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CDK14 (human)

Overview CDK14 a protein kinase of the CDK family. May play a role in meiosis as well as in neuron differentiation and/or function. Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; Kinase, protein; EC 2.7.11.22; Protein kinase, CMGC; CMGC group; CDK family; TAIRE subfamily; CDK/TAIRE subfamily Cellular Component: cytoplasm; plasma membrane; cytosol; nucleus Molecular Function: cyclin binding; protein binding; cyclin-dependent protein kinase activity; ATP binding Biological Process: Wnt receptor signaling pathway; cell division; G2/M transition of mitotic cell cycle Reference #:  O94921 (UniProtKB) Alt. Names/Synonyms: CDK14; Cell division protein kinase 14; cyclin-dependent kinase 14; hPFTAIRE1; KIAA0834; PFTAIRE protein kinase 1; PFTAIRE1; PFTK1; Serine/threonine-protein kinase PFTAIRE-1 Gene Symbols: CDK14 Molecular weight: 53,057 Da Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states

Select Structure to View Below CDK14

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	6		S24-p	KKLRRTLsESFSRIA
0	1		S26	LRRTLsESFSRIALK
0	4		T76-p	KKVRVQRtQsTFDPF
0	45		S78-p	VRVQRtQsTFDPFEK
0	1		T79	RVQRtQsTFDPFEKP
0	16		S95-p	NQVKRVHsENNACIN
0	1		T105-p	NACINFKtsSTGKES
0	1		S106-p	ACINFKtsSTGKESP
0	2		S112	tsSTGKESPKVRRHs
0	7		S119-p	SPKVRRHssPssPts
0	1		S120-p	PKVRRHssPssPtsP
0	3		S122-p	VRRHssPssPtsPKF
0	4		S123-p	RRHssPssPtsPKFG
0	2		T125-p	HssPssPtsPKFGKA
0	2		S126-p	ssPssPtsPKFGKAD
0	7		S134-p	PKFGKADsyEKLEKL
0	1		Y135-p	KFGKADsyEKLEKLG
0	2		S145-p	LEKLGEGsyATVYKG
0	33		Y146-p	EKLGEGsyATVYKGK
0	2		K271-u	ISDTGELkLADFGLA
0	1		S420	ALSHEYFSDLPPRLW

	mouse
S24-p	KKLRRTLsEsFSRIA
S26-p	LRRTLsEsFSRIALK
T76-p	KKVRVQRtQstFDPF
S78-p	VRVQRtQstFDPFEK
T79-p	RVQRtQstFDPFEKP
S95-p	NQVKRVHsENNACIN
S105	NACINFKSSSAGKEs
S106	ACINFKSSSAGKEsP
S112-p	SSSAGKEsPKVRRHs
S119-p	sPKVRRHsSPssPts
S120	PKVRRHsSPssPtsP
S122-p	VRRHsSPssPtsPKF
S123-p	RRHsSPssPtsPKFG
T125-p	HsSPssPtsPKFGKA
S126-p	sSPssPtsPKFGKAD
S134-p	PKFGKADsYEKLEKL
Y135	KFGKADsYEKLEKLG
S145-p	LEKLGEGsyATVYKG
Y146-p	EKLGEGsyATVYKGK
K271-u	ISDTGELkLADFGLA
S420-p	ALSHEYFsDLPPRLW

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