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Protein Page:
NG2 (human)

Overview
NG2 a transmembrane chondrotin sulfate proteoglycan expressed on several types of immature progenitor cells and human malignant melanoma cells. Plays a role in cell proliferation and motility of endothelial cells during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. May regulate MPP16-dependent degradation and invasion of type I collagen participating to melanoma cells invasion properties. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through Cdc42, ACK1 and P130Cas. May activate FAK and ERK signaling cascades. PKC-alpha-mediated NG2 phosphorylation may be a key step for initiating cell polarization and motility. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion
Cellular Component: lysosomal lumen; cell surface; integral to plasma membrane; Golgi lumen; apical plasma membrane; extracellular region
Molecular Function: signal transducer activity; protein kinase binding
Biological Process: chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; activation of MAPK activity; tissue remodeling; glial cell migration; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; chondroitin sulfate catabolic process; carbohydrate metabolic process; angiogenesis; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q6UVK1 (UniProtKB)
Alt. Names/Synonyms: Chondroitin sulfate proteoglycan 4; chondroitin sulfate proteoglycan 4 (melanoma-associated); Chondroitin sulfate proteoglycan NG2; CSPG4; HMW-MAA; MCSP; MCSPG; MEL-CSPG; Melanoma chondroitin sulfate proteoglycan; Melanoma-associated chondroitin sulfate proteoglycan; MSK16; NG2
Gene Symbols: CSPG4
Molecular weight: 250,537 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NG2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T21-p LALALTLtMLARLAS
0 1 T1824 TSEAFAITVRDVNER
0 1 A2186 PEAARTEAGKPESST
0 1 S2203 GEPGPMASSPEPAVA
0 1 S2204 EPGPMASSPEPAVAK
2 0 T2252 YLRKRNKTGKHDVQV
1 0 T2261-p KHDVQVLtAKPRNGL
1 1 T2310-p ELLQFCRtPNPALKN
0 1 Y2320-p PALKNGQyWV_____
  mouse

 
A21 LALALTLALLVRSTA
T1829-p TSEAFVItVRDVNER
T2191 PEAVRTETEKPGRSV
S2208 GQPGQAASSPVPTAA
S2209 QPGQAASSPVPTAAK
T2257 YLRKRNKTGKHDVQV
T2266 KHDVQVLTAKPRNGL
T2315 ELLQFCRTPNPALRN
Y2325 PALRNGQYWV_____
  rat

 
A21 LALILTLALLVRSTA
T1828 TSEAFVITVRDVNER
T2190-p PEAARTEtEKTGKST
S2207-p GQPGQAAssPMPTVA
S2208-p QPGQAAssPMPTVAK
T2256-p YLRKRNKtGKHDVQV
T2265-p KHDVQVLtAKPRNGL
T2314-p ELLQFCRtPNPALRN
Y2324 PALRNGQYWV_____
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