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Protein Page:
PAX2 (human)

Overview
PAX2 Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS. Interacts with ELGN3; the interaction targets PAX2 for destruction. Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: protein complex; lysosome; microtubule organizing center; nucleus
Molecular Function: protein binding; DNA binding; superoxide-generating NADPH oxidase activity
Biological Process: negative regulation of cytolysis; transcription from RNA polymerase II promoter; optic nerve structural organization; positive regulation of transcription, DNA-dependent; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; cell fate determination; pronephros development; glial cell differentiation; visual perception; vestibulocochlear nerve formation; pancreas development; brain morphogenesis; protein kinase B signaling cascade; negative regulation of programmed cell death; mesonephros development; aging; response to nutrient levels; inner ear morphogenesis; camera-type eye development; transcription, DNA-dependent; optic cup morphogenesis involved in camera-type eye development; optic nerve morphogenesis; stem cell differentiation; axonogenesis; optic nerve development; ureteric bud branching; neural tube closure; mesodermal cell fate specification; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; urogenital system development; negative regulation of apoptosis
Reference #:  Q02962 (UniProtKB)
Alt. Names/Synonyms: paired box 2; paired box homeotic gene 2; Paired box protein Pax-2; PAX2
Gene Symbols: PAX2
Molecular weight: 44,706 Da
Basal Isoelectric point: 7.25  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PAX2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T226-p GGLHLVWtLRDVSEG
0 1 T255 RKHLRADTFTQQQLE
  PAX2 iso2  
T226 GGLHLVWTLRDVSEG
T255 RKHLRADTFTQQQLE
  mouse

 
T225 GGLHLVWTLRDVSEG
T254 RKHLRADTFTQQQLE
  rat

 
T225 GGLHLVWTLRDVSEG
T254-p RKHLRADtFTQQQLE
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