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IL2RA (human)

Overview IL2RA Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane Molecular Function: interleukin-2 receptor activity; drug binding; interleukin-2 binding Biological Process: Notch signaling pathway; regulation of T cell homeostatic proliferation; apoptosis; positive regulation of apoptosis; negative regulation of immune response; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; cell proliferation; cell surface receptor linked signal transduction; negative regulation of T cell proliferation; inflammatory response to antigenic stimulus; positive regulation of T cell differentiation; negative regulation of inflammatory response; immune response; activated T cell apoptosis Reference #:  P01589 (UniProtKB) Alt. Names/Synonyms: CD25; IDDM10; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; IL2R; IL2RA; interleukin 2 receptor, alpha; Interleukin-2 receptor subunit alpha; p55; TAC antigen; TCGFR Gene Symbols: IL2RA Molecular weight: 30,819 Da Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IL2RA 1ILM - A=23-83 (human) 1ILN - A=23-83 (human) 1Z92 - B=22-238 (human) 2B5I - D=22-238 (human) 2ERJ - A/E=22-233 (human) 3IU3 - J/K/I=22-238 (human) 3NFP - K/I=22-238 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP  |  Phospho3D  |  DISEASE 147730 601942 606367  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		N78	SSHSSWDNQCQCTSS
1	0		S268-p	WQRRQRKsRRtI___
1	0		T271-p	RQRKsRRtI______

	mouse
S73-p	CLGNSWSsNCQCTSN
S264	WQHRWRKSRRTI___
T267	RWRKSRRTI______

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