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Rab3A (human)

Overview Rab3A Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3. Specifically expressed in brain. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB. Protein type: G protein, monomeric (Rab) Cellular Component: synaptic vesicle; protein complex; plasma membrane Molecular Function: GTPase activity; protein C-terminus binding; ATPase activator activity; protein binding; GTPase binding; GTP binding; ATPase binding Biological Process: mitochondrion organization and biogenesis; synaptic vesicle maturation; neurotransmitter secretion; regulation of synaptic vesicle fusion to presynaptic membrane; post-embryonic development; respiratory system process; synaptic transmission; synaptic vesicle exocytosis; protein transport; glutamate secretion; axonogenesis; GTP catabolic process; sensory perception of touch; small GTPase mediated signal transduction; neuromuscular synaptic transmission; maintenance of presynaptic active zone structure; response to electrical stimulus; lung development Reference #:  P20336 (UniProtKB) Alt. Names/Synonyms: RAB3A; RAB3A, member RAS oncogene family; RAS-associated protein RAB3A; Ras-related protein Rab-3A Gene Symbols: RAB3A Molecular weight: 24,984 Da Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Rab3A 3RAB - A=18-186 (rat)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S7	_MASATDSRYGQKES
0	1		K12	TDSRYGQKESSDQNF
0	1		S14	SRYGQKESSDQNFDY
0	1		S15	RYGQKESSDQNFDYM
0	1		S31	KILIIGNSSVGKTSF
0	1		S32	ILIIGNSSVGKTSFL
0	1		S37	NSSVGKTSFLFRYAD
0	1		Y65-p	DFKVKTIyRNDKRIK
0	1		K72	yRNDKRIKLQIWDTA
0	1		K136	QVLLVGNKCDMEDER
0	1		K167	EFFEASAKDNINVKQ
0	3		K173	AKDNINVKQTFERLV
0	1		K186	LVDVICEKMSESLDT
0	8		S188	DVICEKMSESLDTAD
0	3		S190	ICEKMSESLDTADPA

	mouse
S7-p	_MASATDsRYGQkEs
K12-u	TDsRYGQkEssDQNF
S14-p	sRYGQkEssDQNFDY
S15-p	RYGQkEssDQNFDYM
S31-p	KILIIGNssVGKTsF
S32-p	ILIIGNssVGKTsFL
S37-p	NssVGKTsFLFRYAD
Y65	DFKVKTIYRNDKRIK
K72	YRNDKRIKLQIWDTA
K136-u	QVLLVGNkCDMEDER
K167-u	EFFEASAkDNINVkQ
K173-u	AkDNINVkQTFERLV
K186-u	LVDVICEkMsEsLDT
S188-p	DVICEkMsEsLDTAD
S190-p	ICEkMsEsLDTADPA

	rat
S7	_MASATDSRYGQKES
K12	TDSRYGQKESSDQNF
S14	SRYGQKESSDQNFDY
S15	RYGQKESSDQNFDYM
S31	KILIIGNSSVGKTSF
S32	ILIIGNSSVGKTSFL
S37	NSSVGKTSFLFRYAD
Y65	DFKVKTIYRNDKRIk
K72-u	YRNDKRIkLQIWDTA
K136	QVLLVGNKCDMEDER
K167	EFFEASAKDNINVkQ
K173-u	AKDNINVkQTFERLV
K186	LVDVICEKMSESLDT
S188	DVICEKMSESLDTAD
S190	ICEKMSESLDTADPA

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