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Protein Page:
p15-INK4B (human)

p15-INK4B a potent inhibitor that nteracts strongly with CDK4 and CDK6. Potential effector of TGF-beta induced cell cycle arrest. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit; Inhibitor; Cell cycle regulation; Tumor suppressor
Chromosomal Location of Human Ortholog: 9p21
Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol
Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding
Biological Process: spleen development; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; megakaryocyte differentiation; mitotic cell cycle checkpoint; positive regulation of transforming growth factor beta receptor signaling pathway; cellular response to nutrient; liver development; response to organic cyclic substance; negative regulation of cell proliferation; response to cytokine stimulus; transforming growth factor beta receptor signaling pathway; cellular response to extracellular stimulus; positive regulation of epithelial cell differentiation; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; gene expression; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle; cell cycle arrest; aging; negative regulation of epithelial cell proliferation
Reference #:  P42772 (UniProtKB)
Alt. Names/Synonyms: CDK inhibitory protein; CDK4B inhibitor; CDK4I; CDKN2B; CDN2B; Cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinases 4 and 6 binding protein; INK4B; MTS-2; MTS2; Multiple tumor suppressor 2; p14-INK4b; p14_CDK inhibitor; p14_INK4B; P15; p15 CDK inhibitor; p15-INK4b; p15_INK4B; p15INK4B; TP15
Gene Symbols: CDKN2B
Molecular weight: 14,722 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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