Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Belongs to the G-protein coupled receptor 3 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR; Membrane protein, integral
Cellular Component: presynaptic membrane; neuron projection; cell projection; membrane; axon; integral to plasma membrane; integral to membrane; plasma membrane; synapse; intracellular; cell junction
Molecular Function: G-protein coupled receptor activity; signal transducer activity; group II metabotropic glutamate receptor activity; calcium channel regulator activity
Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; regulation of synaptic transmission, glutamatergic; glutamate secretion; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; signal transduction
Alt. Names/Synonyms: 4930441L02Rik; G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; glutamate receptor, metabotropic 2; Gprc1b; Grm2; Metabotropic glutamate receptor 2; mGluR2; mGluR7
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.