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Protein Page:
PAK6 (human)

Overview
PAK6 a protein kinase of the STE20 family. Interacts with androgen receptor (AR), and cotranslocates into the nucleus with AR in response to androgen. Highly expressed in testis and prostate tissues. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Nuclear receptor co-regulator; EC 2.7.11.1; Protein kinase, STE; STE group; STE20 family; PAKB subfamily
Cellular Component: cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; ATP binding
Biological Process: regulation of transcription, DNA-dependent; apoptosis; cytoskeleton organization and biogenesis; protein amino acid phosphorylation
Reference #:  Q9NQU5 (UniProtKB)
Alt. Names/Synonyms: p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated kinase 6; p21-activated protein kinase 6; PAK-5; PAK-6; PAK5; PAK6; Serine/threonine-protein kinase PAK 6
Gene Symbols: PAK6
Molecular weight: 74,869 Da
Basal Isoelectric point: 9.57  Predict pI for various phosphorylation states
Select Structure to View Below

PAK6

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S165‑p, S560‑p, Y566‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T69-p VQLQPMKtVVRGSAM
0 1 S74 MKtVVRGSAMPVDGy
0 1 A75 KtVVRGSAMPVDGyI
0 1 V78 VRGSAMPVDGyIsGL
0 26 Y81-p SAMPVDGyIsGLLND
0 4 S83-p MPVDGyIsGLLNDIQ
0 1 T99-p LSVISSNtLRGRsPT
0 2 S104-p SNtLRGRsPTSRRRA
1 10 S113-p TSRRRAQsLGLLGDE
0 4 Y129-p WATDPDMyLQsPQsE
0 12 S132-p DPDMyLQsPQsERTD
0 1 S135-p MyLQsPQsERTDPHG
0 50 Y144-p RTDPHGLyLSCNGGT
1 0 S165-p MPWPEPQsPRVLPNG
0 1 S179-p GLAAKAQsLGPAEFQ
0 1 S207-p QSSPPGAsPPTGTNR
0 1 S246 GRPGGEGSPSPKTRE
1 0 S308-p SLVAKAQsLPSDQPV
1 0 T326-p SPLTTSDtssPQKSL
1 0 S327-p PLTTSDtssPQKSLR
1 0 S328-p LTTSDtssPQKSLRT
0 1 T339-p SLRTAPAtGQLPGRs
1 0 S346-p tGQLPGRssPAGSPR
1 2 S347-p GQLPGRssPAGSPRt
0 1 S351 GRssPAGSPRtWHAQ
1 0 T354-p sPAGSPRtWHAQIsT
1 0 S360-p RtWHAQIsTSNLyLP
0 14 Y365-p QIsTSNLyLPQDPtV
0 1 T371-p LyLPQDPtVAKGALA
2 37 S560-p KDVPKRKsLVGtPyW
0 6 T564-p KRKsLVGtPyWMAPE
1 0 Y566-p KsLVGtPyWMAPEVI
3241 : Phospho-PAK4 (Ser474)/PAK5 (Ser602)/PAK6 (Ser560) Antibody
  mouse

 
T69 VQLQPMKTVVRGsSV
S74-p MKTVVRGsSVPTEGY
S75 KTVVRGsSVPTEGYI
T78 VRGsSVPTEGYISGL
Y81 sSVPTEGYISGLLND
S83 VPTEGYISGLLNDIQ
T99 LSVISSNTLRGRSPT
S104 SNTLRGRSPTSRRRA
S113 TSRRRAQSLGLLGDD
Y129 WAADPDMYLQSPQSE
S132 DPDMYLQSPQSEHTD
S135 MYLQSPQSEHTDPHG
Y144 HTDPHGLYLSCNGGT
S165 VPWPEPQSPQALPNG
S179 GMAAKAQSLGPAEFQ
S208 QSSPPGTSPPMATGR
S247-p GRPGGEGsPSPKNQE
S309 NLVAKAQSLPSEQPM
T327 SPLTTSDTSSPQKSL
S328 PLTTSDTSSPQKSLR
S329 LTTSDTSSPQKSLRT
A340 SLRTAPAAGPLPGRS
S347 AGPLPGRSSPAGsPR
S348 GPLPGRSSPAGsPRT
S352-p GRSSPAGsPRTRHAQ
T355 SPAGsPRTRHAQIST
S361 RTRHAQISTSNLYLP
Y366 QISTSNLYLPQDPTV
T372 LYLPQDPTVAKGALG
S561-p KDVPKRKsLVGtPYW
T565-p KRKsLVGtPYWMAPE
Y567 KsLVGtPYWMAPEVI
  rat

 
T69 VQLQPMKTVVRGssV
S74-p MKTVVRGssVPtEGY
S75-p KTVVRGssVPtEGYI
T78-p VRGssVPtEGYIsGL
Y81 ssVPtEGYIsGLLND
S83-p VPtEGYIsGLLNDIQ
T99-p LSAISSNtLRGRSPT
S104 SNtLRGRSPTSRRRA
S113 TSRRRAQSLGLLGDD
Y129 WAADPDMYLQSPQSE
S132 DPDMYLQSPQSERTD
S135 MYLQSPQSERTDPHG
Y144 RTDPHGVYLSCNGGT
S165 TPWPEPQSPQALPNG
S179 GMAAKAQSLGPAEFQ
S207 QSSPPGTSPPMATGR
S246 GRPGGEGSPSPKTQE
S308 NLVAKAQSLPSDQPT
T326 SPLTTSDTSSPQKSL
S327 PLTTSDTSSPQKSLR
S328 LTTSDTSSPQKSLRT
T339 SLRTAPATGPLPGRS
S346 TGPLPGRSSPAGSPR
S347 GPLPGRSSPAGSPRT
S351 GRSSPAGSPRTRHAQ
T354 SPAGSPRTRHAQIST
S360 RTRHAQISTSNLYLP
Y365 QISTSNLYLPQDPTV
T371 LYLPQDPTVAKGALG
S560 KDVPKRKSLVGTPYW
T564 KRKSLVGTPYWMAPE
Y566 KSLVGTPYWMAPEVI
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