Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
BRCA2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BRCA2 involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation. Interacts with RAD51 and DSS1. Interacts with ubiquitinated FANCD2. Interacts with PALB2, enables the recombinational repair and checkpoint functions. Interacts with WDR16. Defects in BRCA2 are a cause of genetic susceptibility to breast cancer and may underlie susceptibility to uveal melanoma. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Nuclear receptor co-regulator
Cellular Component: nucleoplasm; centrosome; protein complex; cytoplasm; BRCA2-MAGE-D1 complex; nucleolus; nucleus; secretory granule
Molecular Function: gamma-tubulin binding; H4 histone acetyltransferase activity; protein binding; histone acetyltransferase activity; protease binding; H3 histone acetyltransferase activity; single-stranded DNA binding
Biological Process: positive regulation of transcription, DNA-dependent; cell aging; cytokinesis; DNA repair; positive regulation of mitotic cell cycle; oocyte maturation; inner cell mass cell proliferation; regulation of cytokinesis; response to UV-C; negative regulation of mammary gland epithelial cell proliferation; double-strand break repair via homologous recombination; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; male meiosis I; nucleotide-excision repair; double-strand break repair; response to gamma radiation; spermatogenesis; replication fork protection; hemopoiesis; brain development; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; centrosome duplication; female gonad development; response to X-ray
Reference #:  P51587 (UniProtKB)
Alt. Names/Synonyms: BRCA1/BRCA2-containing complex, subunit 2; BRCA2; BRCC2; breast and ovarian cancer susceptibility gene, early onset; breast cancer 2 tumor suppressor; breast cancer 2, early onset; breast cancer susceptibility protein BRCA2; Breast cancer type 2 susceptibility protein; BROVCA2; FACD; FAD; FAD1; FANCB; FANCD; FANCD1; Fanconi anemia group D1 protein; GLM3; PNCA2
Gene Symbols: BRCA2
Molecular weight: 384,225 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BRCA2

Protein Structure Not Found.


STRING  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB


Sites Implicated In
cell cycle regulation: S3291‑p
chromatin organization, altered: S3291‑p
cytoskeletal reorganization: S193‑p
enzymatic activity, induced: S193‑p
intracellular localization: S193‑p
molecular association, regulation: T77‑p, S193‑p, S3291‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y57-p SEHKNNNyEPNLFKT
0 11 S70-p KTPQRKPsyNQLAst
0 3 Y71-p TPQRKPsyNQLAstP
1 3 S76-p PsyNQLAstPIIFKE
2 5 T77-p syNQLAstPIIFKEQ
0 5 S93-p LTLPLYQsPVKELDK
0 6 T167-p VCGSLFHtPKFVKGR
2 2 S193-p AEVDPDMsWSSSLAT
1 1 T203-p SSLATPPtLsstVLI
1 1 S205-p LATPPtLsstVLIVR
1 1 S206-p ATPPtLsstVLIVRN
1 1 T207-p TPPtLsstVLIVRNE
0 1 F221 EEASETVFPHDTTAN
0 1 T225 ETVFPHDTTANVKSY
1 2 S239-p YFSNHDEsLKKNDRF
0 1 S253-p FIASVTDsENTNQRE
0 1 S384-p ESGSDKIsKEVVPSL
0 1 S396 PSLACEWSQLTLSGL
0 1 M408 SGLNGAQMEKIPLLH
0 2 S445-p DFLTSENsLPRISSL
0 1 K454-ac PRISSLPkSEKPLNE
0 2 S492-p KQAISGTsPVASSFQ
0 2 S497 GTsPVASSFQGIKKS
0 2 S519-p PKETFNAsFSGHMTD
0 1 S547-p LEIHTVCsQKEDSLC
0 1 S581-p LKNAGLIstLKKKTN
0 1 T582-p KNAGLIstLKKKTNK
0 1 Y592-p KKTNKFIyAIHDETS
0 1 T675-p RKCSRNEtCsNNtVI
0 1 S677-p CSRNEtCsNNtVIsQ
0 1 T680-p NEtCsNNtVIsQDLD
0 3 S683-p CsNNtVIsQDLDyKE
0 1 Y688-p VIsQDLDyKEAKCNK
0 1 S755-p YSDTDFQsQKSLLYD
0 7 S805-p LKGNNYEsDVELTKN
0 5 Y949-p SIKKDLVyVLAEENK
0 1 S973-p TLGQDLKsDIsLNID
0 1 S976-p QDLKsDIsLNIDKIP
0 1 T1104-p FNSNHNLtPSQKAEI
0 1 Y1135-p TQFRKPSyILQKSTF
0 1 E1276 VVSMFKIENHNDKtV
0 1 N1277 VSMFKIENHNDKtVS
0 1 T1282-p IENHNDKtVSEKNNK
0 1 K1286 NDKtVSEKNNKCQLI
0 1 S1331-p YTAASRNsHNLEFDG
0 1 K1474-ac HSDIRKNkMDILSyE
0 1 Y1480-p NkMDILSyEETDIVK
0 1 S1528-p LLGFHTAsGKKVkIA
0 1 K1533-ac TAsGKKVkIAkESLD
0 2 K1536-ac GKKVkIAkESLDKVK
0 1 A1572 KTLKYREACKDLELA
0 1 S1770-p LSKNKLDsGIEPVLK
0 1 S1869-p VKDIFTDsFSkVIKE
0 1 K1872-ub IFTDsFSkVIKENNE
0 1 S1926-p KVFADIQsEEILQHN
0 1 S1943-p MSGLEKVskIsPCDV
0 2 K1944-ub SGLEKVskIsPCDVs
0 1 S1946-p LEKVskIsPCDVsLE
0 1 S1951-p kIsPCDVsLETSDIC
0 2 S1970-p GKLHKSVsSANTCGI
0 1 T2031-p QLTREENtAIRtPEH
0 3 T2035-p EENtAIRtPEHLIsQ
0 1 S2041-p RtPEHLIsQKGFSYN
0 1 S2091-p DLIRTEHsLHYsPTS
0 3 S2095-p TEHsLHYsPTSRQNV
0 1 S2152-p NNHSIKVsPYLSQFQ
0 2 K2316 STPDGTIKDRRLFMH
0 2 Y2363-p FLSKSHLyEHLTLEK
0 1 K2498-ac QDMRIKKkQRQRVFP
0 1 Y2905-p LQDGAELyEAVKNAA
0 1 K2950-m2 QIQLEIRkAMESAEQ
0 1 T2967-p QGLSRDVttVWKLRI
0 2 T2968-p GLSRDVttVWKLRIV
0 1 R3005 SLLTEGKRYRIyHLA
0 1 Y3009-p EGKRYRIyHLATSKS
0 1 T3193-p ANDPKWStPTKDCtS
0 1 T3199-p StPTKDCtSGPYTAQ
0 1 T3211-p TAQIIPGtGNKLLMS
0 1 S3231-p IYYQSPLsLCMAKRK
0 1 S3239-p LCMAKRKsVStPVSA
0 4 T3242-p AKRKsVStPVSAQMT
0 1 S3250-p PVSAQMTsKSCKGEK
0 1 S3284-p LPLPPPVsPICTFVs
5 1 S3291-p sPICTFVsPAAQKAF
0 1 T3306-p QPPRSCGtKYETPIK
0 3 S3319-p IKKKELNsPQMtPFK
0 2 T3323-p ELNsPQMtPFKKFNE
0 1 S3397-p LIKEQESsQASTEEC
  mouse

 
Y57 SEYKPHGYEPQLFKT
P70 KTPQRNPPYHQFAST
Y71 TPQRNPPYHQFASTP
S76 PPYHQFASTPIMFKE
T77 PYHQFASTPIMFKER
S93 QTLPLDQSPFRELGK
T160 VSGSLFYTPKLKEGQ
S185 VEVDPDMSWTSSLAT
T195 SSLATPPTLSSTVLI
S197 LATPPTLSSTVLIAR
S198 ATPPTLSSTVLIARD
T199 TPPTLSSTVLIARDE
T213-p EEARSSVtPADsPAT
S217-p SSVtPADsPATLKSC
S231 CFSNHNESPQKNDRS
S245 SVPSVIDSENKNQQE
C376 YSQNEEICNEAVQCS
S388-p QCSDSRWsQSNLSGL
T400-p SGLNETQtGKITLPH
S435 GSITSEKSLPHISSL
E444 PHISSLPEPEKMFSE
S481 KQMVSRTSQAACLsP
S487-p TSQAACLsPSIRKSI
V508 LDETLGTVFSDSMTN
S536 LGILTACSQREDSIC
S570 VKNAGLISTLKNKKR
T571 KNAGLISTLKNKKRK
Y581 NKKRKFIYSVSDDAS
I658 GTATSKEISYIHALI
Y660 ATSKEISYIHALISQ
A663 KEISYIHALISQDLN
S666 SYIHALISQDLNDKE
D671 LISQDLNDKEAIVIE
S735 LSSISFESQENPLGD
V784 LQCESCKVNIELSKN
H930 SDSLAVVHDYTEKSR
S954 TEDKDFKSNSSLNMK
S957 KDFKSNSSLNMKSDG
T1086 DFHSNNLTTSQKAEI
H1117 TQFRKPSHIAQNTSE
K1255-ac VASVFKIkkQNTEKS
K1256-ac ASVFKIkkQNTEKSF
S1262 kkQNTEKSFDEkSSK
K1266-ac TEKSFDEkSSKCQVT
N1310 YTSSQRNNLENSDGS
K1449 LHGINKDKMHTSCHK
C1454 KDKMHTSCHKKAISI
S1502 LLSFHTASGKKVKIM
K1507 TASGKKVKIMQESLD
Q1510 GKKVKIMQESLDKVK
S1542-p GSKPLKDsKKELTLA
S1743 FLKNKIDSDVPPDMK
N1831 TKEIVTDNCYKIVEQ
K1834 IVTDNCYKIVEQNRQ
- gap
- gap
K1898 QSMSGLKKAATPPVG
T1901 SGLKKAATPPVGLET
G1905 KAATPPVGLETWDTS
H1923 REPPQAAHPSRTYGI
S1984 HSVKRENSVVHSTQG
S1988 RENSVVHSTQGVLSL
S1994 HSTQGVLSLPKPLPG
T2044 DLIRTEHTLQHsPIP
S2048-p TEHTLQHsPIPEDVS
S2105 NTQSIEVSLQLSQME
K2264-ub STPDGTVkDRSLFTH
W2311 LLSKGHPWRHSALEK
K2419 QDMRIKNKERRHLRL
Y2826 LQDGAELYAAVQYAS
K2871 RIQSEFRKALESAEK
T2887 EGLSRDVTTVWKLRV
T2888 GLSRDVTTVWKLRVT
R2924-m2 SLLTEGKrYRIYHLA
Y2928 EGKrYRIYHLAVSKS
T3111 GDSPKWSTPNKDPTR
T3117 STPNKDPTREPHAAS
S3134 CASDLLGSGGQFLRI
S3154 QSYQSPLSHCTLKGK
S3162 HCTLKGKSMPLAHSA
L3165 LKGKSMPLAHSAQMA
A3173 AHSAQMAAKSWSGEN
S3207 LPLPSPVSPICTFVS
S3214 SPICTFVSPAAQKAF
T3229 QPPRSCGTKYATPIK
P3242 IKKEPSSPRRRTPFQ
T3246 PSSPRRRTPFQKTSG
- gap
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.