Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Hydrolase; Membrane protein, multi-pass; EC 220.127.116.11; Cell adhesion; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 7q21.12
Cellular Component: cell surface; membrane; plasma membrane; integral to membrane
Molecular Function: protein binding; ATPase activity, coupled to transmembrane movement of substances; transporter activity; xenobiotic-transporting ATPase activity; ATP binding
Biological Process: response to drug; transport; xenobiotic transport; multidrug transport; G2/M transition of mitotic cell cycle; transmembrane transport
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.