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Protein Page:
dynactin 1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
dynactin 1 Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles. Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B); also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors. Defects in DCTN1 are the cause of Perry syndrome (PERRYS); also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally. Belongs to the dynactin 150 kDa subunit family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor protein; Microtubule binding protein
Cellular Component: kinetochore; dynein complex; spindle pole; microtubule; centrosome; dynactin complex; membrane; leading edge; cytoplasm; cytosol
Molecular Function: dynein binding; protein binding; motor activity
Biological Process: cell death; mitosis; nervous system development; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; antigen processing and presentation of exogenous peptide antigen via MHC class II; mitotic cell cycle; G2/M transition of mitotic cell cycle
Reference #:  Q14203 (UniProtKB)
Alt. Names/Synonyms: 150 kDa dynein-associated polypeptide; DAP-150; DCTN1; DP-150; dynactin 1; dynactin 1 (p150, glued homolog, Drosophila); Dynactin subunit 1; HMN7B; p135; p150, Glued homolog; p150-glued
Gene Symbols: DCTN1
Molecular weight: 141,695 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
Select Structure to View Below

dynactin 1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S179‑p
cytoskeletal reorganization: S19‑p
intracellular localization: S19‑p, S179‑p
molecular association, regulation: S179‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
2 0 S19-p TPSGSRMsAEAsARP
0 1 S23-p SRMsAEAsARPLRVG
0 1 S31-p ARPLRVGsRVEVIGK
0 1 T104 FEDGADTTsPEtPDs
0 6 S105-p EDGADTTsPEtPDsS
0 12 T108-p ADTTsPEtPDsSASK
0 1 S111-p TsPEtPDsSASKVLK
0 1 T141 LKPKKAPTARKTTTR
0 1 T158-p KPTRPAStGVAGAsS
0 1 S164-p StGVAGAsSSLGPSG
0 1 S172-p SSLGPSGsASAGELs
2 0 S179-p sASAGELsSSEPSTP
0 1 S203-p IPTPVLTsPGAVPPL
1 1 S212-p GAVPPLPsPsKEEEG
0 1 S214-p VPPLPsPsKEEEGLR
0 1 K230-ac QVRDLEEkLEtLRLK
0 1 T233-p DLEEkLEtLRLKRAE
0 2 K290-ac AKEALEAkERYMEEM
0 1 T336-p KERVDELtTDLEILK
0 1 K501-ub ARVREAQkRVEAAQE
0 1 Y513-p AQETVADyQQTIKKY
0 2 S541-p LTNQQEAsVERQQQP
0 1 K556 PPETFDFKIKFAETK
0 1 S687-p DVYKKVGsLYPEMsA
0 1 S693-p GsLYPEMsAHERSLD
0 1 K722 VNVEPLTKAIKYYQH
0 1 S919 YDAERPPSKPPPVEL
0 1 S982-p LLEKKLDsAAKDADE
0 1 T996-p ERIEKVQtRLEEtQA
0 1 T1001-p VQtRLEEtQALLRKK
0 1 K1007 EtQALLRKKEKEFEE
0 3 S1041-p KQRLNSQsKRTIEGL
0 1 K1120-ub ILKGAQMkASLASLP
0 2 Y1149-p ELPAGALyRKtsQLL
0 2 T1152-p AGALyRKtsQLLETL
0 5 S1153-p GALyRKtsQLLETLN
0 1 T1158 KtsQLLETLNQLSTH
0 1 K1179-ub TRTSPAAkSPsAQLM
0 1 S1182-p SPAAkSPsAQLMEQV
0 3 K1193-ub MEQVAQLkSLSDTVE
0 2 K1235-ub SSAFLRAkEEQQDDT
0 2 Y1244-p EQQDDTVyMGKVTFS
0 1 S1251 yMGKVTFSCAAGFGQ
0 1 T1265 QRHRLVLTQEQLHQL
  dynactin 1 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T7 _MMRQAPTARKTTTR
T24 KPTRPASTGVAGASS
S30 STGVAGASSSLGPSG
S38 SSLGPSGSASAGELS
S45 SASAGELSSSEPSTP
S69 IPTPVLTSPGAVPPL
S78 GAVPPLPSPSKEEEG
S80 VPPLPSPSKEEEGLR
K96 QVRDLEEKLETLRLK
T99 DLEEKLETLRLKRAE
K156 AKEALEAKERYMEEM
T202 KERVDELTTDLEILK
K367 ARVREAQKRVEAAQE
Y379 AQETVADYQQTIKKY
S407 LTNQQEASVERQQQP
K422 PPETFDFKIKFAETK
S553 DVYKKVGSLYPEMSA
S559 GSLYPEMSAHERSLD
K588 VNVEPLTKAIKYYQH
S785 YDAERPPSKPPPVEL
S848 LLEKKLDSAAKDADE
T862 ERIEKVQTRLEETQA
T867 VQTRLEETQALLRKK
K873 ETQALLRKKEKEFEE
S907 KQRLNSQSKRTIEGL
K986 ILKGAQMKASLASLP
Y1015 ELPAGALYRKTSQLL
T1018 AGALYRKTSQLLETL
S1019 GALYRKTSQLLETLN
T1024 KTSQLLETLNQLSTH
K1045 TRTSPAAKSPSAQLM
S1048 SPAAKSPSAQLMEQV
K1059 MEQVAQLKSLSDTVE
K1101 SSAFLRAKEEQQDDT
Y1110 EQQDDTVYMGKVTFS
S1117 YMGKVTFSCAAGFGQ
T1131 QRHRLVLTQEQLHQL
  dynactin 1 iso3  
S2 ______MSAEASARP
S6 __MSAEASARPLRVG
S14 ARPLRVGSRVEVIGK
T87 FEDGADTTSPETPDS
S88 EDGADTTSPETPDSS
T91 ADTTSPETPDSSASK
S94 TSPETPDSSASKVLK
- gap
T121 LPTRPASTGVAGASS
S127 STGVAGASSSLGPSG
S135 SSLGPSGSASAGELS
S142 SASAGELSSSEPSTP
S166-p IPTPVLTsPGAVPPL
S175-p GAVPPLPsPsKEEEG
S177-p VPPLPsPsKEEEGLR
K193 QVRDLEEKLETLRLK
T196 DLEEKLETLRLKRAE
K253 AKEALEAKERYMEEM
T299 KERVDELTTDLEILK
K464 ARVREAQKRVEAAQE
Y476 AQETVADYQQTIKKY
S504 LTNQQEASVERQQQP
K519 PPETFDFKIKFAETK
S650 DVYKKVGSLYPEMSA
S656 GSLYPEMSAHERSLD
K685 VNVEPLTKAIKYYQH
S882 YDAERPPSKPPPVEL
S945 LLEKKLDSAAKDADE
T959 ERIEKVQTRLEETQA
T964 VQTRLEETQALLRKK
K970 ETQALLRKKEKEFEE
S1004 KQRLNSQSKRTIEGL
K1078 ILKGAQMKASLASLP
Y1107 ELPAGALYRKTSQLL
T1110 AGALYRKTSQLLETL
S1111 GALYRKTSQLLETLN
T1116 KTSQLLETLNQLSTH
K1137 TRTSPAAKSPSAQLM
S1140 SPAAKSPSAQLMEQV
K1151 MEQVAQLKSLSDTVE
K1193 SSAFLRAKEEQQDDT
Y1202 EQQDDTVYMGKVTFS
S1209 YMGKVTFSCAAGFGQ
T1223 QRHRLVLTQEQLHQL
  dynactin 1 iso6  
S19 TPSGSRMSAEASARP
S23 SRMSAEASARPLRVG
S31 ARPLRVGSRVEVIGK
T104 FEDGADTTSPETPDS
S105 EDGADTTSPETPDSS
T108 ADTTSPETPDSSASK
S111 TSPETPDSSASKVLK
T134-p KTSKLAPtARKTTTR
T151 KPTRPASTGVAGASS
S157 STGVAGASSSLGPSG
S165 SSLGPSGSASAGELS
S172 SASAGELSSSEPSTP
S196 IPTPVLTSPGAVPPL
S205 GAVPPLPSPSKEEEG
S207 VPPLPSPSKEEEGLR
K223 QVRDLEEKLETLRLK
T226 DLEEKLETLRLKRAE
K283 AKEALEAKERYMEEM
T329 KERVDELTTDLEILK
K494 ARVREAQKRVEAAQE
Y506 AQETVADYQQTIKKY
S534 LTNQQEASVERQQQP
K549 PPETFDFKIKFAETK
S680 DVYKKVGSLYPEMSA
S686 GSLYPEMSAHERSLD
K715 VNVEPLTKAIKYYQH
S912 YDAERPPSKPPPVEL
S975 LLEKKLDSAAKDADE
T989 ERIEKVQTRLEETQA
T994 VQTRLEETQALLRKK
K1000 ETQALLRKKEKEFEE
S1034 KQRLNSQSKRTIEGL
K1113 ILKGAQMKASLASLP
Y1142 ELPAGALYRKTSQLL
T1145 AGALYRKTSQLLETL
S1146 GALYRKTSQLLETLN
T1151 KTSQLLETLNQLSTH
K1172 TRTSPAAKSPSAQLM
S1175 SPAAKSPSAQLMEQV
K1186 MEQVAQLKSLSDTVE
K1228 SSAFLRAKEEQQDDT
Y1237 EQQDDTVYMGKVTFS
S1244 YMGKVTFSCAAGFGQ
T1258 QRHRLVLTQEQLHQL
  mouse

 
S19 TPSGSRMSTEASARP
S23 SRMSTEASARPLRVG
S31 ARPLRVGSRVEVIGK
T104-p FEDGADTtsPEtPDS
S105-p EDGADTtsPEtPDSS
T108-p ADTtsPEtPDSSASK
S111 tsPEtPDSSASKVLK
T141 LKPKKAPTARKTTTR
T158 KPTRPASTGVAGPSS
S164 STGVAGPSSSLGPSG
S172 SSLGPSGSASAGELS
S179 SASAGELSSSEPSTP
S203 IPTPALTSPGAAPPL
S212 GAAPPLPSPSKEEEG
S214 APPLPSPSKEEEGLR
K230 QVRDLEEKLETLRLK
T233 DLEEKLETLRLKRSE
K290 AKEALEAKERYMEEM
T336 KERVDELTTDLEILK
K501 ARVREAQKRVEAAQE
Y513 AQETVADYQQTIKKY
S541-p LTNQQEAsVERQQQP
K556-ub PPETFDFkIKFAETK
S687 DVYKKVGSLYPEMSA
S693 GSLYPEMSAHERSLD
K722-ac VNVEPLTkAIKYYQH
S919-p YDAERPPsKPPPVEL
S982 LLEKKLDSAAKDADE
T996 ERIEKVQTRLDETQT
T1001 VQTRLDETQTLLRkK
K1007-ac ETQTLLRkKEKDFEE
S1041 KQRLNSQSKRTIEGL
K1120 ILRGAQMKASLAALP
Y1152 NLVAGALYRKTsQLL
T1155 AGALYRKTsQLLEkL
S1156-p GALYRKTsQLLEkLN
K1161-ub KTsQLLEkLNQLSTH
K1182 TRSSPAAKSPSAQLM
S1185 SPAAKSPSAQLMEQV
K1196 MEQVAQLKSLSDTIE
K1238-ub SSAFLRAkEEQQDDT
Y1247 EQQDDTVYMGKVTFs
S1254-gl YMGKVTFsCAAGLGQ
T1268-p QRHRLVLtQEQLHQL
  rat

 
S19-p TPSGSRMsTEASARP
S23 SRMsTEASARPLRVG
S31 ARPLRVGSRVEVIGK
T104 FEDGADTTSPETPDS
S105 EDGADTTSPETPDSS
T108 ADTTSPETPDSSASK
S111 TSPETPDSSASKILK
T141 LKPKKAPTARKTTTR
T158 KPTRPASTGVAGPSS
S164 STGVAGPSSSLGPSG
S172 SSLGPSGSASAGELS
S179 SASAGELSSSEPSTP
S203 IPTPALTSPGAAPPL
S212 GAAPPLPSPSKEEEG
S214 APPLPSPSKEEEGLR
K230 QVRDLEEKLETLRLK
T233 DLEEKLETLRLKRSE
K289 AKEALEAKERYMEEM
T335 KERVDELTTDLEILK
K500 ARVREAQKRVEAAQE
Y512 AQETVADYQQTIKKY
S540 LTNQQEASVERQQQP
K555 PPETFDFKIKFAETK
S686 DVYKKVGSLYPEMSA
S692 GSLYPEMSAHERSLD
K721 VNVEPLTKAIKYYQH
S918 YDAERPPSKPPPVEP
S981 LLEKKLDSAAKDADE
T995 ERIEKVQTRLEETQT
T1000 VQTRLEETQTLLRKK
K1006 ETQTLLRKKEKEFEE
S1040 KQRLNSQSKRTIEGL
K1119 ILRGAQMKASLAALP
Y1151 NLLSGALYRKTSQLL
T1154 SGALYRKTSQLLEKL
S1155 GALYRKTSQLLEKLN
K1160 KTSQLLEKLNQLSTY
K1181 TRSSPACKSPSAQLM
S1184 SPACKSPSAQLMEQV
K1195 MEQVAQLKSLSDTIE
K1237 SSAFLRAKEEQQDDT
Y1246 EQQDDTVYMGKVTFS
S1253 YMGKVTFSCAAGLGQ
T1267 QRHRLVLTQEQLHQL
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