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Protein Page:
PAK5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PAK5 a protein kinase of the STE20 family. Predominantly expressed in brain. Capable of promoting neurite outgrowth, and thus may play a role in neurite development. Associated with microtubule networks and induces microtubule stabilization. Its subcellular localization is tightly regulated during cell cycle progression. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, STE; STE group; STE20 family; PAKB subfamily
Cellular Component: mitochondrion; nucleus
Molecular Function: protein serine/threonine kinase activity; ATP binding
Biological Process: cell proliferation; cell migration; apoptosis; cytoskeleton organization and biogenesis; signal transduction; cell growth; protein amino acid phosphorylation
Reference #:  Q9P286 (UniProtKB)
Alt. Names/Synonyms: KIAA1264; MGC26232; p21 protein (Cdc42/Rac)-activated kinase 7; p21(CDKN1A)-activated kinase 7; p21-activated kinase 5; p21-activated kinase 7; p21CDKN1A-activated kinase 7; PAK-5; PAK-7; PAK5; PAK7; protein kinase PAK5; Serine/threonine-protein kinase PAK 7; serine/threonine-protein kinase PAK7
Gene Symbols: PAK7
Molecular weight: 80,745 Da
Basal Isoelectric point: 8.19  Predict pI for various phosphorylation states
Select Structure to View Below

PAK5

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: S573‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 7 S104 SNSLRKESPPTPDQG
0 6 T107 LRKESPPTPDQGASS
0 1 S129 ENGFITFSQYSSESD
0 1 Y152 KYREKSLYGDDLDPY
0 1 K167-ac YRGSHAAkQNGHVMK
0 1 Y182-p MKHGEAYySEVKPLK
0 1 S226 YQRASSSSPLDYSFQ
0 2 T235 LDYSFQFTPSRTAGT
0 1 S270-p DYDRRPKssyLNQTs
0 1 S271-p YDRRPKssyLNQTsP
0 3 Y272-p DRRPKssyLNQTsPQ
0 2 S277-p ssyLNQTsPQPtMRQ
0 1 T281-p NQTsPQPtMRQrSRS
0 1 R285-m2 PQPtMRQrSRSGSGL
0 1 S286 QPtMRQrSRSGSGLQ
0 1 S315 PQGHSYNSYTYPRLS
0 1 Y316 QGHSYNSYTYPRLSE
0 3 T317 GHSYNSYTYPRLSEP
0 2 S341 DRAQMVLSPPLsGsD
0 1 S345-p MVLSPPLsGsDtyPR
0 1 S347-p LSPPLsGsDtyPRGP
0 1 T349-p PPLsGsDtyPRGPAK
0 7 Y350-p PLsGsDtyPRGPAKL
0 1 R352 sGsDtyPRGPAKLPQ
0 2 Y366 QSQSKSGYSSSSHQY
0 4 Y377 SHQYPSGYHKATLYH
1 0 S573-p HRDIKSDsILLTSDG
1 36 S602-p KEVPKRKsLVGtPYW
0 6 T606-p KRKsLVGtPYWMAPE
3241 : Phospho-PAK4 (Ser474)/PAK5 (Ser602)/PAK6 (Ser560) Antibody
  mouse

 
S104-p SNSLRKEsPPtPDQG
T107-p LRKEsPPtPDQGAAS
S129-p ENGFITFsQYSSESD
Y152 KYRDRSLYGDDLDLY
K167 YKSSHAAKQNGHAMK
Y182 MKHGDAYYPEMKSLK
S226-p YQRASSSsPLDYSFQ
T235-p LDYSFQLtPSRTAGT
S270 DYDRRPKSSYLHQTs
S271 YDRRPKSSYLHQTsP
Y272 DRRPKSSYLHQTsPQ
S277-p SSYLHQTsPQPAMRQ
A281 HQTsPQPAMRQRsKS
R285 PQPAMRQRsKSGSGL
S286-p QPAMRQRsKSGSGLQ
S315-p PQGHSYNsytYPRLS
Y316-p QGHSYNsytYPRLSE
T317-p GHSYNsytYPRLSEP
S341-p DRAQMVFsPPLSGSD
S345 MVFsPPLSGSDTyPr
S347 FsPPLSGSDTyPrGP
T349 PPLSGSDTyPrGPTK
Y350-p PLSGSDTyPrGPTKL
R352-m1 SGSDTyPrGPTKLPQ
Y366 QSQSKAGYSSGSHQY
Y377-p SHQYPSGyHKASLYH
S573 HRDIKSDSILLTSDG
S602-p KEVPKRKsLVGtPYW
T606-p KRKsLVGtPYWMAPE
  rat

 
S104 SNSLRKESPPTPDQG
T107 LRKESPPTPDQGAAS
S129 ENGFITFSQYSSESD
Y152-p KYRDRSLyGDDLDLY
K167 YRGSHAAKQNGHAMK
Y182 MKHGDAYYPEMKPLK
S226 YQRASSSSPLDYSFQ
T235 LDYSFQLTPSRTAGT
S270 DYDRRPKSSYLHQTS
S271 YDRRPKSSYLHQTSP
Y272 DRRPKSSYLHQTSPQ
S277 SSYLHQTSPQPAMRQ
A281 HQTSPQPAMRQRSKS
R285 PQPAMRQRSKSGSGL
S286 QPAMRQRSKSGSGLQ
S315 PQGHSYNSYTYPRLS
Y316 QGHSYNSYTYPRLSE
T317 GHSYNSYTYPRLSEP
S341 DRAQMVFSPPLSGSD
S345 MVFSPPLSGSDTyPR
S347 FSPPLSGSDTyPRGP
T349 PPLSGSDTyPRGPTK
Y350-p PLSGSDTyPRGPTKL
R352 SGSDTyPRGPTKLPQ
Y366-p QSQSKVGySSSSHQY
Y376-p SSHQYPGyHKASLYH
S572 HRDIKSDSILLTSDG
S601 KEVPKRKSLVGTPYW
T605 KRKSLVGTPYWMAPE
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