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PAK6 (human)

Overview PAK6 a protein kinase of the STE20 family. Interacts with androgen receptor (AR), and cotranslocates into the nucleus with AR in response to androgen. Highly expressed in testis and prostate tissues. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, STE; Kinase, protein; Nuclear receptor co-regulator; STE group; STE20 family; PAKB subfamily Cellular Component: cytoplasm; nucleus Molecular Function: protein serine/threonine kinase activity; ATP binding Biological Process: regulation of transcription, DNA-dependent; apoptosis; cytoskeleton organization and biogenesis Reference #:  Q9NQU5 (UniProtKB) Alt. Names/Synonyms: p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated kinase 6; p21-activated protein kinase 6; PAK-5; PAK-6; PAK5; PAK6; Serine/threonine-protein kinase PAK 6 Gene Symbols: PAK6 Molecular weight: 74,869 Da Basal Isoelectric point: 9.57  Predict pI for various phosphorylation states

Select Structure to View Below PAK6 2C30 - A=383-681 (human) 2ODB - B=11-45 (human)

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	Sites Implicated In
enzymatic activity, induced: S165‑p, S560‑p, Y566‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S74	MKTVVRGSAMPVDGy
0	1		A75	KTVVRGSAMPVDGyI
0	1		V78	VRGSAMPVDGyIsGL
0	19		Y81-p	SAMPVDGyIsGLLND
0	2		S83-p	MPVDGyIsGLLNDIQ
0	1		T99-p	LSVISSNtLRGRsPT
0	2		S104-p	SNtLRGRsPTSRRRA
0	10		S113-p	TSRRRAQsLGLLGDE
0	4		Y129-p	WATDPDMyLQsPQsE
0	12		S132-p	DPDMyLQsPQsERTD
0	1		S135-p	MyLQsPQsERTDPHG
0	41		Y144-p	RTDPHGLyLSCNGGT
1	0		S165-p	MPWPEPQsPRVLPNG
0	1		S179-p	GLAAKAQsLGPAEFQ
0	1		S207-p	QSSPPGAsPPTGTNR
0	1		S246	GRPGGEGSPSPKTRE
0	1		T339-p	SLRTAPAtGQLPGRS
0	1		S351	GRSSPAGSPRTWHAQ
0	14		Y365-p	QISTSNLyLPQDPtV
0	1		T371-p	LyLPQDPtVAKGALA
1	35		S560-p	KDVPKRKsLVGtPyW
0	4		T564-p	KRKsLVGtPyWMAPE
1	0		Y566-p	KsLVGtPyWMAPEVI

	mouse
S74-p	MKTVVRGsSVPTEGY
S75	KTVVRGsSVPTEGYI
T78	VRGsSVPTEGYISGL
Y81	sSVPTEGYISGLLND
S83	VPTEGYISGLLNDIQ
T99	LSVISSNTLRGRSPT
S104	SNTLRGRSPTSRRRA
S113	TSRRRAQSLGLLGDD
Y129	WAADPDMYLQSPQSE
S132	DPDMYLQSPQSEHTD
S135	MYLQSPQSEHTDPHG
Y144	HTDPHGLYLSCNGGT
S165	VPWPEPQSPQALPNG
S179	GMAAKAQSLGPAEFQ
S208	QSSPPGTSPPMATGR
S247-p	GRPGGEGsPSPKNQE
A340	SLRTAPAAGPLPGRS
S352-p	GRSSPAGsPRTRHAQ
Y366	QISTSNLYLPQDPTV
T372	LYLPQDPTVAKGALG
S561-p	KDVPKRKsLVGtPYW
T565-p	KRKsLVGtPYWMAPE
Y567	KsLVGtPYWMAPEVI

	rat
S74-p	MKTVVRGssVPtEGY
S75-p	KTVVRGssVPtEGYI
T78-p	VRGssVPtEGYIsGL
Y81	ssVPtEGYIsGLLND
S83-p	VPtEGYIsGLLNDIQ
T99-p	LSAISSNtLRGRSPT
S104	SNtLRGRSPTSRRRA
S113	TSRRRAQSLGLLGDD
Y129	WAADPDMYLQSPQSE
S132	DPDMYLQSPQSERTD
S135	MYLQSPQSERTDPHG
Y144	RTDPHGVYLSCNGGT
S165	TPWPEPQSPQALPNG
S179	GMAAKAQSLGPAEFQ
S207	QSSPPGTSPPMATGR
S246	GRPGGEGSPSPKTQE
T339	SLRTAPATGPLPGRS
S351	GRSSPAGSPRTRHAQ
Y365	QISTSNLYLPQDPTV
T371	LYLPQDPTVAKGALG
S560	KDVPKRKSLVGTPYW
T564	KRKSLVGTPYWMAPE
Y566	KSLVGTPYWMAPEVI

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