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Protein Page:
AEBP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
AEBP1 May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Transcription factor; Secreted, signal peptide
Cellular Component: extracellular matrix; extracellular space; cytoplasm; nucleus
Molecular Function: calmodulin binding; DNA binding; zinc ion binding; carboxypeptidase activity; transcription factor activity; metallocarboxypeptidase activity; transcription corepressor activity
Biological Process: muscle development; transcription, DNA-dependent; cell adhesion; proteolysis; skeletal development
Reference #:  Q8IUX7 (UniProtKB)
Alt. Names/Synonyms: ACLP; adipocyte enhancer binding protein 1; Adipocyte enhancer-binding protein 1; AE binding protein 1; AE-binding protein 1; AEBP1; Aortic carboxypeptidase-like protein; FLJ33612
Gene Symbols: AEBP1
Molecular weight: 130,929 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
Select Structure to View Below

AEBP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K98 KDKGKKGKKDKGPKV
0 2 K99 DKGKKGKKDKGPKVP
0 2 S404-p DNQIRASsMLRHGLG
0 1 K598-a GKSSRGLkIYAMEIS
1 0 T1012 IDPSRPMTPQQRRLQ
  mouse

 
K96-a KDKEKKGkkDKGPKA
K97-a DKEKKGkkDKGPKAT
S395-p DNQIRASsMLRHGLG
K589 GKSSRGLKIYAMEIS
T1003-p VDPSRPMtPQQRRMQ
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