|
GNB3
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2. Belongs to the WD repeat G protein beta family. Note: This description may include information from UniProtKB.
|
| Protein type: G protein; G protein, heterotrimeric beta WD; G protein, heterotrimeric |
|
Cellular Component: plasma membrane
|
|
Molecular Function: GTPase activity; GTPase binding; signal transducer activity
|
|
Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; GTP catabolic process; regulation of blood pressure; energy reserve metabolic process
|
|
Reference #:
P16520 (UniProtKB)
|
| Alt. Names/Synonyms: G protein, beta-3 subunit; GBB3; GNB3; GTP-binding regulatory protein beta-3 chain; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; hypertension associated protein; Transducin beta chain 3 |
| Gene Symbols: GNB3 |
|
Molecular weight: 37,221 Da
|
|
Basal Isoelectric point: 5.39
Predict pI for various phosphorylation states
|
|
CST Pathways:
GPCRs Signaling to MAPK/Erk
|
Parkinson's Disease
|
Phospholipase Signaling
|
PI3K/Akt Signaling
|
SAPK/JNK Signaling Cascades
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
