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RhoE (human)

Overview RhoE Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Binds ROCK1. Interacts with UBXD5. Ubiquitous. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB. Protein type: G protein; Motility/polarity/chemotaxis; G protein, monomeric (Rho) Cellular Component: Golgi membrane Molecular Function: GTPase activity; GTP binding Biological Process: GTP catabolic process; small GTPase mediated signal transduction; cell adhesion; actin cytoskeleton organization and biogenesis Reference #:  P61587 (UniProtKB) Alt. Names/Synonyms: ARHE; memB; Protein MemB; ras homolog gene family, member E; Rho family GTPase 3; Rho-related GTP-binding protein Rho8; Rho-related GTP-binding protein RhoE; RHO8; RHOE; RND3; small GTP binding protein Rho8 Gene Symbols: RND3 Molecular weight: 27,368 Da Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RhoE 1M7B - A=19-200 (human) 2V55 - D/B=1-200 (human) 1GWN - A/C=14-200 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1M7B 2V55  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
intracellular localization: S11‑p protein stabilization: S11‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	1		S7-p	_MKERRAsQKLsSKS
1	0		S11-p	RRAsQKLsSKSIMDP
0	1		S218-p	QRATKRIsHMPsRPE
0	1		S222-p	KRIsHMPsRPELsAV
0	1		S227-p	MPsRPELsAVAtDLR
0	1		T231-p	PELsAVAtDLRKDKA

	mouse
S7-p	_MKERRAsQKLSSKS
S11	RRAsQKLSSKSIMDP
S218	QRATKRISHMPSRPE
S222	KRISHMPSRPELSAV
S227	MPSRPELSAVATDLR
T231	PELSAVATDLRKDKA

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