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Protein Page:
CDK14 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDK14 a protein kinase of the CDK family. May play a role in meiosis as well as in neuron differentiation and/or function. Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.22; Motility/polarity/chemotaxis; Protein kinase, CMGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; TAIRE subfamily; CDK/TAIRE subfamily
Cellular Component: cytoplasm; plasma membrane; cytosol; nucleus
Molecular Function: protein binding; cyclin binding; cyclin-dependent protein kinase activity; ATP binding
Biological Process: Wnt receptor signaling pathway; cell division; regulation of cell cycle; G2/M transition of mitotic cell cycle; protein amino acid phosphorylation
Reference #:  O94921 (UniProtKB)
Alt. Names/Synonyms: CDK14; Cell division protein kinase 14; cyclin-dependent kinase 14; hPFTAIRE1; KIAA0834; PFTAIRE protein kinase 1; PFTAIRE1; PFTK1; Serine/threonine-protein kinase PFTAIRE-1
Gene Symbols: CDK14
Molecular weight: 53,057 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Select Structure to View Below

CDK14

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 10 S24-p KKLRRTLsESFSRIA
0 1 S26 LRRTLsESFSRIALK
0 4 T76-p KKVRVQRtQsTFDPF
0 50 S78-p VRVQRtQsTFDPFEK
0 1 T79 RVQRtQsTFDPFEKP
0 21 S95-p NQVKRVHsENNACIN
0 1 T105-p NACINFKtsSTGKES
0 1 S106-p ACINFKtsSTGKESP
0 2 S112 tsSTGKESPKVRRHs
0 9 S119-p SPKVRRHssPssPts
0 2 S120-p PKVRRHssPssPtsP
0 3 S122-p VRRHssPssPtsPKF
0 6 S123-p RRHssPssPtsPKFG
0 3 T125-p HssPssPtsPKFGKA
0 2 S126-p ssPssPtsPKFGKAD
0 12 S134-p PKFGKADsyEKLEKL
0 2 Y135-p KFGKADsyEKLEKLG
0 2 S145-p LEKLGEGsyATVYKG
0 28 Y146-p EKLGEGsyATVYKGK
0 2 K271-ub ISDTGELkLADFGLA
0 1 S420 ALSHEYFSDLPPRLW
  mouse

 
S24-p KKLRRTLsEsFSRIA
S26-p LRRTLsEsFSRIALK
T76-p KKVRVQRtQstFDPF
S78-p VRVQRtQstFDPFEK
T79-p RVQRtQstFDPFEKP
S95-p NQVKRVHsENNACIN
S105 NACINFKSSSAGKEs
S106 ACINFKSSSAGKEsP
S112-p SSSAGKEsPKVRRHs
S119-p sPKVRRHsSPssPts
S120 PKVRRHsSPssPtsP
S122-p VRRHsSPssPtsPKF
S123-p RRHsSPssPtsPKFG
T125-p HsSPssPtsPKFGKA
S126-p sSPssPtsPKFGKAD
S134-p PKFGKADsYEKLEKL
Y135 KFGKADsYEKLEKLG
S145-p LEKLGEGsyATVYKG
Y146-p EKLGEGsyATVYKGK
K271-ub ISDTGELkLADFGLA
S420-p ALSHEYFsDLPPRLW
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