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Protein Page:
mGluR2 (mouse)

Overview
mGluR2 Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Belongs to the G-protein coupled receptor 3 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR
Cellular Component: presynaptic membrane; neuron projection; cell projection; membrane; integral to plasma membrane; axon; plasma membrane; integral to membrane; synapse; intracellular; cell junction
Molecular Function: G-protein coupled receptor activity; group II metabotropic glutamate receptor activity; signal transducer activity; calcium channel regulator activity
Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; regulation of synaptic transmission, glutamatergic; glutamate secretion; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; signal transduction
Reference #:  Q14BI2 (UniProtKB)
Alt. Names/Synonyms: 4930441L02Rik; G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; glutamate receptor, metabotropic 2; Gprc1b; Grm2; Metabotropic glutamate receptor 2; mGluR2; mGluR7
Gene Symbols: Grm2
Molecular weight: 95,887 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

mGluR2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S109 ALDFVRASLSRGADG
0 1 S111 DFVRASLSRGADGSR
0 1 S246 EKVGRAMSRAAFEGV
0 1 T457 IGRYNIFTYLRAGNG
0 1 S501 TLPASRCSEPCLQNE
1 0 S675 AQRPRFISPASQVAI
0 1 Y734 SMLGSLAYNVLLIAL
0 1 Y745 LIALCTLYAFKTRKC
0 1 T749 CTLYAFKTRKCPENF
0 1 T832-p VVSHRAPtsRFGSAA
0 1 S833-p VSHRAPtsRFGSAAP
1 0 S843 GSAAPRASANLGQGS
0 3 S871-p VVDSTTSsL______
  human

 
S109-p ALDFVRAsLsRGADG
S111-p DFVRAsLsRGADGSR
S246-p EKVGRAMsRAAFEGV
T457-p IGRYNIFtYLRAGSG
S501-p PLPASRCsEPCLQNE
S675 AQRPRFISPASQVAI
Y734-p SMLGSLAyNVLLIAL
Y745-p LIALCTLyAFKtRKC
T749-p CTLyAFKtRKCPENF
T832 VVSHRAPTSRFGSAA
S833 VSHRAPTSRFGSAAA
S843 GSAAARASSSLGQGS
S871 VVDSTTSSL______
  rat

 
S109 ALDFVRASLSRGADG
S111 DFVRASLSRGADGSR
S246 EKVGRAMSRAAFEGV
T457 IGRYNIFTYLRAGSG
S501 PLPASRCSEPCLQNE
S675-p AQRPRFIsPASQVAI
Y734 SMLGSLAYNVLLIAL
Y745 LIALCTLYAFKTRKC
T749 CTLYAFKTRKCPENF
T832 VVSHRAPTSRFGSAA
S833 VSHRAPTSRFGSAAP
S843-p GSAAPRAsANLGQGS
S871 VVDSTTSSL______
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