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AEBP1
May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Secreted, signal peptide; Secreted; Transcription factor |
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Cellular Component: extracellular matrix; extracellular space; cytoplasm; nucleus
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Molecular Function: calmodulin binding; DNA binding; zinc ion binding; carboxypeptidase activity; transcription factor activity; transcription corepressor activity; metallocarboxypeptidase activity
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Biological Process: muscle development; transcription, DNA-dependent; cell adhesion; proteolysis; skeletal development
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Reference #:
Q8IUX7 (UniProtKB)
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| Alt. Names/Synonyms: ACLP; adipocyte enhancer binding protein 1; Adipocyte enhancer-binding protein 1; AE binding protein 1; AE-binding protein 1; AEBP1; Aortic carboxypeptidase-like protein; FLJ33612 |
| Gene Symbols: AEBP1 |
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Molecular weight: 130,929 Da
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Basal Isoelectric point: 5.05
Predict pI for various phosphorylation states
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