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STXBP4 (human)

Overview STXBP4 Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose. Interacts with STX4A. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Vesicle protein Cellular Component: intermediate filament cytoskeleton; cytoplasm; nucleolus; nucleus Molecular Function: calcium ion binding Biological Process: insulin receptor signaling pathway; glucose transport; protein targeting Reference #:  Q6ZWJ1 (UniProtKB) Alt. Names/Synonyms: FLJ16496; MGC149829; MGC50337; STX4-interacting protein; STXB4; STXBP4; Synip; syntaxin 4 interacting protein; Syntaxin 4-interacting protein; syntaxin binding protein 4; Syntaxin-binding protein 4 Gene Symbols: STXBP4 Molecular weight: 61,662 Da Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below STXBP4 2YSG - A=498-530 (human) 1WI4 - A=10-107 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		T5	___MNKNTsTVVsPS
0	2		S6-p	__MNKNTsTVVsPSL
0	3		S10-p	KNTsTVVsPSLLEkD
0	1		P11	NTsTVVsPSLLEkDP
0	1		S12	TsTVVsPSLLEkDPA
0	1		K16-u	VsPSLLEkDPAFQMI
0	1		K27-u	FQMITIAkETGLGLK
3	3		S99-p	GAKLRLEsAWEIAFI
0	3		T157-p	KTSSTPKtNNDILSS
0	1		S208	YGLQEKISLNPSVRF
0	1		K385-u	EAKITELkAQLADYS
0	1		K396-u	ADYSDQNkESVQDLK
0	1		S445-p	QEVFSDNstPLSNLS
0	4		T446-p	EVFSDNstPLSNLSE
0	1		S460-p	ERRAVLAsQTsLtPL
0	1		S463-p	AVLAsQTsLtPLGRN
0	1		T465-p	LAsQTsLtPLGRNGR

	STXBP4 iso4
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S24	KLSTRLESAWEIAFI
T82	KTSSTPKTNNDILSS
S133	YGLQEKISLNPSVRF
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	mouse
T5-p	___MSDGtASARSss
A6	__MSDGtASARSssP
S10	DGtASARSssPLDRD
S11-p	GtASARSssPLDRDP
S12-p	tASARSssPLDRDPA
R16	RSssPLDRDPAFRVI
K27	FRVITVTKETGLGLK
S99-p	RAKLRSEsPWEIAFI
T156	KTSSTPQTQDSTFPS
S212-p	SGPQGKIsLNPSVRL
K389	EAEVSELKAQLADYS
K400	ADYSDQNKESVQDLR
S449	QEVLLDSSAPLSTLS
A450	EVLLDSSAPLSTLSE
S464	ERRAVLASQTSLPLL
S467	AVLASQTSLPLLARN
P469	LASQTSLPLLARNGR

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