a protein kinase of the STE20 family. Predominantly expressed in brain. Capable of promoting neurite outgrowth, and thus may play a role in neurite development. Associated with microtubule networks and induces microtubule stabilization. Its subcellular localization is tightly regulated during cell cycle progression. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; PAKB subfamily
Chromosomal Location of Human Ortholog: 20p12
Cellular Component: mitochondrion; nucleus
Molecular Function: protein serine/threonine kinase activity; ATP binding
Biological Process: cell proliferation; cell migration; apoptosis; cytoskeleton organization and biogenesis; signal transduction; cell growth; protein amino acid phosphorylation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.