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Protein Page:
PAX2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PAX2 Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS. Interacts with ELGN3; the interaction targets PAX2 for destruction. Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: protein complex; lysosome; microtubule organizing center; nucleus
Molecular Function: protein binding; DNA binding; superoxide-generating NADPH oxidase activity
Biological Process: transcription from RNA polymerase II promoter; negative regulation of cytolysis; optic nerve structural organization; positive regulation of transcription, DNA-dependent; cell fate determination; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; pronephros development; glial cell differentiation; visual perception; vestibulocochlear nerve formation; pancreas development; protein kinase B signaling cascade; brain morphogenesis; negative regulation of programmed cell death; mesonephros development; aging; response to nutrient levels; inner ear morphogenesis; camera-type eye development; transcription, DNA-dependent; optic cup morphogenesis involved in camera-type eye development; stem cell differentiation; optic nerve morphogenesis; axonogenesis; ureteric bud branching; optic nerve development; neural tube closure; mesodermal cell fate specification; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; urogenital system development; positive regulation of epithelial cell proliferation; negative regulation of apoptosis
Reference #:  Q02962 (UniProtKB)
Alt. Names/Synonyms: paired box 2; paired box homeotic gene 2; Paired box protein Pax-2; PAX2
Gene Symbols: PAX2
Molecular weight: 44,706 Da
Basal Isoelectric point: 7.25  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PAX2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y72 VSKILGRYYETGSIK
0 1 K98-ac ATPKVVDkIAEYKRQ
0 1 T226-p GGLHLVWtLRDVSEG
0 1 T255 RKHLRADTFTQQQLE
  PAX2 iso2  
Y72 VSKILGRYYETGSIK
K98 ATPKVVDKIAEYKRQ
T226 GGLHLVWTLRDVSEG
T255 RKHLRADTFTQQQLE
  mouse

 
Y71-p VSKILGRyYETGSIK
K97 ATPKVVDKIAEYKRQ
T225 GGLHLVWTLRDVSEG
T254 RKHLRADTFTQQQLE
  rat

 
Y71 VSKILGRYYETGSIK
K97-ac ATPKVVDkIAEYKRQ
T225 GGLHLVWTLRDVSEG
T254-p RKHLRADtFTQQQLE
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