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Protein Page:
PAK6 (human)

Overview
PAK6 a protein kinase of the STE20 family. Interacts with androgen receptor (AR), and cotranslocates into the nucleus with AR in response to androgen. Highly expressed in testis and prostate tissues. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; STE group; STE20 family; PAKB subfamily
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; ATP binding
Biological Process: regulation of transcription, DNA-dependent; apoptosis; cytoskeleton organization and biogenesis; protein amino acid phosphorylation
Reference #:  Q9NQU5 (UniProtKB)
Alt. Names/Synonyms: p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated kinase 6; p21-activated protein kinase 6; PAK-5; PAK-6; PAK5; PAK6; Serine/threonine-protein kinase PAK 6
Gene Symbols: PAK6
Molecular weight: 74,869 Da
Basal Isoelectric point: 9.57  Predict pI for various phosphorylation states
Select Structure to View Below

PAK6

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S165‑p, S560‑p, Y566‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T69-p VQLQPMKtVVRGSAM
0 1 S74 MKtVVRGSAMPVDGy
0 1 A75 KtVVRGSAMPVDGyI
0 1 V78 VRGSAMPVDGyIsGL
0 26 Y81-p SAMPVDGyIsGLLND
0 4 S83-p MPVDGyIsGLLNDIQ
0 1 T99-p LSVISSNtLRGRsPT
0 2 S104-p SNtLRGRsPTSRRRA
1 10 S113-p TSRRRAQsLGLLGDE
0 4 Y129-p WATDPDMyLQsPQsE
0 12 S132-p DPDMyLQsPQsERTD
0 1 S135-p MyLQsPQsERTDPHG
0 50 Y144-p RTDPHGLyLSCNGGT
1 0 S165-p MPWPEPQsPRVLPNG
0 1 S179-p GLAAKAQsLGPAEFQ
0 1 S207-p QSSPPGAsPPTGTNR
0 2 S246-p GRPGGEGsPsPKTRE
0 1 S248-p PGGEGsPsPKTRESS
1 0 S308-p SLVAKAQsLPSDQPV
1 0 T326-p SPLTTSDtssPQKSL
1 0 S327-p PLTTSDtssPQKSLR
1 0 S328-p LTTSDtssPQKSLRT
0 1 T339-p SLRTAPAtGQLPGRs
1 0 S346-p tGQLPGRssPAGSPR
1 2 S347-p GQLPGRssPAGSPRt
0 1 S351 GRssPAGSPRtWHAQ
1 0 T354-p sPAGSPRtWHAQIsT
1 0 S360-p RtWHAQIsTSNLyLP
0 14 Y365-p QIsTSNLyLPQDPtV
0 1 T371-p LyLPQDPtVAKGALA
2 37 S560-p KDVPKRKsLVGtPyW
0 6 T564-p KRKsLVGtPyWMAPE
1 0 Y566-p KsLVGtPyWMAPEVI
3241 : Phospho-PAK4 (Ser474)/PAK5 (Ser602)/PAK6 (Ser560) Antibody
  mouse

 
T69 VQLQPMKTVVRGsSV
S74-p MKTVVRGsSVPTEGY
S75 KTVVRGsSVPTEGYI
T78 VRGsSVPTEGYISGL
Y81 sSVPTEGYISGLLND
S83 VPTEGYISGLLNDIQ
T99 LSVISSNTLRGRSPT
S104 SNTLRGRSPTSRRRA
S113 TSRRRAQSLGLLGDD
Y129 WAADPDMYLQSPQSE
S132 DPDMYLQSPQSEHTD
S135 MYLQSPQSEHTDPHG
Y144 HTDPHGLYLSCNGGT
S165 VPWPEPQSPQALPNG
S179 GMAAKAQSLGPAEFQ
S208 QSSPPGTSPPMATGR
S247-p GRPGGEGsPSPKNQE
S249 PGGEGsPSPKNQESS
S309 NLVAKAQSLPSEQPM
T327 SPLTTSDTSSPQKSL
S328 PLTTSDTSSPQKSLR
S329 LTTSDTSSPQKSLRT
A340 SLRTAPAAGPLPGRS
S347 AGPLPGRSSPAGsPR
S348 GPLPGRSSPAGsPRT
S352-p GRSSPAGsPRTRHAQ
T355 SPAGsPRTRHAQIST
S361 RTRHAQISTSNLYLP
Y366 QISTSNLYLPQDPTV
T372 LYLPQDPTVAKGALG
S561-p KDVPKRKsLVGtPYW
T565-p KRKsLVGtPYWMAPE
Y567 KsLVGtPYWMAPEVI
  rat

 
T69 VQLQPMKTVVRGssV
S74-p MKTVVRGssVPtEGY
S75-p KTVVRGssVPtEGYI
T78-p VRGssVPtEGYIsGL
Y81 ssVPtEGYIsGLLND
S83-p VPtEGYIsGLLNDIQ
T99-p LSAISSNtLRGRSPT
S104 SNtLRGRSPTSRRRA
S113 TSRRRAQSLGLLGDD
Y129 WAADPDMYLQSPQSE
S132 DPDMYLQSPQSERTD
S135 MYLQSPQSERTDPHG
Y144 RTDPHGVYLSCNGGT
S165 TPWPEPQSPQALPNG
S179 GMAAKAQSLGPAEFQ
S207 QSSPPGTSPPMATGR
S246 GRPGGEGSPSPKTQE
- under review  
S308 NLVAKAQSLPSDQPT
T326 SPLTTSDTSSPQKSL
S327 PLTTSDTSSPQKSLR
S328 LTTSDTSSPQKSLRT
T339 SLRTAPATGPLPGRS
S346 TGPLPGRSSPAGsPR
S347 GPLPGRSSPAGsPRT
S351-p GRSSPAGsPRTRHAQ
T354 SPAGsPRTRHAQIST
S360 RTRHAQISTSNLYLP
Y365 QISTSNLYLPQDPTV
T371 LYLPQDPTVAKGALG
S560-p KDVPKRKsLVGTPYW
T564 KRKsLVGTPYWMAPE
Y566 KsLVGTPYWMAPEVI
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