Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Receptor, cytokine; Cell surface; Membrane protein, integral
Cellular Component: perinuclear region of cytoplasm; cytoplasm; plasma membrane; extracellular region; integral to membrane; CD95 death-inducing signaling complex; cytosol; nucleus; lipid raft; external side of plasma membrane
Molecular Function: identical protein binding; protein binding; signal transducer activity; tumor necrosis factor receptor activity; receptor activity; kinase binding
Biological Process: response to peptide hormone stimulus; renal system process; apoptosis; positive regulation of apoptosis; response to toxin; regulation of lymphocyte differentiation; response to glucocorticoid stimulus; response to lipopolysaccharide; signal transduction; regulation of apoptosis; ovulation cycle; protein complex assembly; immunoglobulin production; activated T cell apoptosis; protein homooligomerization; aging; spleen development; response to drug; caspase activation; regulation of myeloid cell differentiation; transformed cell apoptosis; positive regulation of protein homooligomerization; negative regulation of B cell activation; negative thymic T cell selection; regulation of cell proliferation; dendrite regeneration; B cell mediated immunity; inflammatory cell apoptosis; neuron apoptosis; induction of apoptosis via death domain receptors; response to estrogen stimulus; induction of apoptosis; response to hypoxia; spermatogenesis; gene expression; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.