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mGluR2 (mouse)

Overview mGluR2 Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Belongs to the G-protein coupled receptor 3 family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; GPCR, family 3; Receptor, GPCR Cellular Component: presynaptic membrane; neuron projection; membrane; axon; plasma membrane; integral to membrane; intracellular Molecular Function: G-protein coupled receptor activity; signal transducer activity; group II metabotropic glutamate receptor activity; calcium channel regulator activity Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; glutamate secretion; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; signal transduction Reference #:  Q14BI2 (UniProtKB) Alt. Names/Synonyms: 4930441L02Rik; G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; glutamate receptor, metabotropic 2; Gprc1b; Grm2; Metabotropic glutamate receptor 2; mGluR2; mGluR7 Gene Symbols: Grm2 Molecular weight: 95,887 Da Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below mGluR2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		S109	ALDFVRASLSRGADG
0	1		S111	DFVRASLSRGADGSR
0	1		S246	EKVGRAMSRAAFEGV
0	1		T457	IGRYNIFTYLRAGNG
0	1		S501	TLPASRCSEPCLQNE
1	0		S675	AQRPRFISPASQVAI
0	1		T832-p	VVSHRAPtsRFGSAA
0	1		S833-p	VSHRAPtsRFGSAAP
1	0		S843	GSAAPRASANLGQGS
0	3		S871-p	VVDSTTSsL______

	human
S109-p	ALDFVRAsLsRGADG
S111-p	DFVRAsLsRGADGSR
S246-p	EKVGRAMsRAAFEGV
T457-p	IGRYNIFtYLRAGSG
S501-p	PLPASRCsEPCLQNE
S675	AQRPRFISPASQVAI
T832-p	VVSHRAPtsRFGSAA
S833-p	VSHRAPtsRFGSAAA
S843	GSAAARASSSLGQGS
S871	VVDSTTSSL______

	rat
S109	ALDFVRASLSRGADG
S111	DFVRASLSRGADGSR
S246	EKVGRAMSRAAFEGV
T457	IGRYNIFTYLRAGSG
S501	PLPASRCSEPCLQNE
S675-p	AQRPRFIsPASQVAI
T832	VVSHRAPTSRFGSAA
S833	VSHRAPTSRFGSAAP
S843-p	GSAAPRAsANLGQGS
S871	VVDSTTSSL______

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