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PKD3 (human)

Overview PKD3 a CAMK kinase of the PKD family. An important component of signaling pathways downstream from novel PKC enzymes after B-cell receptor engagement. Novel isoforms regulate human keratinocyte differentiation Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.13; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; PKD family Cellular Component: membrane; cytoplasm; nucleolus; nucleus Molecular Function: identical protein binding; protein binding; protein kinase C activity; metal ion binding; phospholipid binding; ATP binding Biological Process: protein kinase C activation; protein amino acid phosphorylation Reference #:  O94806 (UniProtKB) Alt. Names/Synonyms: EPK2; KPCD3; nPKC-nu; PKC-NU; PKD3; PRKCN; PRKD3; Protein kinase C nu type; protein kinase C, nu; protein kinase D3; Protein kinase EPK2; protein-serine/threonine kinase; Serine/threonine-protein kinase D3 Gene Symbols: PRKD3 Molecular weight: 100,471 Da Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PKD3 2D9Z - A=414-532 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: S731‑p, S735‑p intracellular localization: S731‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S2-p	______MsANNsPPS
0	2		S6-p	__MsANNsPPSAQKS
0	12		S27-p	PAVLPAAsPCssPKT
0	4		S30-p	LPAAsPCssPKTGLs
0	8		S31-p	PAAsPCssPKTGLsA
0	1		S37-p	ssPKTGLsARLsNGs
0	13		S41-p	TGLsARLsNGsFSAP
0	9		S44-p	sARLsNGsFSAPSLT
0	2		S46	RLsNGsFSAPSLTNS
0	1		S53	SAPSLTNSRGSVHTV
0	6		S213-p	GVRKRRLsNVsLPGP
0	5		S216-p	KRRLsNVsLPGPGLS
0	20		S252-p	EPSKRIPsWsGRPIW
0	1		S254-p	SKRIPsWsGRPIWME
0	2		K293-u	QYCKRLLkGLFRQGM
0	7		S364-p	LDDTEEPsPPEDKMF
0	1		K388	ERDEEAVKtIsPSTs
0	4		T389-p	RDEEAVKtIsPSTsN
0	12		S391-p	EEAVKtIsPSTsNNI
0	6		S395-p	KtIsPSTsNNIPLMR
0	1		S415-p	KHTKRKSsTMVKEGW
0	1		K443	HYWRLDSKCLTLFQN
0	11		T535-p	RQALMPVtPQASVCT
0	1		S539	MPVtPQASVCTsPGQ
0	3		S543-p	PQASVCTsPGQGKDH
0	2		K730-u	FARIIGEksFRRsVV
2	17		S731-p	ARIIGEksFRRsVVG
1	43		S735-p	GEksFRRsVVGTPAy
0	1		T739	FRRsVVGTPAyLAPE
0	5		Y742-p	sVVGTPAyLAPEVLR
0	4		K816-u	INNLLQVkMRKRYSV
0	1		Y852-p	ETRIGERyITHESDD
0	1		Y867-p	ARWEIHAyTHNLVYP

	mouse ► Hide Isoforms
S2	______MSANNSPPS
S6	__MSANNSPPSAQKS
S27-p	SAVLPAPsPCssPKT
S30-p	LPAPsPCssPKTGLS
S31-p	PAPsPCssPKTGLSA
S37	ssPKTGLSARLsNGs
S41-p	TGLSARLsNGsFsAP
S44-p	SARLsNGsFsAPSLT
S46-p	RLsNGsFsAPSLTNs
S53-p	sAPSLTNsRGSVHTV
S213-p	GVRKRRLsNVsLPGP
S216-p	KRRLsNVsLPGPGLS
S252-p	EPSKRIPsWSGRPIW
S254	SKRIPsWSGRPIWME
K293-u	QYCKRLLkGLFRQGM
S364-p	LDDSEEPsPPEDKMF
K388	ERDEETVKtIsPSTs
T389-p	RDEETVKtIsPSTsN
S391-p	EETVKtIsPSTsNNI
S395-p	KtIsPSTsNNIPLMR
S415	KHTKRRSSTVVKEGW
K443-u	HYWRLDSkCLTLFQN
T535-p	RQALMPVtPQAsVCT
S539-p	MPVtPQAsVCTSPGQ
S543	PQAsVCTSPGQGKDH
K729-u	FARIIGEkSFRRsVV
S730	ARIIGEkSFRRsVVG
S734-p	GEkSFRRsVVGtPAy
T738-p	FRRsVVGtPAyLAPE
Y741-p	sVVGtPAyLAPEVLR
K815	INNLLQVKMRKRYSV
Y851	ETRIGERYITHESDD
Y866	ARWEIHAYTHNLEYP

	PKD3 iso3
-	gap
-	gap
-	gap
-	gap
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-	gap
-	gap
-	gap
-	gap
-	gap
S109	GVRKRRLSNVSLPGP
S112	KRRLSNVSLPGPGLS
S148	EPSKRIPSWSGRPIW
S150	SKRIPSWSGRPIWME
K189	QYCKRLLKGLFRQGM
S260	LDDSEEPSPPEDKMF
K284-u	ERDEETVkTIRARKF
T285	RDEETVkTIRARKFL
R287	EETVkTIRARKFLNS
F291	kTIRARKFLNSKLK_
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
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-	gap
-	gap

	rat
-	gap
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-	gap
S109-p	GVRKRRLsNVSLPGP
S112	KRRLsNVSLPGPGLS
S148	EPSKRIPSWSGRPIW
S150	SKRIPSWSGRPIWME
K189	QYCKRLLKGLFRQGL
S260-p	LDDSEEPsPPEDKMF
K284	ERDEEPVKTIRARKS
T285	RDEEPVKTIRARKSL
R287	EEPVKTIRARKSLNS
S291	KTIRARKSLNSKPK_
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

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