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Protein Page:
PIK3CA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIK3CA Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1- AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with IRS1 in nuclear extracts. Interacts with RUFY3. Interacts with RASD2. Interacts with APPL1. Interacts with HRAS1 and KRAS. Interaction with HRAS1/KRAS is required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2. Belongs to the PI3/PI4-kinase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; Kinase, lipid; EC 2.7.1.153; Motility/polarity/chemotaxis; EC 2.7.11.1
Cellular Component: lamellipodium; plasma membrane; phosphoinositide 3-kinase complex; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; insulin receptor substrate binding; kinase activity; protein kinase activator activity; ATP binding; phosphoinositide 3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity
Biological Process: nerve growth factor receptor signaling pathway; protein amino acid phosphorylation; T cell receptor signaling pathway; vasculature development; phosphoinositide phosphorylation; phospholipid metabolic process; protein kinase B signaling cascade; angiogenesis; negative regulation of neuron apoptosis; cardiac muscle contraction; epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; regulation of multicellular organism growth; glucose metabolic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase activity; T cell costimulation; phosphatidylinositol biosynthetic process; insulin receptor signaling pathway; innate immune response; endothelial cell migration; blood coagulation; leukocyte migration
Reference #:  P42336 (UniProtKB)
Alt. Names/Synonyms: MGC142161; MGC142163; p110-alpha; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K; PI3K-alpha; PIK3CA; PK3CA; PtdIns-3-kinase p110; PtdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha
Gene Symbols: PIK3CA
Molecular weight: 124,284 Da
Basal Isoelectric point: 6.88  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-├č Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIK3CA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 7 Y246-p LKLCVLEyQGKYILK
0 1 S275 SQYKYIRSCIMLGRM
0 2 Y294-p LMAKESLySQLPMDC
0 1 S306-p MDCFTMPsYSRRIst
0 18 S312-p PsYSRRIstAtPyMN
0 4 T313-p sYSRRIstAtPyMNG
0 1 T315-p SRRIstAtPyMNGET
0 21 Y317-p RIstAtPyMNGETST
0 1 S332-p KSLWVINsALRIKIL
0 3 Y355-p IRDIDKIyVRTGIyH
0 2 Y361-p IyVRTGIyHGGEPLC
0 1 S507-p VSREAGFsysHAGLS
0 17 Y508-p SREAGFsysHAGLSN
0 1 S509-p REAGFsysHAGLSNR
0 1 Y584-p RDEVAQMyCLVKDWP
0 1 Y698-p YCRACGMyLKHLNRQ
0 1 K720 INLTDILKQEKKDET
0 1 S874-p KGALQFNsHtLHQWL
0 1 T876-p ALQFNsHtLHQWLKD
0 1 T957-p ERVPFVLtQDFLIVI
0 1 S1003 NLFINLFSMMLGSGM
0 1 S1008 LFSMMLGSGMPELQS
0 1 Y1021 QSFDDIAYIRKTLAL
0 3 Y1038-p TEQEALEyFMKQMND
  mouse

 
Y246 LKLCVLEYQGKYILK
S275-p SQYKYIRsCIMLGRM
Y294 LMAKESLYSQLPIDS
S306 IDSFTMPSYSRRIST
S312 PSYSRRISTATPyMN
T313 SYSRRISTATPyMNG
T315 SRRISTATPyMNGET
Y317-p RISTATPyMNGETST
S332 KSLWVINSALRIKIL
Y355 IRDIDKIYVRTGIYH
Y361 IYVRTGIYHGGEPLC
S507 VSREAGFSySHTGLS
Y508-p SREAGFSySHTGLSN
S509 REAGFSySHTGLSNR
Y584 RDEVAQMYCLVKDWP
Y698 YCRACGMYLKHLNRQ
K720-ub INLTDILkQEKKDET
S874 KGALQFNSHTLHQWL
T876 ALQFNSHTLHQWLKD
T957 ERVPFVLTQDFLIVI
S1003 NLFINLFSMMLGSGM
S1008 LFSMMLGSGMPELQS
Y1021 QSFDDIAYIRKTLAL
Y1038 TEQEALEYFTKQMND
  rat

 
Y246 LKLCVLEYQGKYILK
S275 SQYKYIRSCIMLGRM
Y294 LMAKESLYSQLPIDS
S306 IDSFTMPSYSRRIST
S312 PSYSRRISTATPYMN
T313 SYSRRISTATPYMNG
T315 SRRISTATPYMNGET
Y317 RISTATPYMNGETAT
S332 KSLWVINSALRIKIL
Y355 IRDIDKIYVRTGIYH
Y361 IYVRTGIYHGGEPLC
S507 VSREAGFSYSHTGLS
Y508 SREAGFSYSHTGLSN
S509 REAGFSYSHTGLSNR
Y584 RDEVAQMYCLVKDWP
Y698 YCRACGMYLKHLNRQ
K720 INLTDILKQEKKDET
S874 KGALQFNSHTLHQWL
T876 ALQFNSHTLHQWLKD
T957 ERVPFVLTQDFLIVI
S1003-p NLFINLFsMMLGsGM
S1008-p LFsMMLGsGMPELQS
Y1021-p QSFDDIAyIRKTLAL
Y1038 TEQEALEYFTKQMND
  cow

 
Y246 LKLCVLEYQGKYILK
S275 SQYKYIRSCIMLGRM
Y294 LMAKESLYSQLPMDC
S306 MDCFTMPSYSRRIST
S312 PSYSRRISTATPYMN
T313 SYSRRISTATPYMNG
T315 SRRISTATPYMNGET
Y317 RISTATPYMNGETST
S332 KSLWVINSALRIKIL
Y355 IRDIDKIYVRTGIYH
Y361 IYVRTGIYHGGEPLC
S507 VSREAGFSYSHAGLS
Y508 SREAGFSYSHAGLSN
S509 REAGFSYSHAGLSNR
Y584 RDEVAQMYCLVKDWP
Y698 YCRACGMYLKHLNRQ
K720 INLTDILKQEKKDET
S874 KGALQFNSHTLHQWL
T876 ALQFNSHTLHQWLKD
T957 ERVPFVLTQDFLIVI
S1003 NLFINLFSMMLGSGM
S1008 LFSMMLGSGMPELQS
Y1021 QSFDDIAYIRKTLAL
Y1038 TEQEALEYFMKQMND
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