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IGF1R (pig)

Overview IGF1R a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; InsR family Reference #:  NP_999337 (RefSeq) Molecular weight: 154,956 Da Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IGF1R 1IGR - A=31-492 (human) 1JQH - A/B/C=981-1286 (human) 1K3A - A=988-1286 (human) 1M7N - A/B=974-1294 (human) 1P4O - A/B=974-1294 (human) 2OJ9 - A=982-1286 (human) 2ZM3 - A/D/C/B=981-1286 (human) 3D94 - A=986-1286 (human) 3F5P - S/F/A/J/T/K/E/B/H/M/C/D/R/I/G/L=981-1286 (human) 3I81 - A=982-1286 (human) 3LVP - A/D/C/B=951-1286 (human) 3LW0 - A/D/C/B=983-1286 (human) 3NW5 - A=982-1286 (human) 3NW6 - A=982-1286 (human) 3NW7 - A=982-1286 (human) 3O23 - A=982-1286 (human) 3QQU - A/D/C/B=988-1286 (human)

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	Sites Implicated In
activation: Y1161‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			pig
0	1		S3	_____MKSGSGGGSP
0	1		S5	___MKSGSGGGSPTS
0	1		S9	KSGSGGGSPTSLWGL
0	1		T11	GSGGGSPTSLWGLLF
0	1		S12	SGGGSPTSLWGLLFF
0	1		T28	AALSLWPTSGEICGP
0	1		S29	ALSLWPTSGEICGPG
0	1		Y113	IRGWKLFYNYALVIF
0	1		Y115	GWKLFYNYALVIFEM
0	1		T123	ALVIFEMTNLKDIGL
0	1		Y131	NLKDIGLYNLRNITR
0	1		R471	EVTGTKGRQSKGDIN
0	1		R480	SKGDINTRNNGERAS
0	1		Y577	GLKPWTQYAVYVKAV
0	1		Y580	PWTQYAVYVKAVTLT
0	1		S623	DVLSASNSSSQLIVK
0	1		S624	VLSASNSSSQLIVKW
2	1		Y973	RLGNGVLYASVNPEY
6	1		Y980	YASVNPEYFSAADVY
1	0		S982	SVNPEYFSAADVYVP
0	1		Y1014	QGSFGMVYEGVAKGV
0	1		K1023	GVAKGVVKDEPETRV
0	4		K1033	PETRVAIKTVNEAAS
1	0		K1055	LNEASVMKEFNCHHV
1	0		K1130	MAYLNANKFVHRDLA
1	0		K1150	VAEDFTVKIGDFGMT
15	464		Y1161-p	FGMTRDIyETDYYRK
0	42		T1163	MTRDIyETDYYRKGG
10	718		Y1165	RDIyETDYYRKGGKG
8	116		Y1166	DIyETDYYRKGGKGL
0	1		S1193	DGVFTTHSDVWSFGV
1	0		S1278	EPGFREVSFYYSEEN
5	0		Y1280	GFREVSFYYSEENKP
5	0		Y1281	FREVSFYYSEENKPP
2	0		S1310	VPLDPSASSSSLPLP
2	0		S1311	PLDPSASSSSLPLPD
2	0		S1312	LDPSASSSSLPLPDR
2	0		S1313	DPSASSSSLPLPDRH
1	0		S1321	LPLPDRHSGHKAENG
0	4		S1339	GVLVLRASFDERQPY
3	26		Y1346	SFDERQPYAHMNGGR
0	1		K1354	AHMNGGRKNERALPL
0	7		T1366	LPLPQSSTC______

	human
S3-p	_____MKsGsGGGsP
S5-p	___MKsGsGGGsPts
S9-p	KsGsGGGsPtsLWGL
T11-p	GsGGGsPtsLWGLLF
S12-p	sGGGsPtsLWGLLFL
T28-p	AALSLWPtsGEICGP
S29-p	ALSLWPtsGEICGPG
Y113-p	IRGWKLFyNyALVIF
Y115-p	GWKLFyNyALVIFEM
T123-p	ALVIFEMtNLKDIGL
Y131-p	NLKDIGLyNLRNITR
R471-m1	EVTGTKGrQSKGDIN
R480-m1	SKGDINTrNNGERAS
Y577-p	GLKPWTQyAVyVKAV
Y580-p	PWTQyAVyVKAVTLT
S623-p	DVLSASNssSQLIVK
S624-p	VLSASNssSQLIVKW
Y973-p	RLGNGVLyASVNPEy
Y980-p	yASVNPEyFsAADVY
S982-p	SVNPEyFsAADVYVP
Y1014-p	QGSFGMVyEGVAKGV
K1023	GVAKGVVKDEPETRV
K1033-u	PETRVAIkTVNEAAS
K1055-s	LNEASVMkEFNCHHV
K1130-s	MAYLNANkFVHRDLA
K1150-s	VAEDFTVkIGDFGMT
Y1161-p	FGMTRDIyEtDyyRK
T1163-p	MTRDIyEtDyyRKGG
Y1165-p	RDIyEtDyyRKGGKG
Y1166-p	DIyEtDyyRKGGKGL
S1193-p	DGVFTTYsDVWSFGV
S1278-p	EPGFREVsFyySEEN
Y1280-p	GFREVsFyySEENKL
Y1281-p	FREVsFyySEENKLP
S1310-p	VPLDPSAssssLPLP
S1311-p	PLDPSAssssLPLPD
S1312-p	LDPSAssssLPLPDR
S1313-p	DPSAssssLPLPDRH
S1321-p	LPLPDRHsGHKAENG
S1339-p	GVLVLRAsFDERQPy
Y1346-p	sFDERQPyAHMNGGR
K1354-m1	AHMNGGRkNERALPL
T1366-p	LPLPQSStC______

	mouse
S3	_____MKSGSGGGSP
S5	___MKSGSGGGSPTS
S9	KSGSGGGSPTSLWGL
T11	GSGGGSPTSLWGLVF
S12	SGGGSPTSLWGLVFL
T28	AALSLWPTSGEICGP
S29	ALSLWPTSGEICGPG
Y113	IRGWKLFYNYALVIF
Y115	GWKLFYNYALVIFEM
T123	ALVIFEMTNLKDIGL
Y131	NLKDIGLYNLRNITR
R472	EVTGTKGRQSKGDIN
R481	SKGDINTRNNGERAS
Y578	GLKPWTQYAVYVKAV
Y581	PWTQYAVYVKAVTLT
S624	DVLSASNSSSQLIVK
S625	VLSASNSSSQLIVKW
Y974-p	RLGNGVLyASVNPEy
Y981-p	yASVNPEyFSAADVY
S983	SVNPEyFSAADVYVP
Y1015	QGSFGMVYEGVAKGV
K1024-a	GVAKGVVkDEPETRV
K1034-u	PETRVAIkTVNEAAS
K1056	LNEASVMKEFNCHHV
K1132	MAYLNANKFVHRDLA
K1152	VAEDFTVKIGDFGMT
Y1163-p	FGMTRDIyEtDyyRK
T1165-p	MTRDIyEtDyyRKGG
Y1167-p	RDIyEtDyyRKGGKG
Y1168-p	DIyEtDyyRKGGKGL
S1195	DGVFTTHSDVWSFGV
S1280	EPSFQEVSFyySEEN
Y1282-p	SFQEVSFyySEENKP
Y1283-p	FQEVSFyySEENKPP
S1316	VPLDPSASSASLPLP
S1317	PLDPSASSASLPLPE
A1318	LDPSASSASLPLPER
S1319	DPSASSASLPLPERH
S1327	LPLPERHSGHKAENG
S1345-p	GVLVLRAsFDERQPy
Y1352-p	sFDERQPyAHMNGGR
A1360	AHMNGGRANERALPL
T1372-p	LPLPQSStC______

	rat
S3	_____MKSGSGGGSP
S5	___MKSGSGGGSPTS
S9	KSGSGGGSPTSLWGL
T11	GSGGGSPTSLWGLVF
S12	SGGGSPTSLWGLVFL
T28	AALSLWPTSGEICGP
S29	ALSLWPTSGEICGPG
Y113	IRGWKLFYNYALVIF
Y115	GWKLFYNYALVIFEM
T123	ALVIFEMTNLKDIGL
Y131	NLKDIGLYNLRNITR
R472	EVTGTKGRQSKGDIN
R481	SKGDINTRNNGERAS
Y578	GLKPWTQYAVYVKAV
Y581	PWTQYAVYVKAVTLT
S624	DVLSASNSSSQLIVK
S625	VLSASNSSSQLIVKW
Y974	RLGNGVLYASVNPEY
Y981	YASVNPEYFSAADVY
S983	SVNPEYFSAADVYVP
Y1015	QGSFGMVYEGVAKGV
K1024	GVAKGVVKDEPETRV
K1034	PETRVAIKTVNEAAS
K1056	LNEASVMKEFNCHHV
K1131	MAYLNANKFVHRDLA
K1151	VAEDFTVKIGDFGMT
Y1162-p	FGMTRDIyETDyyRK
T1164	MTRDIyETDyyRKGG
Y1166-p	RDIyETDyyRKGGKG
Y1167-p	DIyETDyyRKGGKGL
S1194	DGVFTTHSDVWSFGV
S1279	EPSFQEVSFYYSEEN
Y1281	SFQEVSFYYSEENKP
Y1282	FQEVSFYYSEENKPP
S1315	VPLDPSASSASLPLP
S1316	PLDPSASSASLPLPE
A1317	LDPSASSASLPLPER
S1318	DPSASSASLPLPERH
S1326	LPLPERHSGHKAENG
S1342	GVLVLRASFDERQPY
Y1349	SFDERQPYAHMNGGR
A1357	AHMNGGRANERALPL
T1369	LPLPQSSTC______

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