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claspin (human)

Overview claspin required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. Interacts with CHEK1 when phosphorylated. Interacts with ATR and RAD9A and these interactions are slightly reduced during checkpoint activation. Interacts with BRCA1 and this interaction increases during checkpoint activation. Note: This description may include information from UniProtKB. Protein type: Actin binding protein; Cell cycle regulation Cellular Component: nucleoplasm Molecular Function: protein binding; DNA binding Biological Process: peptidyl-serine phosphorylation; apoptosis; DNA damage checkpoint; activation of protein kinase activity; mitotic cell cycle DNA replication checkpoint; DNA replication; DNA repair; G2/M transition DNA damage checkpoint; cell cycle checkpoint; cell structure disassembly during apoptosis Reference #:  Q9HAW4 (UniProtKB) Alt. Names/Synonyms: Claspin; claspin homolog (Xenopus laevis); CLSPN; hClaspin; MGC131612; MGC131613; MGC131615 Gene Symbols: CLSPN Molecular weight: 151,094 Da Basal Isoelectric point: 4.74  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below claspin

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	Sites Implicated In
cell cycle regulation: S30‑p, S34‑p chromatin organization, altered: T916‑p molecular association, regulation: S30‑p, S34‑p, T916‑p, S945‑p protein degradation: S30‑p, S34‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S26	ISQEEADSPSDsGQG
1	0		S30-p	EADSPSDsGQGsYET
1	0		S34-p	PSDsGQGsYETIGPL
0	2		S42	YETIGPLSEGDSDEE
0	2		S46	GPLSEGDSDEEIFVS
0	1		S53	SDEEIFVSKKLKNRk
1	0		K60-u	SKKLKNRkVLQDsDs
0	7		S65-p	NRkVLQDsDsETEDT
0	7		S67-p	kVLQDsDsETEDTNA
0	3		S83-p	PEKTTYDsAEEENKE
0	1		A84	EKTTYDsAEEENKEN
0	1		N88	YDsAEEENKENLyAG
0	1		Y93-p	EENKENLyAGkNTKI
1	0		K96-u	KENLyAGkNTKIKRI
0	1		S110	IYKTVADSDESYMEK
0	1		S113	TVADSDESYMEKSLY
0	1		Y120	SYMEKSLYQENLEAQ
0	1		K187-a	MEKIRQLkkKETkNQ
0	1		K188-a	EKIRQLkkKETkNQE
0	1		K192-a	QLkkKETkNQEDDVE
0	6		S225-p	GLEDENNsPLEDEES
0	25		Y306-p	ESALNLPyHMPENKT
0	1		K319-u	KTIHDFFkRKPRPTC
0	5		L428	SPGDSSVLQQESNFL
0	1		S516	RLGADEDSFVILEPE
0	1		K544	KHANPAAKPRAGQTV
0	1		S703-p	DKENNDGssEIGKAV
0	1		S704-p	KENNDGssEIGKAVG
0	1		S714-p	GKAVGFLsVPKsLss
0	1		S718-p	GFLsVPKsLssDstL
0	6		S720-p	LsVPKsLssDstLLL
0	1		S721-p	sVPKsLssDstLLLF
0	10		S723-p	PKsLssDstLLLFKD
0	3		T724-p	KsLssDstLLLFKDS
0	1		K734-u	LFKDSSSkMGYFPTE
0	1		S744	YFPTEEKSETDENSG
0	1		K756-a	NSGKQPSkLDEDDSC
0	1		S764	LDEDDSCSLLTKESS
0	1		T802	RGTSFFPTAGGFRsP
0	9		S808-p	PTAGGFRsPsPGLFR
0	18		S810-p	AGGFRsPsPGLFRAS
0	1		S833-p	SGKLSEPsLPIEDsQ
0	6		S839-p	PsLPIEDsQDLyNAs
0	1		Y843-p	IEDsQDLyNAsPEPK
0	7		S846-p	sQDLyNAsPEPKTLF
0	11		Y887-p	VRNHRNQyQALkPRL
0	1		K891-a	RNQyQALkPRLPLAS
3	0		T916-p	DELLDLCtGKFTSQA
0	2		K925-a	KFTSQAEkHLPRKSD
2	0		S945-p	EELLNLCsGKFtsQD
0	3		T949-p	NLCsGKFtsQDAstP
0	9		S950-p	LCsGKFtsQDAstPA
0	8		S954-p	KFtsQDAstPAsSEL
0	13		T955-p	FtsQDAstPAsSELN
0	4		S958-p	QDAstPAsSELNkQE
0	1		K963-u	PAsSELNkQEKESSM
0	2		T987-p	LCSGSFPtDKEEEDE
0	1		S1012-p	SNDNEFDsDEDEHsD
0	1		S1018-p	DsDEDEHsDsGNDLA
0	1		S1020-p	DEDEHsDsGNDLALE
0	1		Y1117	DKRQLRLYQERYLAD
0	25		S1147-p	WKNIDDAsQMDLFHR
0	27		S1156-p	MDLFHRDsDDDQtEE
0	7		T1161-p	RDsDDDQtEEQLDES
0	16		S1204-p	EEEIGEDsQFMILAK
0	2		S1223-p	KALQKNAsRPMVIQE
0	12		S1289-p	NFVFHTLsPVKAEAA
0	1		V1291	VFHTLsPVKAEAAKE
0	1		S1299-p	KAEAAKEsSKSQVKK
0	1		S1310-p	QVKKRGPsFMTsPsP
0	2		S1314-p	RGPsFMTsPsPKHLK
0	3		S1316-p	PsFMTsPsPKHLKtD
0	1		T1322-p	PsPKHLKtDDSTSGL
0	1		S1325	KHLKtDDSTSGLTRS

	mouse
S26-p	LSQEAADsPVDSGQG
S30	AADsPVDSGQGSFET
S34	PVDSGQGSFETLEPL
S42-p	FETLEPLsERDsDEE
S46-p	EPLsERDsDEEIFVs
S53-p	sDEEIFVsKKPKSRK
K60	sKKPKSRKVLQDsDs
S65-p	SRKVLQDsDsEAEDR
S67-p	KVLQDsDsEAEDRDD
D83	PEKPTYDDsAEDtQE
S84-p	EKPTYDDsAEDtQEN
T88-p	YDDsAEDtQENLHSG
H93	EDtQENLHSGKSQSR
-	under review
S109-p	FPKALADsDEsDMEE
S112-p	ALADsDEsDMEETPs
S119-p	sDMEETPsQESPETQ
K182	MEKIRRLKKKETRCE
K183	EKIRRLKKKETRCEE
R187	RLKKKETRCEESDAD
S220	GLEEENDSALEDEES
Y301	ESALNLPYHMPESKT
K314	KTIHDFFKRKPRPTC
S424-p	SPGDRSMsQQESSIP
S522-p	RLGADEDsFVILDEP
S551-p	RHANPAAsPRACQTV
S682	DKENTDTSSDIGKSV
S683	KENTDTSSDIGKSVA
C692	IGKSVALCVPKPLSs
P696	VALCVPKPLSsDstL
S698	LCVPKPLSsDstLLL
S699-p	CVPKPLSsDstLLLF
S701-p	PKPLSsDstLLLFKD
T702-p	KPLSsDstLLLFKDS
K712	LFKDSSSKMGYFPTE
S722-p	YFPTEEKsETDEYLA
K734	YLAKQSDKLDEDDSS
S742-p	LDEDDSSsLLTKESS
T780-p	RGASFLPtAGFRsPs
S785-p	LPtAGFRsPsPGLFR
S787-p	tAGFRsPsPGLFRGS
S810	SGKLSEPSLPVEDsQ
S816-p	PSLPVEDsQDLYTAs
Y820	VEDsQDLYTAsPEPK
S823-p	sQDLYTAsPEPKTLF
Y864	IRNHRHRYQAVKPQL
K868	RHRYQAVKPQLPLAS
T893	DELLDLCTGQFTSQP
K903	FTSQPEEKCQPRKND
S923	EELLNLCSGKFPTQD
P927	NLCSGKFPTQDAsPV
T928	LCSGKFPTQDAsPVA
S932-p	KFPTQDAsPVAPLGL
P933	FPTQDAsPVAPLGLR
P936	QDAsPVAPLGLRSQE
R940	PVAPLGLRSQEKESS
T965	LCSGSFPTDREEEGE
S990	SKENGFASDEDEHSD
S996	ASDEDEHSDSNDEEL
S998	DEDEHSDSNDEELAL
Y1094-p	DKRRLRLyQERYLAD
S1124-p	WKHIDDTsQMDLFHR
S1133-p	MDLFHRDsDDDQVEE
V1138	RDsDDDQVEEQLDET
S1180-p	EEDIGDDsQFMMLAK
S1199	KALQKNASHTVVVQE
S1265-p	NFVFHTLsPtKAEAA
T1267-p	VFHTLsPtKAEAAKD
S1275	KAEAAKDSSKPQVRR
S1286	QVRRRGLSSMMsPsP
S1290-p	RGLSSMMsPsPKRLK
S1292-p	LSSMMsPsPKRLKTN
T1298	PsPKRLKTNGsSPGP
S1301-p	KRLKTNGsSPGPKRS

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