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Protein Page:
Pim2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Pim2 a Ca(2 )/calmodulin-dependent protein kinase of the PIM family. Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, CAMK; CAMK group; PIM family
Molecular Function: protein serine/threonine kinase activity; ATP binding
Biological Process: negative regulation of cell proliferation; cell proliferation; apoptotic mitochondrial changes; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein stabilization; response to virus; positive regulation of transcription, DNA-dependent; male meiosis; protein amino acid phosphorylation; positive regulation of autophagy; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Reference #:  Q9P1W9 (UniProtKB)
Alt. Names/Synonyms: pim-2 oncogene; Pim-2h; PIM2; proto-oncogene Pim-2 (serine threonine kinase); serine/threonine protein kinase pim-2; Serine/threonine-protein kinase pim-2
Gene Symbols: PIM2
Molecular weight: 34,190 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Pim2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T3-p _____MLtKPLQGPP
0 1 T15-p GPPAPPGtPTPPPGG
0 1 Y32-p REAFEAEyRLGPLLG
0 23 K40-ub RLGPLLGkGGFGTVF
0 26 K61-ub DRLQVAIkVIPRNRV
0 4 K89-ub LEVALLWkVGAGGGH
0 4 K132-ub LFDYITEkGPLGEGP
0 15 K165-ub GVVHRDIkDENILID
0 11 K179-ub DLRRGCAkLIDFGSG
0 1 T195-p LLHDEPYtDFDGTRV
0 1 S204-p FDGTRVYsPPEWISR
  mouse

 
T62 RSTSSMLTKPLQGHP
T74 GHPSPPVTPTQPPGG
Y91 RAAFEAEYRLGPLLG
K99 RLGPLLGKGGFGTVF
K120 DRRQVAIKVISRNRV
K148 LEVALLWKVGEGNGH
K191 LFDYITEKGPLGESC
K224 GVVHRDIKDENILID
K238 DLCRGSIKLIDFGSG
T254 LLHDEPYTDFDGTRV
S263 FDGTRVYSPPEWISR
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