Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3. Specifically expressed in brain. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric, Rab; G protein, monomeric; G protein
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: synaptic vesicle; protein complex; acrosome; plasma membrane; cytosol
Molecular Function: protein C-terminus binding; GTPase activity; ATPase activator activity; GTPase binding; protein binding; GTP binding; ATPase binding
Biological Process: mitochondrion organization and biogenesis; synaptic vesicle maturation; neurotransmitter secretion; regulation of synaptic vesicle fusion to presynaptic membrane; post-embryonic development; synaptic transmission; respiratory system process; protein transport; synaptic vesicle exocytosis; glutamate secretion; axonogenesis; positive regulation of ATPase activity; sensory perception of touch; GTP catabolic process; small GTPase mediated signal transduction; maintenance of presynaptic active zone structure; neuromuscular synaptic transmission; response to electrical stimulus; lung development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.