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NG2 (human)

Overview NG2 a transmembrane chondrotin sulfate proteoglycan expressed on several types of immature progenitor cells and human malignant melanoma cells. Plays a role in cell proliferation and motility of endothelial cells during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. May regulate MPP16-dependent degradation and invasion of type I collagen participating to melanoma cells invasion properties. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through Cdc42, ACK1 and P130Cas. May activate FAK and ERK signaling cascades. PKC-alpha-mediated NG2 phosphorylation may be a key step for initiating cell polarization and motility. Note: This description may include information from UniProtKB. Protein type: Cell adhesion; Membrane protein, integral Cellular Component: lysosomal lumen; cell surface; integral to plasma membrane; Golgi lumen; apical plasma membrane; extracellular region Molecular Function: collagen binding; signal transducer activity; protein kinase binding Biological Process: chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; activation of MAPK activity; tissue remodeling; neuron fate commitment; glial cell migration; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; chondroitin sulfate catabolic process; carbohydrate metabolic process; angiogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; neuron remodeling Reference #:  Q6UVK1 (UniProtKB) Alt. Names/Synonyms: Chondroitin sulfate proteoglycan 4; chondroitin sulfate proteoglycan 4 (melanoma-associated); Chondroitin sulfate proteoglycan NG2; CSPG4; HMW-MAA; MCSP; MCSPG; MEL-CSPG; Melanoma chondroitin sulfate proteoglycan; Melanoma-associated chondroitin sulfate proteoglycan; MSK16; NG2 Gene Symbols: CSPG4 Molecular weight: 250,537 Da Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NG2

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T21-p	LALALTLtMLARLAS
0	1		S163-p	LPYLRGTsRPLRGCL
0	1		S643-p	QDLTFRVsDGLQASP
0	1		Y743-p	VEQGRVRyLSTDPQH
0	1		T1824	TSEAFAITVRDVNER
0	1		S2036-p	LARGVNAsAVVNVtV
0	1		T2042-p	AsAVVNVtVRALLHV
0	1		T2077-p	AGELANRtGsVPRFR
0	1		S2079-p	ELANRtGsVPRFRLL
0	1		A2186	PEAARTEAGKPESST
0	1		S2203	GEPGPMASSPEPAVA
0	1		S2204	EPGPMASSPEPAVAK
2	0		T2252	YLRKRNKTGKHDVQV
1	0		T2261-p	KHDVQVLtAKPRNGL
1	1		T2310-p	ELLQFCRtPNPALKN

	mouse
A21	LALALTLALLVRSTA
S164	LPYLKGISRPLRGCL
S644	QDLTFRVSDGMQASA
Y744	VEQGRVRYLSTDPQH
T1829-p	TSEAFVItVRDVNER
S2041	LARGVNASATVNVTV
T2047	ASATVNVTVQALLHV
T2082	ASELANRTGSMPHFR
S2084	ELANRTGSMPHFRLL
T2191	PEAVRTETEKPGRSV
S2208	GQPGQAASSPVPTAA
S2209	QPGQAASSPVPTAAK
T2257	YLRKRNKTGKHDVQV
T2266	KHDVQVLTAKPRNGL
T2315	ELLQFCRTPNPALRN

	rat
A21	LALILTLALLVRSTA
S164	LPYLKGISRPLRGCL
S644	QDLTFRVSDGMQASG
Y744	VEQGRVRYLSTDPQH
T1828	TSEAFVITVRDVNER
S2040	LARGVNASATVNVTV
T2046	ASATVNVTVQALLHV
T2081	ASELANRTGSMPRFR
S2083	ELANRTGSMPRFRLL
T2190-p	PEAARTEtEKTGKST
S2207-p	GQPGQAAssPMPTVA
S2208-p	QPGQAAssPMPTVAK
T2256-p	YLRKRNKtGKHDVQV
T2265-p	KHDVQVLtAKPRNGL
T2314-p	ELLQFCRtPNPALRN

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