PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Interacts with HIV-1 Capsid protein. Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase. Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. Note: This description may include information from UniProtKB.
Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; unfolded protein binding; virion binding; peptide binding
Biological Process: release of virus from host; platelet activation; uncoating of virus; protein peptidyl-prolyl isomerization; positive regulation of viral genome replication; protein folding; viral reproduction; RNA-dependent DNA replication; virus assembly; viral infectious cycle; platelet degranulation; positive regulation of protein secretion; entry into host cell; blood coagulation; regulation of viral genome replication; leukocyte migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.