Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; EC 184.108.40.206; Transporter; Hydrolase; Membrane protein, multi-pass; Transporter, ABC family; Membrane protein, integral
Cellular Component: Golgi membrane; intercellular canaliculus; cell surface; membrane; apical plasma membrane; integral to membrane; plasma membrane
Molecular Function: protein binding; transporter activity; ATPase activity, coupled to transmembrane movement of substances; xenobiotic-transporting ATPase activity; ATP binding
Biological Process: response to drug; transport; multidrug transport; G2/M transition of mitotic cell cycle; transmembrane transport
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.