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Protein Page:
PKD3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PKD3 a CAMK kinase of the PKD family. An important component of signaling pathways downstream from novel PKC enzymes after B-cell receptor engagement. Novel isoforms regulate human keratinocyte differentiation Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; CAMK group; PKD family
Cellular Component: membrane
Molecular Function: protein binding; protein kinase C activity; metal ion binding; ATP binding
Biological Process: protein kinase C activation; protein amino acid phosphorylation
Reference #:  O94806 (UniProtKB)
Alt. Names/Synonyms: EPK2; KPCD3; nPKC-nu; PKC-NU; PKD3; PRKCN; PRKD3; Protein kinase C nu type; protein kinase C, nu; protein kinase D3; Protein kinase EPK2; Serine/threonine-protein kinase D3
Gene Symbols: PRKD3
Molecular weight: 100,471 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PKD3

Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
enzymatic activity, induced: S731‑p, S735‑p
intracellular localization: S731‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S2-p ______MsANNsPPs
0 3 S6-p __MsANNsPPsAQKS
0 1 S9-p sANNsPPsAQKSVLP
0 13 S27-p PAVLPAAsPCssPKT
0 4 S30-p LPAAsPCssPKTGLs
0 8 S31-p PAAsPCssPKTGLsA
0 1 S37-p ssPKTGLsARLsNGs
0 16 S41-p TGLsARLsNGsFsAP
0 12 S44-p sARLsNGsFsAPSLT
0 2 S46-p RLsNGsFsAPSLTNS
0 1 S53 sAPSLTNSRGSVHTV
0 8 S213-p GVRKRRLsNVsLPGP
0 7 S216-p KRRLsNVsLPGPGLS
0 22 S252-p EPSKRIPsWSGRPIW
0 2 K293-u QYCKRLLkGLFRQGM
0 9 S364-p LDDTEEPsPPEDKMF
0 1 K388 ERDEEAVKtIsPSts
0 4 T389-p RDEEAVKtIsPStsN
0 15 S391-p EEAVKtIsPStsNNI
0 1 T394-p VKtIsPStsNNIPLM
0 9 S395-p KtIsPStsNNIPLMR
0 1 S415-p KHTKRKSsTMVKEGW
0 1 K443 HYWRLDSKCLTLFQN
0 12 T535-p RQALMPVtPQAsVCT
0 2 S539-p MPVtPQAsVCTsPGQ
0 4 S543-p PQAsVCTsPGQGKDH
0 2 K730-u FARIIGEksFRRsVV
2 19 S731-p ARIIGEksFRRsVVG
1 47 S735-p GEksFRRsVVGtPAy
0 1 T739-p FRRsVVGtPAyLAPE
0 5 Y742-p sVVGtPAyLAPEVLR
0 4 K816-u INNLLQVkMRKRYSV
0 1 Y852-p ETRIGERyITHESDD
0 1 Y867-p ARWEIHAyTHNLVYP
  mouse

► Hide Isoforms
 
S2 ______MSANNSPPS
S6 __MSANNSPPSAQKS
S9 SANNSPPSAQKSVFP
S27-p SAVLPAPsPCssPKT
S30-p LPAPsPCssPKTGLS
S31-p PAPsPCssPKTGLSA
S37 ssPKTGLSARLsNGs
S41-p TGLSARLsNGsFsAP
S44-p SARLsNGsFsAPSLT
S46-p RLsNGsFsAPSLTNs
S53-p sAPSLTNsRGSVHTV
S213-p GVRKRRLsNVsLPGP
S216-p KRRLsNVsLPGPGLS
S252-p EPSKRIPsWSGRPIW
K293-u QYCKRLLkGLFRQGM
S364-p LDDSEEPsPPEDKMF
K388 ERDEETVKtIsPSts
T389-p RDEETVKtIsPStsN
S391-p EETVKtIsPStsNNI
T394-p VKtIsPStsNNIPLM
S395-p KtIsPStsNNIPLMR
S415-p KHTKRRSsTVVKEGW
K443-u HYWRLDSkCLTLFQN
T535-p RQALMPVtPQAsVCT
S539-p MPVtPQAsVCTsPGQ
S543-p PQAsVCTsPGQGKDH
K729-u FARIIGEkSFRRsVV
S730 ARIIGEkSFRRsVVG
S734-p GEkSFRRsVVGtPAy
T738-p FRRsVVGtPAyLAPE
Y741-p sVVGtPAyLAPEVLR
K815 INNLLQVKMRKRYSV
Y851 ETRIGERYITHESDD
Y866 ARWEIHAYTHNLEYP
  PKD3 iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S109 GVRKRRLSNVSLPGP
S112 KRRLSNVSLPGPGLS
S148 EPSKRIPSWSGRPIW
K189 QYCKRLLKGLFRQGM
S260 LDDSEEPSPPEDKMF
K284-u ERDEETVkTIRARKF
T285 RDEETVkTIRARKFL
R287 EETVkTIRARKFLNS
K290 VkTIRARKFLNSKLK
F291 kTIRARKFLNSKLK_
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S109-p GVRKRRLsNVSLPGP
S112 KRRLsNVSLPGPGLS
S148 EPSKRIPSWSGRPIW
K189 QYCKRLLKGLFRQGL
S260-p LDDSEEPsPPEDKMF
K284 ERDEEPVKTIRARKS
T285 RDEEPVKTIRARKSL
R287 EEPVKTIRARKSLNS
K290 VKTIRARKSLNSKPK
S291 KTIRARKSLNSKPK_
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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