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Protein Page:
IGF1R (pig)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
IGF1R a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; TK group; InsR family
Reference #:  NP_999337 (RefSeq)
Alt. Names/Synonyms: IGF1R; insulin-like growth factor 1 receptor
Gene Symbols: IGF1R
Molecular weight: 154,956 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IGF1R

Protein Structure Not Found.


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Sites Implicated In
activity, induced: Y1161‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       pig

 
0 1 Y131 NLKDIGLYNLRNITR
0 1 Y577 GLKPWTQYAVYVKAV
0 1 Y580 PWTQYAVYVKAVTLT
2 1 Y973 RLGNGVLYASVNPEY
6 1 Y980 YASVNPEYFSAADVY
1 0 S982 SVNPEYFSAADVYVP
0 1 Y1014 QGSFGMVYEGVAKGV
0 4 K1033 PETRVAIKTVNEAAS
1 0 K1055 LNEASVMKEFNCHHV
1 0 K1130 MAYLNANKFVHRDLA
1 0 K1150 VAEDFTVKIGDFGMT
16 467 Y1161-p FGMTRDIyETDYYRK
0 43 T1163 MTRDIyETDYYRKGG
12 721 Y1165 RDIyETDYYRKGGKG
10 118 Y1166 DIyETDYYRKGGKGL
1 0 S1278 EPGFREVSFYYSEEN
5 0 Y1280 GFREVSFYYSEENKP
5 0 Y1281 FREVSFYYSEENKPP
2 0 S1310 VPLDPSASSSSLPLP
2 0 S1311 PLDPSASSSSLPLPD
2 0 S1312 LDPSASSSSLPLPDR
2 0 S1313 DPSASSSSLPLPDRH
1 0 S1321 LPLPDRHSGHKAENG
0 4 S1339 GVLVLRASFDERQPY
3 27 Y1346 SFDERQPYAHMNGGR
0 7 T1366 LPLPQSSTC______
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3918 : Phospho-IGF-1 Receptor beta (Tyr1135) (DA7A8) Rabbit mAb
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
6113 : Phospho-IGF-I Receptor beta (Tyr1316) Antibody
  human

 
Y131-p NLKDIGLyNLRNITR
Y577-p GLKPWTQyAVyVKAV
Y580-p PWTQyAVyVKAVTLT
Y973-p RLGNGVLyASVNPEy
Y980-p yASVNPEyFsAADVY
S982-p SVNPEyFsAADVYVP
Y1014-p QGSFGMVyEGVAKGV
K1033-u PETRVAIkTVNEAAS
K1055-s LNEASVMkEFNCHHV
K1130-s MAYLNANkFVHRDLA
K1150-s VAEDFTVkIGDFGMT
Y1161-p FGMTRDIyEtDyyRK
T1163-p MTRDIyEtDyyRKGG
Y1165-p RDIyEtDyyRKGGKG
Y1166-p DIyEtDyyRKGGKGL
S1278-p EPGFREVsFyySEEN
Y1280-p GFREVsFyySEENKL
Y1281-p FREVsFyySEENKLP
S1310-p VPLDPSAssssLPLP
S1311-p PLDPSAssssLPLPD
S1312-p LDPSAssssLPLPDR
S1313-p DPSAssssLPLPDRH
S1321-p LPLPDRHsGHKAENG
S1339-p GVLVLRAsFDERQPy
Y1346-p sFDERQPyAHMNGGR
T1366-p LPLPQSStC______
4568 : Phospho-IGF-I Receptor beta (Tyr980) (C14A11) Rabbit mAb
3021 : Phospho-IGF-I Receptor beta (Tyr1131)/Insulin Receptor beta (Tyr1146) Antibody
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
3918 : Phospho-IGF-1 Receptor beta (Tyr1135) (DA7A8) Rabbit mAb
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
6113 : Phospho-IGF-I Receptor beta (Tyr1316) Antibody
  mouse

 
Y131 NLKDIGLYNLRNITR
Y578 GLKPWTQYAVYVKAV
Y581 PWTQYAVYVKAVTLT
Y974-p RLGNGVLyASVNPEy
Y981-p yASVNPEyFSAADVY
S983 SVNPEyFSAADVYVP
Y1015 QGSFGMVYEGVAKGV
K1034-u PETRVAIkTVNEAAS
K1056 LNEASVMKEFNCHHV
K1132 MAYLNANKFVHRDLA
K1152 VAEDFTVKIGDFGMT
Y1163-p FGMTRDIyEtDyyRK
T1165-p MTRDIyEtDyyRKGG
Y1167-p RDIyEtDyyRKGGKG
Y1168-p DIyEtDyyRKGGKGL
S1280 EPSFQEVSFyySEEN
Y1282-p SFQEVSFyySEENKP
Y1283-p FQEVSFyySEENKPP
S1316 VPLDPSASSASLPLP
S1317 PLDPSASSASLPLPE
A1318 LDPSASSASLPLPER
S1319 DPSASSASLPLPERH
S1327 LPLPERHSGHKAENG
S1345-p GVLVLRAsFDERQPy
Y1352-p sFDERQPyAHMNGGR
T1372-p LPLPQSStC______
4568 : Phospho-IGF-I Receptor beta (Tyr980) (C14A11) Rabbit mAb
3021 : Phospho-IGF-I Receptor beta (Tyr1131)/Insulin Receptor beta (Tyr1146) Antibody
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
3918 : Phospho-IGF-1 Receptor beta (Tyr1135) (DA7A8) Rabbit mAb
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
6113 : Phospho-IGF-I Receptor beta (Tyr1316) Antibody
  rat

 
Y131 NLKDIGLYNLRNITR
Y578 GLKPWTQYAVYVKAV
Y581 PWTQYAVYVKAVTLT
Y974 RLGNGVLYASVNPEY
Y981 YASVNPEYFSAADVY
S983 SVNPEYFSAADVYVP
Y1015 QGSFGMVYEGVAKGV
K1034 PETRVAIKTVNEAAS
K1056 LNEASVMKEFNCHHV
K1131 MAYLNANKFVHRDLA
K1151 VAEDFTVKIGDFGMT
Y1162-p FGMTRDIyETDyyRK
T1164 MTRDIyETDyyRKGG
Y1166-p RDIyETDyyRKGGKG
Y1167-p DIyETDyyRKGGKGL
S1279 EPSFQEVSFYYSEEN
Y1281 SFQEVSFYYSEENKP
Y1282 FQEVSFYYSEENKPP
S1315 VPLDPSASSASLPLP
S1316 PLDPSASSASLPLPE
A1317 LDPSASSASLPLPER
S1318 DPSASSASLPLPERH
S1326 LPLPERHSGHKAENG
S1342 GVLVLRASFDERQPY
Y1349 SFDERQPYAHMNGGR
T1369 LPLPQSSTC______
4568 : Phospho-IGF-I Receptor beta (Tyr980) (C14A11) Rabbit mAb
3021 : Phospho-IGF-I Receptor beta (Tyr1131)/Insulin Receptor beta (Tyr1146) Antibody
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
3918 : Phospho-IGF-1 Receptor beta (Tyr1135) (DA7A8) Rabbit mAb
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
6113 : Phospho-IGF-I Receptor beta (Tyr1316) Antibody
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