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Protein Page:
CtBP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CtBP1 Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity. Homo- or heterodimer. Heterodimer with CTBP2. Interacts with PRDM16; the interaction represses white adipose tissue (WAT)- specific genes expression. Interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 and ZNF217. Interacts with adenovirus E1A protein (via its C-terminus); the interaction disrupts the interaction of CTBP1 with RBBP8. Interacts with Epstein-Barr virus EBNA3 and EBNA6. Interacts with ELK3 (via its PXDLS motif). Interacts with RBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with FOXP1, HIPK2, PNN, NRIP1, MECOM, ZNF366, ZFHX1B and WIZ. Interaction with SATB1 (non-acetylated form); the interaction stabilizes its attachment to DNA and promotes transcription repression. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor; EC 1.1.1.-
Cellular Component: transcription factor complex; transcriptional repressor complex; nucleolus; cytosol; nucleus
Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; protein homodimerization activity; NAD binding; transcription factor activity; transcription factor binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process: negative regulation of cell proliferation; positive regulation of histone deacetylation; transcription, DNA-dependent; regulation of cell cycle; white fat cell differentiation; viral genome replication; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Golgi organization and biogenesis; protein amino acid phosphorylation; negative regulation of histone acetylation
Reference #:  Q13363 (UniProtKB)
Alt. Names/Synonyms: BARS; brefeldin A-ribosylated substrate; C-terminal binding protein 1; C-terminal-binding protein 1; CTBP; CTBP1; MGC104684
Gene Symbols: CTBP1
Molecular weight: 47,535 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CtBP1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S422‑p
transcription, altered: S158‑p
transcription, induced: S158‑p
enzymatic activity, inhibited: S158‑p
intracellular localization: S158‑p
protein degradation: S158‑p, S422‑p
ubiquitination: S158‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 1 S100-p RIIVRIGsGFDNIDI
1 0 T144-p LNLYRRAtWLHQALR
4 0 S158-p REGTRVQsVEQIREV
0 2 K194-ub QAVALRAkAFGFNVL
0 4 K273-ub RGGLVDEkALAQALk
0 15 K280-ub kALAQALkEGRIRGA
0 5 S300-p ESEPFSFsQGPLKDA
3 1 S422-p AHPPHAPsPGQTVkP
2 0 K428-sm PsPGQTVkPEADRDH
  CtBP1 iso2  
S89 RIIVRIGSGFDNIDI
T133 LNLYRRATWLHQALR
S147 REGTRVQSVEQIREV
K183 QAVALRAKAFGFNVL
K262 RGGLVDEKALAQALK
K269 KALAQALKEGRIRGA
S289 ESEPFSFSQGPLKDA
S411 AHPPHAPSPGQTVKP
K417 PSPGQTVKPEADRDH
  mouse

 
S100 RIIVRIGSGFDNIDI
T144 LNLYRRTTWLHQALR
S158 REGTRVQSVEQIREV
K194 QAVALRAKAFGFNVL
K273-ub RGGLVDEkALAQALk
K280-ub kALAQALkEGRIRGA
S300 ESEPFSFSQGPLKDA
S423 AHPPHAPSPGQTVKP
K429 PSPGQTVKPEADRDH
  rat

 
S89 RIIVRIGSGFDNIDI
T133 LNLYRRTTWLHQALR
S147-p REGTRVQsVEQIREV
K183 QAVALRAKAFGFNVL
K262 RGGLVDEKALAQALK
K269 KALAQALKEGRIRGA
S289 ESEPFSFSQGPLKDA
S412 AHPPHAPSPGQTVKP
K418 PSPGQTVKPEADRDH
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