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Protein Page:
F13A1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
F13A1 Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD). FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. Belongs to the transglutaminase superfamily. Transglutaminase family. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.2.13; Transferase
Cellular Component: extracellular region
Molecular Function: protein-glutamine gamma-glutamyltransferase activity; metal ion binding
Biological Process: platelet activation; platelet degranulation; peptide cross-linking; blood coagulation
Reference #:  P00488 (UniProtKB)
Alt. Names/Synonyms: bA525O21.1 (coagulation factor XIII, A1 polypeptide); Coagulation factor XIII A chain; coagulation factor XIII A1 subunit; coagulation factor XIII, A polypeptide; coagulation factor XIII, A1 polypeptide; Coagulation factor XIIIa; F13A; F13A1; factor XIIIa; fibrin stabilizing factor, A subunit; fibrinoligase; FSF, A subunit; Protein-glutamine gamma-glutamyltransferase A chain; TGase; Transglutaminase A chain; transglutaminase. plasma
Gene Symbols: F13A1
Molecular weight: 83,267 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
Select Structure to View Below

F13A1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y84-p VRRGQSFyVQIDFSR
0 4 Y104-p RDLFRVEyVIGRyPQ
0 1 Y109-p VEyVIGRyPQENKGT
0 1 Y161-p IVGKFRMyVAVWTPY
0 1 Y241-p GILDTCLyVMDRAQM
0 2 K584-ac TLEPLSFkkEAVLIQ
0 1 K585-ac LEPLSFkkEAVLIQA
0 1 T640-p IIIKVRGtQVVGsDM
0 1 S645-p RGtQVVGsDMtVtVQ
0 1 T648-p QVVGsDMtVtVQFTN
0 1 T650-p VGsDMtVtVQFTNPL
0 1 K678-ac PGVTRPMkKMFREIR
0 1 T689-p REIRPNStVQWEEVC
  mouse

 
Y84 VRRGQTFYIQIDFNR
Y104 KDLFRVEYVIGRYPQ
Y109 VEYVIGRYPQENKGT
Y161 IVGKFRMYVAVWTPY
Y241 GILDTCLYVMDKAEM
K584 TLDPFSSKKKEVLVR
K585 LDPFSSKKKEVLVRA
A640 ITIKVRGAAMVGSDM
S645 RGAAMVGSDMVVTVE
V648 AMVGSDMVVTVEFTN
T650 VGSDMVVTVEFTNPL
R678 PGVMRPKRKVFREIR
T689 REIRPNTTVQWEEVC
  rat

 
Y84 VRRGQTFYIQIDFNR
Y104 KDLFRVEYVIGRYPQ
Y109 VEYVIGRYPQENKGT
Y161 IVGKFRMYVAVWTPY
F241 GILDACLFVMDKAEM
E584 TLDPLSLEKKEVLIR
K585 LDPLSLEKKEVLIRA
T640 VTIKVRGTAMVGSDM
S645 RGTAMVGSDMVVTVE
V648 AMVGSDMVVTVEFTN
T650 VGSDMVVTVEFTNPL
R678 PGVMRPKRKMFREIR
T689 REIRPNATVQWEEVC
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