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PAX2 (human)

Overview PAX2 Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS. Interacts with ELGN3; the interaction targets PAX2 for destruction. Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Cellular Component: protein complex; microtubule organizing center; nucleus Molecular Function: protein binding; DNA binding; superoxide-generating NADPH oxidase activity Biological Process: negative regulation of cytolysis; transcription from RNA polymerase II promoter; optic nerve structural organization; positive regulation of transcription, DNA-dependent; cell fate determination; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; pronephros development; glial cell differentiation; vestibulocochlear nerve formation; visual perception; brain morphogenesis; negative regulation of programmed cell death; protein kinase B signaling cascade; mesonephros development; inner ear morphogenesis; camera-type eye development; transcription, DNA-dependent; optic cup morphogenesis involved in camera-type eye development; stem cell differentiation; optic nerve morphogenesis; axonogenesis; optic nerve development; ureteric bud branching; neural tube closure; mesodermal cell fate specification; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; urogenital system development; positive regulation of epithelial cell proliferation; negative regulation of apoptosis Reference #:  Q02962 (UniProtKB) Alt. Names/Synonyms: paired box 2; paired box homeotic gene 2; Paired box protein Pax-2; PAX2 Gene Symbols: PAX2 Molecular weight: 44,706 Da Basal Isoelectric point: 7.25  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PAX2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 120330 167409  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		Y72-p	VSKILGRyyETGSIK
0	1		Y73-p	SKILGRyyETGSIKP
0	1		T226-p	GGLHLVWtLRDVSEG
0	1		T255	RKHLRADTFTQQQLE

	PAX2 iso2
Y72	VSKILGRYYETGSIK
Y73	SKILGRYYETGSIKP
T226	GGLHLVWTLRDVSEG
T255	RKHLRADTFTQQQLE

	mouse
Y71-p	VSKILGRyYETGSIK
Y72	SKILGRyYETGSIKP
T225	GGLHLVWTLRDVSEG
T254	RKHLRADTFTQQQLE

	rat
Y71	VSKILGRYYETGSIK
Y72	SKILGRYYETGSIKP
T225	GGLHLVWTLRDVSEG
T254-p	RKHLRADtFTQQQLE

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