Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3. Specifically expressed in brain. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, Rab; G protein
Cellular Component: synaptic vesicle; protein complex; plasma membrane; acrosome; cytosol
Molecular Function: protein C-terminus binding; GTPase activity; ATPase activator activity; protein binding; GTPase binding; GTP binding; ATPase binding
Biological Process: mitochondrion organization and biogenesis; synaptic vesicle maturation; regulation of synaptic vesicle fusion to presynaptic membrane; neurotransmitter secretion; post-embryonic development; synaptic transmission; respiratory system process; protein transport; synaptic vesicle exocytosis; glutamate secretion; axonogenesis; sensory perception of touch; GTP catabolic process; positive regulation of ATPase activity; small GTPase mediated signal transduction; neuromuscular synaptic transmission; maintenance of presynaptic active zone structure; response to electrical stimulus; lung development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.