGLEPEKIIGATDS
T130	PEKIIGATDSCGDLM
S132	KIIGATDSCGDLMFL
K143	LMFLMKWKDTDEADL
K143	LMFLMKWKDTDEADL
K143	LMFLMKWKDTDEADL
K154	EADLVLAKEANVKCP
K154	EADLVLAKEANVKCP
K159	LAKEANVKCPQIVIA
Y177	ERLTWHAYPEDAENK
K184	YPEDAENKEKESAKS

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