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Protein Page:
IL2RA (human)

IL2RA Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 10p15-p14
Cellular Component: plasma membrane; integral to membrane; intracellular; external side of plasma membrane
Molecular Function: interleukin-2 receptor activity; drug binding; interleukin-2 binding
Biological Process: axon guidance; nerve growth factor receptor signaling pathway; activation of MAPKK activity; apoptosis; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; cell surface receptor linked signal transduction; negative regulation of T cell proliferation; small GTPase mediated signal transduction; inflammatory response; activated T cell apoptosis; epidermal growth factor receptor signaling pathway; Notch signaling pathway; regulation of T cell homeostatic proliferation; fibroblast growth factor receptor signaling pathway; negative regulation of immune response; MAPKKK cascade; cell proliferation; inflammatory response to antigenic stimulus; positive regulation of T cell differentiation; negative regulation of inflammatory response; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; immune response; vascular endothelial growth factor receptor signaling pathway
Disease: Interleukin 2 Receptor, Alpha, Deficiency Of; Diabetes Mellitus, Insulin-dependent, 10
Reference #:  P01589 (UniProtKB)
Alt. Names/Synonyms: CD25; IDDM10; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; IL2R; IL2RA; interleukin 2 receptor, alpha; Interleukin-2 receptor subunit alpha; p55; TAC antigen; TCGFR
Gene Symbols: IL2RA
Molecular weight: 30,819 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


1 0 S268-p WQRRQRKsRRtI___
1 0 T271-p RQRKsRRtI______

T267 RWRKSRRTI______
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