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PAK5 (human)

Overview PAK5 a protein kinase of the STE20 family. Predominantly expressed in brain. Capable of promoting neurite outgrowth, and thus may play a role in neurite development. Associated with microtubule networks and induces microtubule stabilization. Its subcellular localization is tightly regulated during cell cycle progression. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; PAKB subfamily Cellular Component: mitochondrion; nucleus Molecular Function: protein serine/threonine kinase activity; ATP binding Biological Process: cell proliferation; cell migration; apoptosis; cytoskeleton organization and biogenesis; signal transduction; cell growth Reference #:  Q9P286 (UniProtKB) Alt. Names/Synonyms: KIAA1264; MGC26232; p21 protein (Cdc42/Rac)-activated kinase 7; p21(CDKN1A)-activated kinase 7; p21-activated kinase 5; p21-activated kinase 7; p21CDKN1A-activated kinase 7; PAK-5; PAK-7; PAK5; PAK7; protein kinase PAK5; Serine/threonine-protein kinase PAK 7; serine/threonine-protein kinase PAK7 Gene Symbols: PAK7 Molecular weight: 80,745 Da Basal Isoelectric point: 8.19  Predict pI for various phosphorylation states

Select Structure to View Below PAK5 2F57 - A/B=425-719 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Sites Implicated In
cytoskeletal reorganization: S573‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	7		S104	SNSLRKESPPTPDQG
0	6		T107	LRKESPPTPDQGASS
0	1		S129	ENGFITFSQYSSESD
0	1		Y160-p	GDDLDPYyRGSHAAk
0	1		K167-a	yRGSHAAkQNGHVMK
0	1		Y182-p	MKHGEAYySEVKPLK
0	1		S226-p	YQRASSSsPLDYSFQ
0	2		T235-p	LDYSFQFtPSRTAGT
0	1		S270-p	DYDRRPKssyLNQTS
0	1		S271-p	YDRRPKssyLNQTSP
0	3		Y272-p	DRRPKssyLNQTSPQ
0	1		S277	ssyLNQTSPQPTMRQ
0	1		R285-m2	PQPTMRQrSRSGSGL
0	1		S286	QPTMRQrSRSGSGLQ
0	1		S315-p	PQGHSYNsYtYPRLS
0	3		Y316	QGHSYNsYtYPRLSE
0	3		T317-p	GHSYNsYtYPRLSEP
0	2		Y318	HSYNsYtYPRLSEPT
0	2		S341	DRAQMVLSPPLsGsD
0	1		S345-p	MVLSPPLsGsDtyPR
0	1		S347-p	LSPPLsGsDtyPRGP
0	1		T349-p	PPLsGsDtyPRGPAK
0	7		Y350-p	PLsGsDtyPRGPAKL
0	2		Y366	QSQSKSGYSSSSHQY
0	3		Y377	SHQYPSGYHKATLYH
1	0		S573-p	HRDIKSDsILLTSDG
1	34		S602-p	KEVPKRKsLVGtPYW
0	4		T606-p	KRKsLVGtPYWMAPE

	mouse
S104-p	SNSLRKEsPPtPDQG
T107-p	LRKEsPPtPDQGAAS
S129-p	ENGFITFsQYSSESD
Y160	GDDLDLYYKSSHAAK
K167	YKSSHAAKQNGHAMK
Y182	MKHGDAYYPEMKSLK
S226-p	YQRASSSsPLDYSFQ
T235-p	LDYSFQLtPSRTAGT
S270	DYDRRPKSSYLHQTs
S271	YDRRPKSSYLHQTsP
Y272	DRRPKSSYLHQTsPQ
S277-p	SSYLHQTsPQPAMRQ
R285	PQPAMRQRsKSGSGL
S286-p	QPAMRQRsKSGSGLQ
S315-p	PQGHSYNsytYPRLS
Y316-p	QGHSYNsytYPRLSE
T317-p	GHSYNsytYPRLSEP
Y318	HSYNsytYPRLSEPT
S341-p	DRAQMVFsPPLSGSD
S345	MVFsPPLSGSDTyPR
S347	FsPPLSGSDTyPRGP
T349	PPLSGSDTyPRGPTK
Y350-p	PLSGSDTyPRGPTKL
Y366	QSQSKAGYSSGSHQY
Y377-p	SHQYPSGyHKASLYH
S573	HRDIKSDSILLTSDG
S602-p	KEVPKRKsLVGtPYW
T606-p	KRKsLVGtPYWMAPE

	rat
S104	SNSLRKESPPTPDQG
T107	LRKESPPTPDQGAAS
S129	ENGFITFSQYSSESD
Y160-p	GDDLDLYyRGSHAAK
K167	yRGSHAAKQNGHAMK
Y182	MKHGDAYYPEMKPLK
S226	YQRASSSSPLDYSFQ
T235	LDYSFQLTPSRTAGT
S270	DYDRRPKSSYLHQTS
S271	YDRRPKSSYLHQTSP
Y272	DRRPKSSYLHQTSPQ
S277	SSYLHQTSPQPAMRQ
R285	PQPAMRQRSKSGSGL
S286	QPAMRQRSKSGSGLQ
S315	PQGHSYNSyTyPRLS
Y316-p	QGHSYNSyTyPRLSE
T317	GHSYNSyTyPRLSEP
Y318-p	HSYNSyTyPRLSEPT
S341	DRAQMVFSPPLSGSD
S345	MVFSPPLSGSDTyPR
S347	FSPPLSGSDTyPRGP
T349	PPLSGSDTyPRGPTK
Y350-p	PLSGSDTyPRGPTKL
Y366-p	QSQSKVGySSSSHQY
Y376-p	SSHQYPGyHKASLYH
S572	HRDIKSDSILLTSDG
S601	KEVPKRKSLVGTPYW
T605	KRKSLVGTPYWMAPE

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