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Pim2 (human)

Overview Pim2 a Ca(2 )/calmodulin-dependent protein kinase of the PIM family. Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Note: This description may include information from UniProtKB. Protein type: Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CAMK group; PIM family Molecular Function: protein serine/threonine kinase activity; ATP binding Biological Process: negative regulation of cell proliferation; cell proliferation; apoptotic mitochondrial changes; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein stabilization; positive regulation of transcription, DNA-dependent; response to virus; male meiosis; protein amino acid phosphorylation; positive regulation of autophagy; negative regulation of apoptosis; G1/S transition of mitotic cell cycle Reference #:  Q9P1W9 (UniProtKB) Alt. Names/Synonyms: pim-2 oncogene; Pim-2h; PIM2; proto-oncogene Pim-2 (serine threonine kinase); serine/threonine protein kinase pim-2; Serine/threonine-protein kinase pim-2 Gene Symbols: PIM2 Molecular weight: 34,190 Da Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Pim2 2IWI - A/B=1-311 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y32-p	REAFEAEyRLGPLLG
0	23		K40-u	RLGPLLGkGGFGTVF
0	26		K61-u	DRLQVAIkVIPRNRV
0	4		K89-u	LEVALLWkVGAGGGH
0	4		K132-u	LFDYITEkGPLGEGP
0	15		K165-u	GVVHRDIkDENILID
0	11		K179-u	DLRRGCAkLIDFGSG
0	1		T195-p	LLHDEPYtDFDGTRV
0	1		S204-p	FDGTRVYsPPEWISR

	mouse
Y91	RAAFEAEYRLGPLLG
K99	RLGPLLGKGGFGTVF
K120	DRRQVAIKVISRNRV
K148	LEVALLWKVGEGNGH
K191	LFDYITEKGPLGESC
K224	GVVHRDIKDENILID
K238	DLCRGSIKLIDFGSG
T254	LLHDEPYTDFDGTRV
S263	FDGTRVYSPPEWISR

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