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Fas
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Receptor, cytokine; Cell surface; Membrane protein, integral |
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Cellular Component: perinuclear region of cytoplasm; cytoplasm; plasma membrane; extracellular region; integral to membrane; CD95 death-inducing signaling complex; cytosol; nucleus; lipid raft; external side of plasma membrane
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Molecular Function: identical protein binding; protein binding; signal transducer activity; tumor necrosis factor receptor activity; receptor activity; kinase binding
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Biological Process: response to peptide hormone stimulus; renal system process; apoptosis; positive regulation of apoptosis; response to toxin; regulation of lymphocyte differentiation; response to glucocorticoid stimulus; response to lipopolysaccharide; signal transduction; regulation of apoptosis; ovulation cycle; protein complex assembly; immunoglobulin production; activated T cell apoptosis; protein homooligomerization; aging; spleen development; response to drug; caspase activation; regulation of myeloid cell differentiation; transformed cell apoptosis; positive regulation of protein homooligomerization; negative regulation of B cell activation; negative thymic T cell selection; regulation of cell proliferation; dendrite regeneration; B cell mediated immunity; inflammatory cell apoptosis; neuron apoptosis; induction of apoptosis via death domain receptors; response to estrogen stimulus; induction of apoptosis; response to hypoxia; spermatogenesis; gene expression; negative regulation of apoptosis
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Reference #:
P25445 (UniProtKB)
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| Alt. Names/Synonyms: ALPS1A; APO-1; Apo-1 antigen; APO-1 cell surface antigen; apoptosis antigen 1; Apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; FAS; Fas (TNF receptor superfamily, member 6); Fas AMA; Fas antigen; FAS1; FASLG receptor; FASTM; TNFRSF6; TNR6; Tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6 |
| Gene Symbols: FAS |
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Molecular weight: 37,732 Da
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Basal Isoelectric point: 8.29
Predict pI for various phosphorylation states
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CST Pathways:
Death Receptor Signaling
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Mitochondrial Control of Apoptosis
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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