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Protein Page:
ABCB1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ABCB1 Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Hydrolase; Cell adhesion; Transporter, ABC family; Membrane protein, integral; Transporter; EC 3.6.3.44
Cellular Component: cell surface; membrane; plasma membrane; integral to membrane
Molecular Function: protein binding; transporter activity; ATPase activity, coupled to transmembrane movement of substances; xenobiotic-transporting ATPase activity; ATP binding
Biological Process: response to drug; ATP catabolic process; transport; multidrug transport; xenobiotic transport; G2/M transition of mitotic cell cycle; transmembrane transport
Reference #:  P08183 (UniProtKB)
Alt. Names/Synonyms: ABC20; ABCB1; ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, subfamily B, member 1; CD243; CLCS; colchicin sensitivity; doxorubicin resistance; GP170; MDR1; MGC163296; Multidrug resistance protein 1; P-glycoprotein 1; P-GP; PGY1
Gene Symbols: ABCB1
Molecular weight: 141,479 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ABCB1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S23-p FFKLNNKsEKDKKEK
0 4 T263-p EVLAAIRtVIAFGGQ
0 1 K279-ub KELERYNkNLEEAKR
0 2 K367-ub GAAYEIFkIIDNKPS
0 1 K384-ac SYSKSGHkPDNIKGN
0 1 T496-p RYGRENVtMDEIEKA
0 2 K515-ub NAYDFIMkLPHkFDT
0 1 K519-ub FIMkLPHkFDTLVGE
0 1 S658 LEMSSNDSRSsLIRK
0 1 S660 MSSNDSRSsLIRKRs
1 7 S661-p SSNDSRSsLIRKRsT
1 14 S667-p SsLIRKRsTRRsVRG
0 5 T668 sLIRKRsTRRsVRGs
1 11 S671-p RKRsTRRsVRGsQAQ
0 1 S675-p TRRsVRGsQAQDRKL
1 1 S683-p QAQDRKLstKEALDE
0 1 T684-p AQDRKLstKEALDES
0 1 S696-p DESIPPVsFWRIMKL
0 1 K915-ub VSLTQEQkFEHMYAQ
0 1 T1015-p IIMIIEKtPLIDSYS
0 1 T1023-p PLIDSYStEGLMPNt
0 1 T1030-p tEGLMPNtLEGNVTF
0 1 Y1087-p VQLLERFyDPLAGkV
0 1 K1093-ub FyDPLAGkVLLDGKE
0 1 K1102-m1 LLDGKEIkRLNVQWL
0 1 Y1267-p LLAQKGIyFsMVSVQ
0 1 S1269-p AQKGIyFsMVSVQAG
  mouse

 
S22 FSKMGKKSKKEKKEK
T259 EVLAAIRTVIAFGGQ
N275 KELERYNNNLEEAKR
K363-ub GAAYEVFkIIDNKPS
K380 SFSKSGHKPDNIQGN
T492 RYGREDVTMDEIEKA
K511-ub NAYDFIMkLPHQFDT
Q515 FIMkLPHQFDTLVGE
S654-p LDMSSKDsGssLIRR
S656-p MSSKDsGssLIRRRs
S657-p SSKDsGssLIRRRst
S663-p ssLIRRRstRKsICG
T664-p sLIRRRstRKsICGP
S667-p RRRstRKsICGPHDQ
P671 tRKsICGPHDQDRKL
S679 HDQDRKLSTKEALDE
T680 DQDRKLSTKEALDED
S692 DEDVPPASFWRILKL
K911 VSLTREQKFETMYAQ
T1011 IIRIIEKTPEIDSYS
T1019 PEIDSYSTQGLKPNM
M1026 TQGLKPNMLEGNVQF
Y1083 VQLLERFYDPMAGSV
S1089 FYDPMAGSVFLDGKE
K1098 FLDGKEIKQLNVQWL
Y1263 LLAQKGIYFSMVSVQ
S1265 AQKGIYFSMVSVQAG
  rat

 
S22 FSKMGKKSKKEKKEK
T255 EVLAAIRTVIAFGGQ
N271 KELERYNNNLEEAKR
S359 GAAYEVFSIIDNKPS
K376 SFSKSGHKPDNIQGN
T488 RYGRENVTMDEIEKA
K507 NAYDFIMKLPHKFDT
K511 FIMKLPHKFDTLVGE
S650 VDMSSKDSGSsLIRR
S652 MSSKDSGSsLIRRRS
S653-p SSKDSGSsLIRRRST
S659 SsLIRRRSTRKSIRG
T660 sLIRRRSTRKSIRGP
S663 RRRSTRKSIRGPHDQ
P667 TRKSIRGPHDQDGEL
S675 HDQDGELSTKEALDD
T676 DQDGELSTKEALDDD
S688 DDDVPPASFWRILKL
K907 VSLTREQKFETMYAQ
I1007 IIRIIEKIPEIDSYS
T1015 PEIDSYSTEGLKPNM
M1022 TEGLKPNMLEGNVKF
Y1079 VQLLERFYDPMAGTV
T1085 FYDPMAGTVFLDGKE
K1094 FLDGKEIKQLNVQWL
Y1259 LLAQKGIYFSMVSVQ
S1261 AQKGIYFSMVSVQAG
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